pyridostigmine   Click here for help

GtoPdb Ligand ID: 8994

Synonyms: Mestinon® | Regonol®
Approved drug
pyridostigmine is an approved drug (FDA (1955))
Compound class: Synthetic organic
Comment: Pyridostigmine is a peripherally acting, orally active reversible acetylcholinesterase (ACHE) inhibitor, with a slightly longer duration of action than neostigmine. Marketed formulations contain pyridostigmine bromide (PubChem CID 7550).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 33.42
Molecular weight 181.1
XLogP 1.98
No. Lipinski's rules broken 0
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Canonical SMILES C[n+]1cccc(c1)OC(=O)N(C)C
Isomeric SMILES C[n+]1cccc(c1)OC(=O)N(C)C
InChI InChI=1S/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1
No information available.
Summary of Clinical Use Click here for help
Used to treat muscle weakness in people with myasthenia gravis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibits acetylcholinesterase, thereby increasing the level and duration of action of the neurotransmitter acetylcholine.
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