guanylpirenzepine

Ligand id: 3276

Name: guanylpirenzepine

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 124.1
Molecular weight 379.18
XLogP 1.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
M5 receptor ? Antagonist Antagonist 6.8 pKd - 2
pKd 6.8 (Kd 1.75x10-7 M) [2]
M1 receptor Rn Antagonist Antagonist 7.3 – 7.6 pKi - 1,3
pKi 7.3 – 7.6 [1,3]
M3 receptor Rn Antagonist Antagonist 6.2 pKi - 3
pKi 6.2 [3]
M4 receptor Rn Antagonist Antagonist 6.2 pKi - 3
pKi 6.2 [3]
M2 receptor Rn Antagonist Antagonist 5.3 pKi - 3
pKi 5.3 [3]