AM2201

Ligand id: 9705

Name: AM2201

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 22
Molecular weight 359.17
XLogP 6.92
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CB1 receptor Rn Agonist Agonist 9.0 pKi - 4
pKi 9.0 (Ki 1x10-9 M) [4]
Description: Binding affinity vs. rat forebrain membranes.
CB2 receptor Mm Agonist Agonist 8.6 pKi - 4
pKi 8.6 (Ki 2.6x10-9 M) [4]
Description: Binding affinity vs. mouse spleen membranes.
CB1 receptor Hs Agonist Agonist 7.4 pEC50 - 1
pEC50 7.4 (EC50 3.8x10-8 M) [1]
CB2 receptor Hs Agonist Agonist 7.2 pEC50 - 1
pEC50 7.2 (EC50 5.88x10-8 M) [1]