mianserin   Click here for help

GtoPdb Ligand ID: 135

Synonyms: (+-)-athymil | Norval® | ORG GB 94
Approved drug
mianserin is an approved drug
Compound class: Synthetic organic
Comment: The approved drug mianserin is a racemic mixture of two enantiomers. The structure shown here does not specify stereochemistry and represents the mixture.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 6.48
Molecular weight 264.16
XLogP 3.54
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
Isomeric SMILES CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
InChI InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
InChI Key UEQUQVLFIPOEMF-UHFFFAOYSA-N
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT2C receptor Rn Antagonist Antagonist 8.8 – 9.4 pKi - 7,17
pKi 8.8 – 9.4 [7,17]
5-HT2C receptor Primary target of this compound Hs Antagonist Inverse agonist 8.3 – 9.2 pKi - 6,9,14
pKi 8.3 – 9.2 [6,9,14]
5-HT2A receptor Rn Antagonist Antagonist 8.4 – 9.0 pKi - 5,17
pKi 8.4 – 9.0 [5,17]
5-HT2A receptor Primary target of this compound Hs Antagonist Antagonist 7.7 – 9.6 pKi - 9,11,14
pKi 7.7 – 9.6 [9,11,14]
5-HT2B receptor Primary target of this compound Hs Antagonist Antagonist 7.9 – 8.8 pKi - 4,9,22
pKi 7.9 – 8.8 [4,9,22]
5-HT1B receptor Mm Antagonist Antagonist 8.3 pKi - 12
pKi 8.3 [12]
α1A-adrenoceptor Hs Antagonist Antagonist 7.6 pKi - 23
pKi 7.6 [23]
α1D-adrenoceptor Hs Antagonist Antagonist 7.5 pKi - 23
pKi 7.5 [23]
5-HT7 receptor Hs Antagonist Antagonist 7.3 – 7.6 pKi - 8
pKi 7.3 – 7.6 [8]
α1B-adrenoceptor Hs Antagonist Antagonist 7.4 pKi - 23
pKi 7.4 [23]
5-HT2B receptor Rn Antagonist Antagonist 7.3 pKi - 21
pKi 7.3 [21]
5-HT7 receptor Rn Antagonist Antagonist 7.0 – 7.4 pKi - 19-20
pKi 7.0 – 7.4 [19-20]
5-HT6 receptor Rn Antagonist Antagonist 6.9 – 7.4 pKi - 2-3,15
pKi 6.9 – 7.4 [2-3,15]
5-HT6 receptor Hs Antagonist Antagonist 6.9 – 7.3 pKi - 1,3,10
pKi 6.9 – 7.3 [1,3,10]
5-HT7 receptor Mm Antagonist Antagonist 7.0 pKi - 18
pKi 7.0 [18]
LPA1 receptor Hs Antagonist Antagonist ~7.0 pIC50 - 16
pIC50 ~7.0 (IC50 ~1x10-7 M) [16]
Selectivity at transporters
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
NET Rn Inhibitor Inhibition 7.6 pKi - 13
pKi 7.6 (Ki 2.6x10-8 M) [13]
Description: Inhibition of [3H]NE uptake into rat synaptosomes
Ligand mentioned in the following text fields