CXCL8   

GtoPdb Ligand ID: 821

Synonyms: interleukin-8
Comment: The CXCL8 (IL-8) chemokine is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. It can form homodimers and heterodimers with CXCL4.
Species: Human
References
1. Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, Cervellera MN, Di Cioccio V, Cesta MC, Galliera E et al.. (2004)
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.
Proc. Natl. Acad. Sci. U.S.A., 101 (32): 11791-6. [PMID:15282370]
2. Bozic CR, Gerard NP, von Uexkull-Guldenband C, Kolakowski Jr LF, Conklyn MJ, Breslow R, Showell HJ, Gerard C. (1994)
The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
J. Biol. Chem., 269 (47): 29355-8. [PMID:7961909]
3. Giagulli C, Magiera AK, Bugatti A, Caccuri F, Marsico S, Rusnati M, Vermi W, Fiorentini S, Caruso A. (2012)
HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation.
Blood, 119 (10): 2274-83. [PMID:22262769]
4. Hall DA, Beresford IJ, Browning C, Giles H. (1999)
Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTPgammaS binding induced by IL-8 and GROalpha.
Br. J. Pharmacol., 126 (3): 810-8. [PMID:10188995]
5. Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI. (1992)
Characterization of two high affinity human interleukin-8 receptors.
J. Biol. Chem., 267 (23): 16283-7. [PMID:1379593]
6. Wilson S, Wilkinson G, Milligan G. (2005)
The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities.
J. Biol. Chem., 280 (31): 28663-74. [PMID:15946947]
7. Wu L, Ruffing N, Shi X, Newman W, Soler D, Mackay CR, Qin S. (1996)
Discrete steps in binding and signaling of interleukin-8 with its receptor.
J. Biol. Chem., 271 (49): 31202-9. [PMID:8940121]