indoramin   Click here for help

GtoPdb Ligand ID: 501

Synonyms: Baratol® | Doralese® | indoramine | WY-21901
Approved drug
indoramin is an approved drug (UK (1993))
Compound class: Synthetic organic
Comment: Indoramin is a selective antagonist of α1-adrenoceptors [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 48.13
Molecular weight 347.2
XLogP 3.8
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2
Isomeric SMILES O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2
InChI InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
1. Daniels DV, Gever JR, Jasper JR, Kava MS, Lesnick JD, Meloy TD, Stepan G, Williams TJ, Clarke DE, Chang DJ et al.. (1999)
Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies.
Eur J Pharmacol, 370 (3): 337-43. [PMID:10334511]
2. Ford AP, Daniels DV, Chang DJ, Gever JR, Jasper JR, Lesnick JD, Clarke DE. (1997)
Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification.
Br J Pharmacol, 121 (6): 1127-35. [PMID:9249248]
3. Pierce V, Shepperson NB, Todd MH, Waterfall JF. (1986)
Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin.
Br J Pharmacol, 87 (2): 433-41. [PMID:3955309]