Ligand id: 5535

Name: chloroquine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 28.16
Molecular weight 319.18
XLogP 4.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
Chloroquine was first described in 1934, emerging from a search for synthetic antimalarial compounds that were superior to quinine. From the mid-1940s, chloroquine use became widespread as both a highly effective treatment for all forms of malaria and as a prophylactic agent. The emergence of strains of P. falciparum resistant to the drug was first reported in 1957 and has continued to spread. Chloroquine is still a useful medicine for prevention and treatment in malaria regions where P. falciparum is not endemic because P. vivax, P. malariae and P. ovale are sensitive to chloroquine in most of the regions where they occur.