Synonyms: MK-341 | SB-252218
tranilast is an approved drug
Compound class:
Synthetic organic
Comment: Tranilast is an anti-allergic drug, with a complex mechanism of action [1,4], and potential antiproliferative activity [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Baba A, Tachi M, Ejima Y, Endo Y, Toyama H, Matsubara M, Saito K, Yamauchi M, Miura C, Kazama I. (2016)
Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties. Cell Physiol Biochem, 38 (1): 15-27. [PMID:26741745] |
2. Nakajima Y, Itoh T, Morino Y. (2016)
Metal allergy to everolimus-eluting cobalt chromium stents confirmed by positive skin testing as a cause of recurrent multivessel in-stent restenosis. Catheter Cardiovasc Interv, 87 (4): 137-142. [PMID:26011018] |
3. Nie L, Oishi Y, Doi I, Shibata H, Kojima I. (1997)
Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca(2+)-permeable channel. Cell Calcium, 22 (2): 75-82. [PMID:9292225] |
4. Zampini P, Riviera AP, Tridente G. (1983)
In vitro inhibition of histamine release from mouse mast cells and human basophils by an anthranilic acid derivative. Int J Immunopharmacol, 5 (5): 431-5. [PMID:6197383] |