yohimbine   Click here for help

GtoPdb Ligand ID: 102

Synonyms: Actibine® | corynine | quebrachin | yohimbin
Approved drug
yohimbine is an approved drug (FDA (no date available))
Compound class: Natural product or derivative
Comment: Yohimbine exerts actions on many receptors of the dopamine, serotonin and adrenergic families, with highest activity as an antagonist of α2-adrenoceptors.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 65.56
Molecular weight 354.19
XLogP 2.72
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COC(=O)C1C(O)CCC2C1CC1N(C2)CCc2c1[nH]c1c2cccc1
Isomeric SMILES COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
InChI Key BLGXFZZNTVWLAY-SCYLSFHTSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
α2C-adrenoceptor Primary target of this compound Hs Antagonist Antagonist 8.5 – 9.5 pKi - 4-5,14,16
⤷ pKi 8.5 – 9.5 [4-5,14,16]
α2A-adrenoceptor Primary target of this compound Hs Antagonist Antagonist 8.4 – 9.2 pKi - 4-5,14,16
⤷ pKi 8.4 – 9.2 [4-5,14,16]
5-HT1B receptor Mm Antagonist Antagonist 8.3 pKi - 11
⤷ pKi 8.3 [11]
α2B-adrenoceptor Primary target of this compound Hs Antagonist Antagonist 7.7 – 8.9 pKi - 4-5,14,16
⤷ pKi 7.7 – 8.9 [4-5,14,16]
5-HT2B receptor Hs Antagonist Antagonist 7.4 – 7.9 pKi - 3,8,18
⤷ pKi 7.4 – 7.9 [3,8,18]
5-HT1D receptor Hs Antagonist Antagonist 7.2 – 7.7 pKi - 6,9,13,19
⤷ pKi 7.2 – 7.7 [6,9,13,19]
5-HT1A receptor Hs Antagonist Antagonist 7.3 pKi - 13
⤷ pKi 7.3 [13]
5-HT2B receptor Rn Antagonist Antagonist 7.3 pKi - 17
⤷ pKi 7.3 [17]
5-HT1B receptor Hs Antagonist Antagonist 6.8 – 7.6 pKi - 13,19
⤷ pKi 6.8 – 7.6 [13,19]
5-HT1F receptor Hs Antagonist Antagonist 7.0 pKi - 1
⤷ pKi 7.0 [1]
5-ht1e receptor Hs Antagonist Antagonist 5.9 pKi - 1
⤷ pKi 5.9 [1]
5-HT7 receptor Hs Antagonist Antagonist 5.6 pKi - 2
⤷ pKi 5.6 [2]
5-HT5A receptor Mm Antagonist Antagonist 4.9 – 6.0 pKi - 12,20
⤷ pKi 4.9 – 6.0 [12,20]
5-HT5A receptor Hs Antagonist Antagonist 5.3 pKi - 15
⤷ pKi 5.3 [15]
α2C-adrenoceptor Hs Antagonist Antagonist 6.5 – 8.2 pIC50 - 7
⤷ pIC50 6.5 – 8.2 [7]
5-HT1F receptor Rn Antagonist Antagonist 6.2 pIC50 - 10
⤷ pIC50 6.2 [10]
Ligand mentioned in the following text fields
Adrenoceptors overview