AZD0328   Click here for help

GtoPdb Ligand ID: 7697

Synonyms: AZD 0328 | AZD-0328
Compound class: Synthetic organic
Comment: AZD0328 is a nicotinic acetylcholine receptor alpha 7 (α7 nAChR) agonist. AZD0328 was developed as a potential treatment for the cognitive impairment associated with diseases such as schizophrenia and Alzheimer's disease. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 25.36
Molecular weight 216.13
XLogP 1.67
No. Lipinski's rules broken 0
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Canonical SMILES c1cnc2c(c1)CC1(O2)CN2CCC1CC2
Isomeric SMILES c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2
InChI InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1
No information available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
AZD0328 modulation of α7 nAChRs enhances cortical dopamine levels and this may be causative in the positive behavioral responses reported in animal models treated with this compound [2].