tranilast   Click here for help

GtoPdb Ligand ID: 6326

Synonyms: MK-341 | SB-252218
Approved drug PDB Ligand Immunopharmacology Ligand
tranilast is an approved drug
Compound class: Synthetic organic
Comment: Tranilast is an anti-allergic drug, with a complex mechanism of action [1,4], and potential antiproliferative activity [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 84.86
Molecular weight 327.11
XLogP 2.87
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc(C=CC(=O)Nc2ccccc2C(=O)O)ccc1OC
Isomeric SMILES COc1cc(/C=C/C(=O)Nc2ccccc2C(=O)O)ccc1OC
InChI InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
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Summary of Clinical Use Click here for help
Approved to treat bronchial asthma and keloid and hypertrophic scars. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Tranilast is a histamine H1-receptor antagonist.