indoramin   Click here for help

GtoPdb Ligand ID: 501

Synonyms: Baratol® | Doralese® | indoramine | WY-21901
Approved drug
indoramin is an approved drug (UK (1993))
Compound class: Synthetic organic
Comment: Indoramin is a selective antagonist of α1-adrenoceptors [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 48.13
Molecular weight 347.2
XLogP 3.8
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2
Isomeric SMILES O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2
InChI InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
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Summary of Clinical Use Click here for help
Used for the management of urinary outflow obstruction due to benign prostatic hyperplasia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Acts selectively and competitively on post-synaptic α1-adrenoceptors, causing a decrease in peripheral resistance.
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