- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: AZD 0328 | AZD-0328
Compound class: Synthetic organic
Comment: AZD0328 is a nicotinic acetylcholine receptor alpha 7 (α7 nAChR) agonist. AZD0328 was developed as a potential treatment for the cognitive impairment associated with diseases such as schizophrenia and Alzheimer's disease. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Mazurov AA, Speake JD, Yohannes D. (2011)
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
J Med Chem, 54 (23): 7943-61. [PMID:21919481]
2. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP et al.. (2009)
Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.
Biochem Pharmacol, 78 (7): 880-8. [PMID:19615981]