CXCL8   Click here for help

GtoPdb Ligand ID: 821

Synonyms: interleukin-8
Immunopharmacology Ligand
Comment: The CXCL8 (IL-8) chemokine is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. It can form homodimers and heterodimers with CXCL4.
Species: Human
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Natural/Endogenous Targets
Target
CXCR1
CXCR2
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR1 Hs Agonist Agonist 8.1 pKd - 3
pKd 8.1 (Kd 8x10-9 M) [3]
CXCR1 Ligand is endogenous in the given species Hs Agonist Full agonist 8.8 – 9.5 pKi - 1,4-7
pKi 8.8 – 9.5 [1,4-7]
CXCR2 Ligand is endogenous in the given species Hs Agonist Full agonist 8.8 – 9.5 pKi - 1,4-7
pKi 8.8 – 9.5 [1,4-7]
CXCR2 Mm Agonist Full agonist 6.4 pKi - 2
pKi 6.4 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference