Synonyms: AEA | arachidonoyl ethanolamide | N-arachidonoylethanolamine
Compound class:
Metabolite
Comment: Anandamide is an endogenous cannabinoid neurotransmitter found in animal and human organs, especially in the brain. It activates the cannabinoid receptors CB1 and CB2. Anandamide is also known to be an endogenous activator of the TRPV1 cation channel [3,13], which is involved in regulation of body temperature and nociception.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Natural/Endogenous Targets | ||||
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||
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Selectivity at GPCRs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Selectivity at ion channels | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Rank order of affinity at Fatty acid amide hydrolase | anandamide > oleamide > N-oleoylethanolamide > N-palmitoylethanolamine | 19 |
Rank order of affinity at Fatty acid amide hydrolase-2 | oleamide > N-oleoylethanolamide > anandamide > N-palmitoylethanolamine | 19 |
Rank order of affinity at N-Acylethanolamine acid amidase | N-palmitoylethanolamine > MEA > SEA ≥ N-oleoylethanolamide > anandamide | 18 |
Endogenous substrates at monoacylglycerol lipase | 2-oleoyl glycerol = 2-arachidonoylglycerol >> anandamide | 5 |
Potency order of endogenous ligands at GPR119 | N-oleoylethanolamide, N-palmitoylethanolamine > SEA (anandamide is ineffective) | 9 |
Targets where the ligand is described in the comment field | |
Target | Comment |
CYP4X1 | Converts anandamide to 14,15-epoxyeicosatrienoic ethanolamide [17]. May influence age of onset of sporadic Creutzfeldt-Jakob diseases [10]. |
Ligand mentioned in the following text fields |
Cannabinoid receptors overview |
Endocannabinoid turnover overview |
Cannabinoid receptors comments |
Glycine transporter subfamily comments |
Phosphatidylcholine-specific phospholipase D comments |
Transient Receptor Potential channels (TRP) comments |