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fms related receptor tyrosine kinase 3

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1807

Nomenclature: fms related receptor tyrosine kinase 3

Abbreviated Name: FLT3

Family: Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 993 13q12.2 FLT3 fms related receptor tyrosine kinase 3
Mouse 1 1000 5 G3 Flt3 FMS-like tyrosine kinase 3
Rat - 1000 12p11 Flt3 Fms related receptor tyrosine kinase 3
Previous and Unofficial Names Click here for help
CD135 | Fetal liver kinase 2 | FL cytokine receptor | FLK2 | FMS-like tyrosine kinase 3 | fms-related tyrosine kinase 3 | fms related tyrosine kinase 3 | STK1
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of a human Flt3 ligand-receptor ternary complex
PDB Id:  3QS7
Resolution:  4.3Å
Species:  Human
References:  57
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of FLT3
PDB Id:  1RJB
Resolution:  2.1Å
Species:  Human
References:  20
Enzyme Reaction Click here for help
EC Number: 2.7.10.1
Natural/Endogenous Ligands Click here for help
Fms-related tyrosine kinase 3 ligand {Sp: Human}

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AC710 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.3 pKd 34
pKd 9.3 (Kd 5x10-10 M) [34]
linifanib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.2 pKd 9
pKd 9.2 (Kd 6.3x10-10 M) [9]
dovitinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.2 pKd 9
pKd 9.2 (Kd 6.4x10-10 M) [9]
crenolanib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 9.1 pKd 22
pKd 9.1 (Kd 7.4x10-10 M) [22]
AST-487 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.1 pKd 9
pKd 9.1 (Kd 7.9x10-10 M) [9]
quizartinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.8 – 8.9 pKd 6,9
pKd 8.8 – 8.9 (Kd 1.6x10-9 – 1.3x10-9 M) [6,9]
tandutinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 pKd 9
pKd 8.5 (Kd 3x10-9 M) [9]
compound 5e [PMID: 28580438] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 8.4 pKd 23
pKd 8.4 (Kd 3.6x10-9 M) [23]
Description: Measured using the Z′-LYTE Kinase Assay Kit and wild type FLT3.
lestaurtinib Small molecule or natural product Primary target of this compound Immunopharmacology Ligand Hs Inhibition 8.1 pKd 9
pKd 8.1 (Kd 8.5x10-9 M) [9]
midostaurin Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.0 pKd 9
pKd 8.0 (Kd 1.1x10-8 M) [9]
RG-1530 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.0 pKd 55
pKd 8.0 (Kd 1.1x10-8 M) [55]
KW-2449 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.8 pKd 9
pKd 7.8 (Kd 1.5x10-8 M) [9]
belizatinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.4 pKd 33
pKd 7.4 (Kd 4.2x10-8 M) [33]
Description: Binding affinity in vitro.
UNC4203 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 7.8 pKi 72
pKi 7.8 (Ki 1.614x10-8 M) [72]
AST-487 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.9 pKi 62
pKi 6.9 (Ki 1.2x10-7 M) [62]
Description: Inhibition of wild type FLT3
gilteritinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition ~9.5 pIC50 31
pIC50 ~9.5 (IC50 ~3x10-10 M) [31]
G749 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.4 pIC50 30
pIC50 9.4 (IC50 4x10-10 M) [30]
Gö 6976 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 9.1 pIC50 69
pIC50 9.1 (IC50 7x10-10 M) [69]
Description: Inhibitory activity against recombinant FLT3 in an in vitro kinase assay.
TTT-3002 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pIC50 35
pIC50 9.1 (IC50 7.2x10-10 M) [35]
Description: Inhibition of FLT3 phosphorylation in Molm14 human leukemia cells that carry the FLT3/ITD activation mutation
compound 8i [PMID: 22765894] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pIC50 70
pIC50 9.1 (IC50 8x10-10 M) [70]
compound 8h [PMID: 22765894] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.1 pIC50 27
pIC50 9.1 (IC50 8.5x10-10 M) [27]
dorsomorphin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition >9.0 pIC50 36
pIC50 >9.0 (IC50 <1x10-9 M) [36]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
RGB-286638 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.0 pIC50 7
pIC50 9.0 (IC50 1x10-9 M) [7]
ilorasertib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.0 pIC50 16
pIC50 9.0 (IC50 1x10-9 M) [16]
Description: Measuring inhibition of kinase activity in a biochemical assay.
dovitinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 – 9.0 pIC50 50,56
pIC50 8.5 – 9.0 (IC50 3x10-9 – 1x10-9 M) [50,56]
compound 2c [PMID: 24900538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.7 pIC50 59
pIC50 8.7 (IC50 2.1x10-9 M) [59]
ENMD-2076 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.5 pIC50 49
pIC50 8.5 (IC50 3x10-9 M) [49]
linifanib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pIC50 2
pIC50 8.4 (IC50 4x10-9 M) [2]
URMC-099 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pIC50 18
pIC50 8.4 (IC50 4x10-9 M) [18]
compound 18e [PMID: 31670517] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 8.4 pIC50 68
pIC50 8.4 (IC50 4x10-9 M) [68]
quizartinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.4 pIC50 71
pIC50 8.4 (IC50 4.2x10-9 M) [71]
mivavotinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.3 pIC50 29
pIC50 8.3 (IC50 4.6x10-9 M) [29]
Description: In vitro potency
AKN-028 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.2 pIC50 12
pIC50 8.2 (IC50 6x10-9 M) [12]
sunitinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.2 pIC50 26
pIC50 8.2 (IC50 6.5x10-9 M) [26]
KW-2449 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.2 pIC50 53
pIC50 8.2 (IC50 6.6x10-9 M) [53]
sitravatinib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.1 pIC50 47
pIC50 8.1 (IC50 8x10-9 M) [47]
Description: In a biochemical enzyme activity assay.
compound 7d [PMID: 29672049] Small molecule or natural product Immunopharmacology Ligand Hs Inhibition 7.9 pIC50 21
pIC50 7.9 (IC50 1.3x10-8 M) [21]
Description: In a biochemical assay.
MELK-TI Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pIC50 24
pIC50 7.7 (IC50 1.8x10-8 M) [24]
Description: Measured in a MIllipore kinase screening panel assay
tafetinib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pIC50 58
pIC50 7.7 (IC50 2.08x10-8 M) [58]
Description: In a radiometric biochemical protein kinase assay.
pacritinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pIC50 64
pIC50 7.7 (IC50 2.2x10-8 M) [64]
MK-2461 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pIC50 44
pIC50 7.7 (IC50 2.2x10-8 M) [44]
JNJ-28312141 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.5 pIC50 39
pIC50 7.5 (IC50 3x10-8 M) [39]
merestinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 7.5 pIC50 67
pIC50 7.5 (IC50 3.1x10-8 M) [67]
Description: Inhibition of in vitro biochemical activity by EMD Millipore assay.
zotiraciclib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.3 – 7.7 pIC50 17,65
pIC50 7.3 – 7.7 (IC50 5.6x10-8 – 1.9x10-8 M) [17,65]
Flt-3 inhibitor II Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.5 pIC50 38
pIC50 7.5 (IC50 3.3x10-8 M) [38]
Flt-3 inhibitor Small molecule or natural product Primary target of this compound Hs Inhibition 7.4 pIC50 45
pIC50 7.4 (IC50 4.2x10-8 M) [45]
SGI-1776 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.4 pIC50 11
pIC50 7.4 (IC50 4.4x10-8 M) [11]
sorafenib Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.2 – 7.5 pIC50 63,70
pIC50 7.5 (IC50 3.3x10-8 M) [70]
pIC50 7.2 (IC50 5.8x10-8 M) [63]
Flt-3 inhibitor III Small molecule or natural product Primary target of this compound Hs Inhibition 7.3 pIC50 13
pIC50 7.3 (IC50 5x10-8 M) [13]
ceritinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.2 pIC50 41
pIC50 7.2 (IC50 6x10-8 M) [41]
PF-562271 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.0 pIC50 51
pIC50 7.0 (IC50 9.7x10-8 M) [51]
compound 14k [PMID: 21982499] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 48
pIC50 7.0 (IC50 1.04x10-7 M) [48]
BMS-690514 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 40
pIC50 7.0 (IC50 1.1x10-7 M) [40]
BAY-985 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.9 pIC50 32
pIC50 6.9 (IC50 1.23x10-7 M) [32]
pexidartinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.8 pIC50 54
pIC50 6.8 (IC50 1.6x10-7 M) [54]
edicotinib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.7 pIC50 15
pIC50 6.7 (IC50 1.9x10-7 M) [15]
tandutinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.7 pIC50 25
pIC50 6.7 (IC50 2.2x10-7 M) [25]
GTP-14564 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.5 pIC50 43
pIC50 6.5 (IC50 3x10-7 M) [43]
NMS-P937 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.3 pIC50 4
pIC50 6.3 (IC50 5.1x10-7 M) [4]
AST-487 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 5.2x10-7 M) [1]
midostaurin Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 6.3 pIC50 61
pIC50 6.3 (IC50 5.28x10-7 M) [61]
cediranib Small molecule or natural product Click here for species-specific activity table Hs Inhibition <6.0 pIC50 60
pIC50 <6.0 (IC50 >1x10-6 M) [60]
compound 1 [Cruz-López et al., 2019] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.3 pIC50 8
pIC50 4.3 (IC50 5.35x10-5 M) [8]
Inhibitor Comments
Cyclin-dependent kinase 1 (CDK1) which shares a phenylalanine gate keeper residue in the analogous position to that in FLT3, is significantly inhibited by Flt-3 inhibitor III but with a much lower IC50 value of 2100μM [13]. c-Kit and KDR (VEGFR-2) which contain a cysteine residue at the position corresponding to Cys828 important in the binding pocket of FLT3, are also inhibited by this compound, with IC50 values of 260 and 910μM respectively [13].
G-749 inhibits FLT3 mutant D835Y with an IC50 value of 0.6nM [30].
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 9,66

Key to terms and symbols Click column headers to sort
Target used in screen: FLT3
Ligand Sp. Type Action Value Parameter
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 9.4 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 9.3 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 9.2 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 9.2 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.1 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 9.1 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.1 pKd
quizartinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.9 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.5 pKd
tandutinib Small molecule or natural product Hs Inhibitor Inhibition 8.5 pKd
Target used in screen: FLT3(D835H)
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.9 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 8.6 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.6 pKd
quizartinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.4 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.4 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.3 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
Target used in screen: FLT3(D835Y)
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.4 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 8.8 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 8.2 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.2 pKd
Target used in screen: FLT3(ITD)
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.3 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 9.0 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 8.8 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 8.7 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 8.4 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 8.4 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.1 pKd
Target used in screen: FLT3(K663Q)
Ligand Sp. Type Action Value Parameter
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 9.7 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 9.3 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 9.1 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.1 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 9.0 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.9 pKd
tandutinib Small molecule or natural product Hs Inhibitor Inhibition 8.8 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.7 pKd
quizartinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
Target used in screen: FLT3(N841I)
Ligand Sp. Type Action Value Parameter
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 8.9 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.8 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.8 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 8.6 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.6 pKd
quizartinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.4 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.4 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
Target used in screen: FLT3(R834Q)
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.7 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 9.1 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.4 pKd
quizartinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.3 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 8.1 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 8.1 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.0 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.0 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.9 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 7.8 pKd
Target used in screen: FLT3-autoinhibited
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.0 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.8 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 6.9 pKd
lestaurtinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
quizartinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.4 pKd
midostaurin Small molecule or natural product Approved drug