apomorphine   Click here for help

GtoPdb Ligand ID: 33

Synonyms: Apokyn® | Ixense® | Kynmobi® (sublingual film) | Uprima®
Approved drug PDB Ligand
apomorphine is an approved drug (EMA (2001), FDA (2004))
Compound class: Synthetic organic
Comment: Apomorphine hydrochloride is a potent dopamine-receptor agonist.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: apomorphine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 43.7
Molecular weight 267.13
XLogP 2.86
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O
Isomeric SMILES CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O
InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
InChI Key VMWNQDUVQKEIOC-CYBMUJFWSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
D4 receptor Primary target of this compound Hs Agonist Partial agonist 8.4 pKi - 3
⤷ pKi 8.4 [3]
D3 receptor Rn Agonist Partial agonist 7.7 pKi - 7
⤷ pKi 7.7 [7]
D2 receptor Rn Agonist Partial agonist 7.6 pKi - 7
⤷ pKi 7.6 [7]
α2C-adrenoceptor Hs Antagonist Antagonist 7.4 pKi - 3
⤷ pKi 7.4 [3]
α2B-adrenoceptor Hs Antagonist Antagonist 7.2 pKi - 3
⤷ pKi 7.2 [3]
D5 receptor Hs Agonist Partial agonist 6.4 – 7.8 pKi - 3,8
⤷ pKi 6.4 – 7.8 [3,8]
5-HT2C receptor Hs Antagonist Antagonist 7.0 pKi - 3
⤷ pKi 7.0 [3]
5-HT1A receptor Hs Agonist Partial agonist 6.9 pKi - 3
⤷ pKi 6.9 [3]
5-HT2A receptor Hs Antagonist Antagonist 6.9 pKi - 3
⤷ pKi 6.9 [3]
5-HT2B receptor Hs Antagonist Antagonist 6.9 pKi - 3
⤷ pKi 6.9 [3]
α2A-adrenoceptor Hs Agonist Partial agonist 6.9 pKi - 3
⤷ pKi 6.9 [3]
D3 receptor Primary target of this compound Hs Agonist Partial agonist 6.1 – 7.6 pKi - 1-4,6
⤷ pKi 6.1 – 7.6 [1-4,6]
D2 receptor Primary target of this compound Hs Agonist Partial agonist 5.7 – 7.5 pKi - 1-4,6
⤷ pKi 5.7 – 7.5 [1-4,6]
D1 receptor Hs Agonist Full agonist 5.3 – 6.2 pKi - 8-9
⤷ pKi 5.3 – 6.2 [8-9]
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPA1 Hs Activator Activation 5.1 pEC50 - 5
⤷ pEC50 5.1 Apomorphine blocks TRPA1 at 100µM [5]
Description: Calcium imaging, patch clamp
Conditions: HEK293 cells transfected with human TRPA1