amitriptyline   Click here for help

GtoPdb Ligand ID: 200

Synonyms: amitryptiline | Elavil® | Endep®
Approved drug PDB Ligand
amitriptyline is an approved drug (FDA (1961))
Compound class: Synthetic organic
Comment: Amitriptyline is a tricyclic antidepressant (TCA).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: amitriptyline

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 3.24
Molecular weight 277.18
XLogP 4.93
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN(CCC=C1c2ccccc2CCc2c1cccc2)C
Isomeric SMILES CN(CCC=C1c2ccccc2CCc2c1cccc2)C
InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
InChI Key KRMDCWKBEZIMAB-UHFFFAOYSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
H1 receptor Primary target of this compound Hs Antagonist Antagonist 9.3 pKi - 5
⤷ pKi 9.3 (Ki 5x10-10 M) [5]
Description: Antagonism of [3H]mepyramine binding
α1A-adrenoceptor Hs Antagonist Antagonist 8.2 pKi - 11
⤷ pKi 8.2 [11]
5-HT2A receptor Rn Antagonist Antagonist 8.0 – 8.4 pKi - 12,15
⤷ pKi 8.4 [12]
pKi 8.0 (Ki 1.1x10-8 M) [15]
M4 receptor Primary target of this compound Hs Antagonist Antagonist 8.1 pKi - 14
⤷ pKi 8.1 (Ki 7.2x10-9 M) [14]
5-HT2C receptor Rn Antagonist Antagonist 8.1 pKi - 15
⤷ pKi 8.1 (Ki 8x10-9 M) [15]
M2 receptor Primary target of this compound Hs Antagonist Antagonist 7.9 pKi - 14
⤷ pKi 7.9 (Ki 1.18x10-8 M) [14]
M3 receptor Primary target of this compound Hs Antagonist Antagonist 7.9 pKi - 14
⤷ pKi 7.9 (Ki 1.28x10-8 M) [14]
M1 receptor Primary target of this compound Hs Antagonist Antagonist 7.8 pKi - 14
⤷ pKi 7.8 (Ki 1.47x10-8 M) [14]
M5 receptor Primary target of this compound Hs Antagonist Antagonist 7.8 pKi - 14
⤷ pKi 7.8 (Ki 1.57x10-8 M) [14]
5-HT6 receptor Hs Antagonist Antagonist 6.9 – 7.2 pKi - 2,4,7
⤷ pKi 6.9 – 7.2 [2,4,7]
5-HT7 receptor Rn Antagonist Antagonist 6.9 – 7.0 pKi - 13
⤷ pKi 6.9 – 7.0 [13]
5-HT6 receptor Rn Antagonist Antagonist 6.5 – 7.2 pKi - 3-4,8
⤷ pKi 6.5 – 7.2 [3-4,8]
5-HT7 receptor Mm Antagonist Antagonist 6.4 pKi - 10
⤷ pKi 6.4 [10]
LPA1 receptor Hs Antagonist Antagonist ~6.2 pIC50 - 9
⤷ pIC50 ~6.2 (IC50 ~6x10-7 M) [9]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir3.2 Mm Channel blocker Antagonist 4.0 pIC50 - 6
⤷ pIC50 4.0 [6]
Voltage: -70.0 mV
Kir3.4 Mm Channel blocker Antagonist 3.6 pIC50 - 6
⤷ pIC50 3.6 [6]
Voltage: -70.0 mV
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
SERT Primary target of this compound Hs Inhibitor Inhibition 6.8 pKi - 1
⤷ pKi 6.8 (Ki 1.41x10-7 M) [1]
NET Primary target of this compound Hs Inhibitor Inhibition 6.5 pKi - 1
⤷ pKi 6.5 (Ki 3.33x10-7 M) [1]
Ligand mentioned in the following text fields
Lysophospholipid (LPA) receptors comments