SRIF-14

Ligand id: 2019

Name: SRIF-14

Species: Human, Mouse, Rat

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Structure and Physico-chemical Properties

2D Structure
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Natural/Endogenous Targets
Target
SST1 receptor
SST2 receptor
SST3 receptor
SST4 receptor
SST5 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST2 receptor Hs Agonist Full agonist 8.9 – 10.5 pKi - 1,3,7-8,10-13,15
pKi 8.9 – 10.5 [1,3,7-8,10-13,15]
SST3 receptor Hs Agonist Full agonist 8.7 – 10.0 pKi - 1-3,7-8,10-11,13,15
pKi 8.7 – 10.0 [1-3,7-8,10-11,13,15]
SST2 receptor Mm Agonist Full agonist 8.8 – 9.6 pKi - 6
pKi 8.8 – 9.6 [6]
SST5 receptor Hs Agonist Full agonist 8.4 – 9.9 pKi - 1,3,6-8,10-13,15
pKi 8.4 – 9.9 [1,3,6-8,10-13,15]
SST1 receptor Hs Agonist Full agonist 8.6 – 9.5 pKi - 1,3,6-8,10-11,13,15
pKi 8.6 – 9.5 [1,3,6-8,10-11,13,15]
SST3 receptor Rn Agonist Full agonist 8.9 pKi - 6
pKi 8.9 [6]
SST4 receptor Hs Agonist Full agonist 8.4 – 9.3 pKi - 1,3,6-8,10-11,13,15
pKi 8.4 – 9.3 [1,3,6-8,10-11,13,15]
SST2 receptor Rn Agonist Full agonist 8.8 pKi - 6
pKi 8.8 [6]
SST5 receptor Mm Agonist Full agonist 7.7 – 9.1 pKi - 4
pKi 7.7 – 9.1 [4]
SST5 receptor Rn Agonist Full agonist 8.4 pKi - 6
pKi 8.4 [6]
SST2 receptor Rn Agonist Agonist 9.0 – 9.1 pEC50 - 5
pEC50 9.0 – 9.1 (EC50 1.02x10-9 – 7.3x10-10 M) [5]
SST3 receptor Mm Agonist Full agonist 10.1 pIC50 - 9
pIC50 10.1 [9]
SST1 receptor Rn Agonist Full agonist 8.4 pIC50 - 14
pIC50 8.4 [14]
SST4 receptor Rn Agonist Full agonist 8.2 pIC50 - 14
pIC50 8.2 [14]
Ligand mentioned in the following text fields