AZD0328   Click here for help

GtoPdb Ligand ID: 7697

Synonyms: AZD 0328 | AZD-0328
Compound class: Synthetic organic
Comment: AZD0328 is a nicotinic acetylcholine receptor alpha 7 (α7 nAChR) agonist. AZD0328 was developed as a potential treatment for the cognitive impairment associated with diseases such as schizophrenia and Alzheimer's disease. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 25.36
Molecular weight 216.13
XLogP 1.67
No. Lipinski's rules broken 0
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Canonical SMILES c1cnc2c(c1)CC1(O2)CN2CCC1CC2
Isomeric SMILES c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2
InChI InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1
1. Mazurov AA, Speake JD, Yohannes D. (2011)
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
J Med Chem, 54 (23): 7943-61. [PMID:21919481]
2. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP et al.. (2009)
Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.
Biochem Pharmacol, 78 (7): 880-8. [PMID:19615981]