CXCL8   Click here for help

GtoPdb Ligand ID: 821

Synonyms: interleukin-8
Immunopharmacology Ligand
Comment: The CXCL8 (IL-8) chemokine is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. It can form homodimers and heterodimers with CXCL4.
Species: Human
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1. Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, Cervellera MN, Di Cioccio V, Cesta MC, Galliera E et al.. (2004)
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.
Proc Natl Acad Sci USA, 101 (32): 11791-6. [PMID:15282370]
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The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
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3. Giagulli C, Magiera AK, Bugatti A, Caccuri F, Marsico S, Rusnati M, Vermi W, Fiorentini S, Caruso A. (2012)
HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation.
Blood, 119 (10): 2274-83. [PMID:22262769]
4. Hall DA, Beresford IJ, Browning C, Giles H. (1999)
Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTPgammaS binding induced by IL-8 and GROalpha.
Br J Pharmacol, 126 (3): 810-8. [PMID:10188995]
5. Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI. (1992)
Characterization of two high affinity human interleukin-8 receptors.
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6. Nishimoto-Kakiuchi A, Sato I, Nakano K, Ohmori H, Kayukawa Y, Tanimura H, Yamamoto S, Sakamoto Y, Nakamura G, Maeda A et al.. (2023)
A long-acting anti-IL-8 antibody improves inflammation and fibrosis in endometriosis.
Sci Transl Med, 15 (684): eabq5858. [PMID:36812343]
7. Wilson S, Wilkinson G, Milligan G. (2005)
The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities.
J Biol Chem, 280 (31): 28663-74. [PMID:15946947]
8. Wu L, Ruffing N, Shi X, Newman W, Soler D, Mackay CR, Qin S. (1996)
Discrete steps in binding and signaling of interleukin-8 with its receptor.
J Biol Chem, 271 (49): 31202-9. [PMID:8940121]