cyclic AMP

Ligand id: 2352

Name: cyclic AMP

Abbreviated name: cAMP

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 164.65
Molecular weight 329.05
XLogP -2.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
OATP4C1
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
HCN1 Mm Activator Agonist 7.2 pKd - 3,16
pKd 7.2 [3,16]
Voltage: -40.0 mV
CNGA3 Rn Activator Agonist 3.6 pKd - 10
pKd 3.6 [10]
Voltage: -80.0 mV
CNGA3 Hs Activator Agonist 2.9 pKd - 15,17
pKd 2.9 [15,17]
Voltage: -60.0 – 80.0 mV
HCN2 Mm Activator Agonist 6.3 pKi - 12
pKi 6.3 [12]
Voltage: -40.0 mV
CNGA2 Rn Activator Agonist 4.2 – 4.3 pEC50 - 1-2,11,14
pEC50 4.2 – 4.3 (EC50 6.16x10-5 – 4.57x10-5 M) [1-2,11,14]
Voltage: -80.0 – 100.0 mV
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields