ruthenium red   

GtoPdb Ligand ID: 2432

Synonyms: ammoniated ruthenium oxychloride
Compound class: Inorganic
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPM6 Hs Channel blocker Antagonist - - 1x10-7 - 1x10-5 10
Conc range: 1x10-7 - 1x10-5 M [10]
Voltage: -120.0 – -20.0 mV
TRPV4 Mm Channel blocker Antagonist - - 1x10-6 11
Conc range: 1x10-6 M [11]
Voltage: 0.0 mV
TRPM6 Hs Channel blocker - 7.0 pIC50 -
pIC50 7.0 (IC50 1x10-7 M)
Voltage: -120.0 mV
TRPV1 Hs Channel blocker Antagonist 7.0 pIC50 - 6
pIC50 7.0 [6]
Voltage: -60.0 mV
TRPV5 Oc Channel blocker Inhibition 6.9 pIC50 - 8
pIC50 6.9 (IC50 1.11x10-7 M) [8]
Voltage: -150.0 – 100.0 mV
TRPV5 Hs Channel blocker - 6.9 pIC50 -
pIC50 6.9 (IC50 1.21x10-7 M)
TRPV1 Hs Channel blocker - 6.7 – 7.0 pIC50 -
pIC50 6.7 – 7.0 (IC50 2.2x10-7 – 9x10-8 M)
TRPV1 Rn Channel blocker Antagonist 6.7 pIC50 - 6
pIC50 6.7 [6]
Voltage: -60.0 mV
TRPV4 Rn Channel blocker Inhibition 6.7 pIC50 - 2
pIC50 6.7 [2]
TRPV2 Hs Channel blocker - 6.2 pIC50 -
pIC50 6.2 (IC50 6x10-7 M)
TRPV2 Mm Channel blocker Antagonist 6.2 pIC50 - 1
pIC50 6.2 [1]
Voltage: -40.0 mV
K2P9.1 N/A Channel blocker - 6.2 pIC50 -
pIC50 6.2
TRPV3 Mm Channel blocker Inhibition 6.0 pIC50 - 9
pIC50 6.0 [9]
Description: Patch clamp electrophysiology
TRPA1 Mm Channel blocker Inhibition 5.5 pIC50 - 7
pIC50 5.5 (IC50 3.55x10-6 M) [7]
Voltage: -80.0 mV
CatSper1 Mm Channel blocker Inhibition 5.0 pIC50 - 5
pIC50 5.0 (IC50 1x10-5 M) [5]
Description: Whole cell patch clamp
CatSper2 Mm Channel blocker Antagonist 5.0 pIC50 - 4
pIC50 5.0 (IC50 1x10-5 M) [4]
Description: Whole cell patch clamp.
CatSper3 Mm Channel blocker Antagonist 5.0 pIC50 - 5
pIC50 5.0 (IC50 1x10-5 M) [5]
Description: Whole cell patch clamp electrophysiology.
CatSper4 Mm Channel blocker Antagonist 5.0 pIC50 - 5
pIC50 5.0 (IC50 1x10-5 M) [5]
Description: Whole cell patch clamp electrophysiology.
TRPV6 Mm Channel blocker Antagonist 5.0 pIC50 - 3
pIC50 5.0 (IC50 9x10-6 M) [3]
Voltage: -80.0 mV
K2P9.1 Hs Inhibitor - - - -
RyR1 Hs Channel blocker - - - -
RyR2 Hs Channel blocker - - - -
RyR3 Hs Channel blocker - - - -
Targets where the ligand is described in the comment field
Target Comment