VEGF receptor tyrosine kinase inhibitor II   Click here for help

GtoPdb Ligand ID: 6056

Synonyms: AG-E-85378
PDB Ligand
Compound class: Synthetic organic
Comment: This is compound 10 in [2]. The article does not clearly indicate the speciesused to derive the VEGFR2 protein used in the kinase assays. We map this data to the human protein.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 54.02
Molecular weight 337.1
XLogP 4.15
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc(cc1)NC(=O)c1ccccc1NCc1ccncc1
Isomeric SMILES Clc1ccc(cc1)NC(=O)c1ccccc1NCc1ccncc1
InChI InChI=1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 18.4 1.0 0.0
fms related receptor tyrosine kinase 1 Flt1/FLT1(VEGFR1) Hs Inhibitor Inhibition 24.8 0.0 2.0
kinase insert domain receptor KDR/KDR(VEGFR2) Hs Inhibitor Inhibition 28.2 3.0 4.0
KIT proto-oncogene, receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 33.6 17.0 -1.0
fms related receptor tyrosine kinase 4 Flt4/FLT4 Hs Inhibitor Inhibition 44.8 0.0 0.0
platelet derived growth factor receptor beta PDGFRβ/PDGFRb Hs Inhibitor Inhibition 45.0 46.0 4.0
ret proto-oncogene Ret/RET Hs Inhibitor Inhibition 58.9 53.0 6.0
Raf-1 proto-oncogene, serine/threonine kinase c-RAF/RAF1 Hs Inhibitor Inhibition 62.6 41.0 9.0
fyn related Src family tyrosine kinase PTK5/FRK(PTK5) Hs Inhibitor Inhibition 62.8 19.0 1.0
protein tyrosine kinase 6 BRK/BRK Hs Inhibitor Inhibition 63.6 21.0 1.0
Displaying the top 10 targets  View all targets in screen »