AZD0328   Click here for help

GtoPdb Ligand ID: 7697

Synonyms: AZD 0328 | AZD-0328
Compound class: Synthetic organic
Comment: AZD0328 is a nicotinic acetylcholine receptor alpha 7 (α7 nAChR) agonist. AZD0328 was developed as a potential treatment for the cognitive impairment associated with diseases such as schizophrenia and Alzheimer's disease. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 25.36
Molecular weight 216.13
XLogP 1.67
No. Lipinski's rules broken 0
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Canonical SMILES c1cnc2c(c1)CC1(O2)CN2CCC1CC2
Isomeric SMILES c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2
InChI InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1
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Molecular structure representations generated using Open Babel