RANK ligand   

GtoPdb Ligand ID: 5066

Synonyms: receptor activator of nuclear factor κB ligand | osteoclast differentiation factor (ODF) | osteoprotegerin ligand | TNFSF11
Comment: RANK ligand (TNFSF11) is a member of the tumor necrosis factor (TNF) cytokine family. It can exist in both membrane-bound and soluble forms. It is a key factor for osteoclast differentiation and activation. Osteoprotegerin acts as a decoy receptor for RANK ligand.
Species: Human
Natural/Endogenous Targets
Target
receptor activator of NF-kappa B
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
receptor activator of NF-kappa B Hs None - - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
denosumab Hs Antibody Binding >9.6 pIC50 - 1
pIC50 >9.6 (IC50 <2.3x10-10 M) [1]
Targets where the ligand is described in the comment field
Target Comment