Tumour necrosis factor (TNF) receptor family | Catalytic receptors

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Tumour necrosis factor (TNF) receptor family

Tumour necrosis factor (TNF) receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dysregulated TNFR signalling is associated with many inflammatory disorders, including some forms of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases and for cancer immunotherapy [1-2,7].

Receptors

1888

TNFR1 (tumor necrosis factor receptor 1 / TNFRSF1A) C Show summary »« Hide summary More detailed page go icon to follow link

TNFR2 (tumor necrosis factor receptor 2 / TNFRSF1B) C Show summary »« Hide summary More detailed page go icon to follow link

lymphotoxin β receptor / TNFRSF3 C Show summary »« Hide summary More detailed page go icon to follow link

OX40 / TNFRSF4 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1873

Nomenclature

OX40

Systematic nomenclature

TNFRSF4

Previous and unofficial names

Genes

TNFRSF4 (Hs), Tnfrsf4 (Mm), Tnfrsf4 (Rn)

Ensembl ID

ENSG00000186827 (Hs), ENSMUSG00000029075 (Mm), ENSRNOG00000020106 (Rn)

UniProtKB AC

P43489 (Hs), P47741 (Mm), P15725 (Rn)

Adaptor proteins

TRAF1, TRAF2, TRAF3, TRAF5

Endogenous ligands

OX-40 ligand (TNFSF4, P23510)

Ligands

compound 1 [PMID: 24930776] (Binding) pIC₅₀ 5.9 [8]

Comment

The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [10]

CD40 / TNFRSF5 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1874

Nomenclature

CD40

Systematic nomenclature

TNFRSF5

Previous and unofficial names

CD40 molecule, TNF receptor superfamily member 5 | TNFRSF5

Genes

CD40 (Hs), Cd40 (Mm), Cd40 (Rn)

Ensembl ID

ENSG00000101017 (Hs), ENSMUSG00000017652 (Mm), ENSRNOG00000018488 (Rn)

UniProtKB AC

P25942 (Hs), P27512 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Endogenous ligands

CD40 ligand (CD40LG, P29965)

Fas / TNFRSF6 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1875

Nomenclature

Fas

Systematic nomenclature

TNFRSF6

Previous and unofficial names

Genes

FAS (Hs), Fas (Mm), Fas (Rn)

Ensembl ID

ENSG00000026103 (Hs), ENSMUSG00000024778 (Mm), ENSRNOG00000019142 (Rn)

UniProtKB AC

P25445 (Hs), P25446 (Mm), Q63199 (Rn)

Adaptor proteins

FADD

Endogenous ligands

Fas ligand (FASLG, P48023)

decoy receptor 3 / TNFRSF6B C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2322
Nomenclature	decoy receptor 3
Systematic nomenclature	TNFRSF6B
Previous and unofficial names	DCR3 \| decoy receptor for Fas ligand \| tumor necrosis factor receptor superfamily, member 6b, decoy \| tumor necrosis factor receptor superfamily member 6b
Genes	TNFRSF6B (Hs)
Ensembl ID	ENSG00000243509 (Hs)
UniProtKB AC	O95407 (Hs)
Comment	Decoy receptor for LIGHT (TNFSF14, O43557), TL1A (TNFSF15, O95150) and Fas ligand (FASLG, P48023).

CD27 / TNFRSF7 C Show summary »« Hide summary More detailed page go icon to follow link

CD30 / TNFRSF8 C Show summary »« Hide summary More detailed page go icon to follow link

4-1BB / TNFRSF9 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1878

Nomenclature

4-1BB

Systematic nomenclature

TNFRSF9

Previous and unofficial names

ILA | CD137 | Ly63 | tumor necrosis factor receptor superfamily, member 9 | tumor necrosis factor receptor superfamily

Genes

TNFRSF9 (Hs), Tnfrsf9 (Mm), Tnfrsf9 (Rn)

Ensembl ID

ENSG00000049249 (Hs), ENSMUSG00000028965 (Mm), ENSRNOG00000036942 (Rn)

UniProtKB AC

Q07011 (Hs), P20334 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3

Endogenous ligands

4-1BB ligand (TNFSF9, P41273)

DR4 (death receptor 4 / TNFRSF10A) C Show summary »« Hide summary

Target Id

1879

Nomenclature

death receptor 4

Systematic nomenclature

TNFRSF10A

Common abbreviation

DR4

Previous and unofficial names

Genes

TNFRSF10A (Hs)

Ensembl ID

ENSG00000104689 (Hs)

UniProtKB AC

O00220 (Hs)

Adaptor proteins

FADD

Endogenous ligands

TRAIL (TNFSF10, P50591)

Agonists

SC-67655 [4]

aponermin [3]

DR5 (death receptor 5 / TNFRSF10B) C Show summary »« Hide summary

Target Id

1880

Nomenclature

death receptor 5

Systematic nomenclature

TNFRSF10B

Common abbreviation

DR5

Previous and unofficial names

Genes

TNFRSF10B (Hs), Tnfrsf10b (Mm), Tnfrsf10b (Rn)

Ensembl ID

ENSG00000120889 (Hs), ENSMUSG00000022074 (Mm), ENSRNOG00000038483 (Rn)

UniProtKB AC

O14763 (Hs), Q9QZM4 (Mm)

Adaptor proteins

FADD

Endogenous agonists

TRAIL (TNFSF10, P50591) [12]

Agonists

aponermin [3]

Antibodies

tigatuzumab (Agonist) pK_d ~8.5 [12]

decoy receptor 1 / TNFRSF10C C Show summary »« Hide summary

Target Id	2323
Nomenclature	decoy receptor 1
Systematic nomenclature	TNFRSF10C
Previous and unofficial names	antagonist decoy receptor for TRAIL/Apo-2L \| lymphocyte inhibitor of TRAIL \| TNF-related apoptosis-inducing ligand receptor 3 \| TRAIL receptor 3 \| TRAILR3 \| tumor necrosis factor receptor superfamily member 10C \| CD263 \| DcR1 \| LIT \| tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain \| tumor necrosis factor receptor superfamily member 10c
Genes	TNFRSF10C (Hs)
Ensembl ID	ENSG00000173535 (Hs)
UniProtKB AC	O14798 (Hs)
Comment	Decoy receptor for TRAIL (TNFSF10, P50591).

decoy receptor 2 / TNFRSF10D C Show summary »« Hide summary

Target Id	2324
Nomenclature	decoy receptor 2
Systematic nomenclature	TNFRSF10D
Previous and unofficial names	CD264 \| DcR2 \| TNF-related apoptosis-inducing ligand receptor 4 \| TRAIL receptor 4 \| TRAILR4 \| TRUNDD \| tumor necrosis factor receptor superfamily member 10D \| tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain \| tumor necrosis factor receptor superfamily member 10d
Genes	TNFRSF10D (Hs)
Ensembl ID	ENSG00000173530 (Hs)
UniProtKB AC	Q9UBN6 (Hs)
Comment	Decoy receptor for TRAIL (TNFSF10, P50591).

RANK (receptor activator of NF-kappa B / TNFRSF11A) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1881

Nomenclature

receptor activator of NF-kappa B

Systematic nomenclature

TNFRSF11A

Common abbreviation

RANK

Previous and unofficial names

Genes

TNFRSF11A (Hs), Tnfrsf11a (Mm), Tnfrsf11a (Rn)

Ensembl ID

ENSG00000141655 (Hs), ENSMUSG00000026321 (Mm), ENSRNOG00000015615 (Rn)

UniProtKB AC

Q9Y6Q6 (Hs), O35305 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Endogenous ligands

RANK ligand (TNFSF11, O14788)

OPG (osteoprotegerin / TNFRSF11B) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1882
Nomenclature	osteoprotegerin
Systematic nomenclature	TNFRSF11B
Common abbreviation	OPG
Previous and unofficial names	osteoclastogenesis inhibitory factor \| TR1 \| tumor necrosis factor receptor superfamily, member 11b \| tumor necrosis factor receptor superfamily member 11b \| tumor necrosis factor receptor superfamily
Genes	TNFRSF11B (Hs), Tnfrsf11b (Mm), Tnfrsf11b (Rn)
Ensembl ID	ENSG00000164761 (Hs), ENSMUSG00000063727 (Mm), ENSRNOG00000008336 (Rn)
UniProtKB AC	O00300 (Hs), O08712 (Mm), O08727 (Rn)
Comment	Acts as a decoy receptor for RANK ligand (TNFSF11, O14788) and possibly for TRAIL (TNFSF10, P50591).

DR3 (death receptor 3 / TNFRSF25) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1883

Nomenclature

death receptor 3

Systematic nomenclature

TNFRSF25

Common abbreviation

DR3

Previous and unofficial names

Genes

TNFRSF25 (Hs), Tnfrsf25 (Mm), Tnfrsf25 (Rn)

Ensembl ID

ENSG00000215788 (Hs), ENSMUSG00000024793 (Mm), ENSRNOG00000021814 (Rn)

UniProtKB AC

Q93038 (Hs)

Adaptor proteins

TRADD

Endogenous ligands

TL1A (TNFSF15, O95150)

Comment

The only known TNFSF ligand for DR3 is TNF-like protein 1A (TL1A) [9].

TWEAK receptor / TNFRSF12A C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1884

Nomenclature

TWEAK receptor

Systematic nomenclature

TNFRSF12A

Previous and unofficial names

Genes

TNFRSF12A (Hs), Tnfrsf12a (Mm), Tnfrsf12a (Rn)

Ensembl ID

ENSG00000006327 (Hs), ENSMUSG00000023905 (Mm), ENSRNOG00000003546 (Rn)

UniProtKB AC

Q9NP84 (Hs), Q9CR75 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3

Endogenous ligands

TWEAK (TNFSF12, O43508)

TACI / TNFRSF13B C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1885

Nomenclature

TACI

Systematic nomenclature

TNFRSF13B

Previous and unofficial names

CD267 | tumor necrosis factor receptor superfamily, member 13B | Transmembrane activator and CAML interactor | tumor necrosis factor receptor superfamily member 13B | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 13b

Genes

TNFRSF13B (Hs), Tnfrsf13b (Mm), Tnfrsf13b (Rn)

Ensembl ID

ENSG00000240505 (Hs), ENSMUSG00000010142 (Mm), ENSRNOG00000002304 (Rn)

UniProtKB AC

O14836 (Hs), Q9ET35 (Mm)

Adaptor proteins

TRAF2, TRAF5, TRAF6

Endogenous ligands

APRIL (TNFSF13, O75888)

BAFF (TNFSF13B, Q9Y275)

BAFF-R (BAFF receptor / TNFRSF13C) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1886

Nomenclature

BAFF receptor

Systematic nomenclature

TNFRSF13C

Common abbreviation

BAFF-R

Previous and unofficial names

Genes

TNFRSF13C (Hs), Tnfrsf13c (Mm), Tnfrsf13c (Rn)

Ensembl ID

ENSG00000159958 (Hs), ENSMUSG00000068105 (Mm), ENSRNOG00000007664 (Rn)

UniProtKB AC

Q96RJ3 (Hs), Q9D8D0 (Mm)

Adaptor proteins

TRAF3

Endogenous ligands

BAFF (TNFSF13B, Q9Y275)

HVEM (herpes virus entry mediator / TNFRSF14) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1887

Nomenclature

herpes virus entry mediator

Systematic nomenclature

TNFRSF14

Common abbreviation

HVEM

Previous and unofficial names

Genes

TNFRSF14 (Hs), Tnfrsf14 (Mm), Tnfrsf14 (Rn)

Ensembl ID

ENSG00000157873 (Hs), ENSMUSG00000042333 (Mm), ENSRNOG00000013820 (Rn)

UniProtKB AC

Q92956 (Hs)

Adaptor proteins

TRAF2, TRAF3, TRAF5

Endogenous ligands

B and T lymphocyte attenuator (BTLA, Q7Z6A9)

lymphotoxin-α (LTA, P01374)

LIGHT (TNFSF14, O43557)

nerve growth factor receptor / TNFRSF16 C Show summary »« Hide summary

Target Id

1888

Nomenclature

nerve growth factor receptor

Systematic nomenclature

TNFRSF16

Previous and unofficial names

Genes

NGFR (Hs), Ngfr (Mm), Ngfr (Rn)

Ensembl ID

ENSG00000064300 (Hs), ENSMUSG00000000120 (Mm), ENSRNOG00000005392 (Rn)

UniProtKB AC

P08138 (Hs), Q9Z0W1 (Mm), P07174 (Rn)

Adaptor proteins

TRAF2, TRAF4, TRAF6

Endogenous ligands

NGF (NGF, P01138) pIC₅₀ 6.0 [5]

BDNF (BDNF, P23560)

neurotrophin-3 (NTF3, P20783)

neurotrophin-4 (NTF4, P34130)

Ligands

LM11A-31 (Binding) [6]

Comment

One of the two receptor types for the neurotrophins (factors that stimulate neuronal cell survival and differentiation), the others being the tropomyosin-related kinases (Trks). NGFR functions as a molecular switch that regulates neuronal survival and synaptic integrity, and which operates in a highly context-dependent manner. Mature neurotrophins bind preferentially to Trks and NGFR (p75NTR); proneurotrophins interact with NGFR and sortilin. Unliganded and proneurotrophin-liganded NGFR induce degeneration of synapses and neuronal death. In contrast, when bound to mature neurotrophins NGFR forms a co-receptor with Trks that promotes neuronal survival.

BCMA (B cell maturation antigen / TNFRSF17) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1889

Nomenclature

B cell maturation antigen

Systematic nomenclature

TNFRSF17

Common abbreviation

BCMA

Previous and unofficial names

tumor necrosis factor receptor superfamily, member 17 | BCM | CD269 | TNFRSF13a | tumor necrosis factor receptor superfamily

Genes

TNFRSF17 (Hs), Tnfrsf17 (Mm), Tnfrsf17 (Rn)

Ensembl ID

ENSG00000048462 (Hs), ENSMUSG00000022496 (Mm), ENSRNOG00000021987 (Rn)

UniProtKB AC

Q02223 (Hs), O88472 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Endogenous ligands

APRIL (TNFSF13, O75888)

BAFF (TNFSF13B, Q9Y275)

GITR (glucocorticoid-induced TNF receptor / TNFRSF18) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1890

Nomenclature

glucocorticoid-induced TNF receptor

Systematic nomenclature

TNFRSF18

Common abbreviation

GITR

Previous and unofficial names

Genes

TNFRSF18 (Hs), Tnfrsf18 (Mm), Tnfrsf18 (Rn)

Ensembl ID

ENSG00000186891 (Hs), ENSMUSG00000041954 (Mm), ENSRNOG00000022012 (Rn)

UniProtKB AC

Q9Y5U5 (Hs), O35714 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3, SIVA

Endogenous ligands

TL6 (TNFSF18, Q9UNG2)

TAJ (toxicity and JNK inducer / TNFRSF19) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1891

Nomenclature

toxicity and JNK inducer

Systematic nomenclature

TNFRSF19

Common abbreviation

TAJ

Previous and unofficial names

Genes

TNFRSF19 (Hs), Tnfrsf19 (Mm), Tnfrsf19 (Rn)

Ensembl ID

ENSG00000127863 (Hs), ENSMUSG00000060548 (Mm), ENSRNOG00000014265 (Rn)

UniProtKB AC

Q9NS68 (Hs), Q9JLL3 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3, TRAF5

Endogenous ligands

lymphotoxin-α (LTA, P01374)

Comment

Believed to be essential during embryonic development.

RELT / TNFRSF19L C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1892
Nomenclature	RELT
Systematic nomenclature	TNFRSF19L
Previous and unofficial names	Receptor expressed in lymphoid tissues \| tumor necrosis factor receptor superfamily, member 19-like \| RELT tumor necrosis factor receptor \| TNFRSF19L \| RELT, TNF receptor
Genes	RELT (Hs), Relt (Mm), Relt (Rn)
Ensembl ID	ENSG00000054967 (Hs), ENSMUSG00000008318 (Mm), ENSRNOG00000025075 (Rn)
UniProtKB AC	Q969Z4 (Hs), Q8BX43 (Mm)
Adaptor proteins	TRAF1
Comment	Abundant in hematologic tissues. Selective receptor for TNF receptor-associated factor 1 (TRAF1). Activates the NF-κB pathway.

DR6 (death receptor 6 / TNFRSF21) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1893
Nomenclature	death receptor 6
Systematic nomenclature	TNFRSF21
Common abbreviation	DR6
Previous and unofficial names	tumor necrosis factor receptor superfamily, member 21 \| CD358 \| tumor necrosis factor receptor superfamily
Genes	TNFRSF21 (Hs), Tnfrsf21 (Mm), Tnfrsf21 (Rn)
Ensembl ID	ENSG00000146072 (Hs), ENSMUSG00000023915 (Mm), ENSRNOG00000011517 (Rn)
UniProtKB AC	O75509 (Hs), Q9EPU5 (Mm)
Adaptor proteins	TRADD

TNFRSF22 C Show summary »« Hide summary

Target Id	1894
Nomenclature	TNFRSF22
Previous and unofficial names	tumor necrosis factor receptor superfamily, member 22 \| SOBa \| Tnfrh2
Genes	Tnfrsf22 (Mm)
Ensembl ID	ENSMUSG00000010751 (Mm)
UniProtKB AC	Q9ER62 (Mm)
Comment	Only identified in mouse to date. A potential decoy receptor for the cytotoxic ligand TNFSF10/TRAIL. Does not contain a cytoplasmic death domain so does not induce apoptosis, and does not activate the NF-κB signalling pathway.

TNFRSF23 C Show summary »« Hide summary

Target Id	1895
Nomenclature	TNFRSF23
Previous and unofficial names	Tnfrh1 \| tumor necrosis factor receptor superfamily, member 23 \| tumor necrosis factor receptor superfamily
Genes	Tnfrsf23 (Mm)
Ensembl ID	ENSMUSG00000037613 (Mm)
UniProtKB AC	Q9ER63 (Mm)
Comment	Only identified in mouse to date. A potential decoy receptor for the cytotoxic ligand TNFSF10/TRAIL. Does not contain a cytoplasmic death domain so does not induce apoptosis, and does not activate the NF-κB signalling pathway.

ectodysplasin A2 isoform receptor / TNFRS27 C Show summary »« Hide summary

Target Id

1896

Nomenclature

ectodysplasin A2 isoform receptor

Systematic nomenclature

TNFRS27

Previous and unofficial names

tumor necrosis factor receptor superfamily member 27 | EDA-A2 receptor | TNFRSF27 | XEDAR | X-linked ectodysplasin-A2 receptor

Genes

EDA2R (Hs), Eda2r (Mm), Eda2r (Rn)

Ensembl ID

ENSG00000131080 (Hs), ENSMUSG00000034457 (Mm), ENSRNOG00000013018 (Rn)

UniProtKB AC

Q9HAV5 (Hs), Q8BX35 (Mm)

Adaptor proteins

TRAF1, TRAF3, TRAF6

Endogenous ligands

ectodysplasin A2 (EDA, Q92838) [11]

Comment

Receptor for the EDA-A2 isoform of ectodysplasin encoded by the anhidrotic ectodermal dysplasia (EDA) gene.

ectodysplasin 1, anhidrotic receptor C Show summary »« Hide summary

Target Id

2325

Nomenclature

ectodysplasin 1, anhidrotic receptor

Previous and unofficial names

DL | ectodermal dysplasia receptor | ectodysplasin-A receptor | ED1R | ED5 | EDA3 | ectodysplasin A receptor

Genes

EDAR (Hs), Edar (Mm), Edar (Rn)

Ensembl ID

ENSG00000135960 (Hs), ENSMUSG00000003227 (Mm), ENSRNOG00000028598 (Rn)

UniProtKB AC

Q9UNE0 (Hs), Q9R187 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3

Endogenous ligands

ectodysplasin A1 (EDA, Q92838) [11]

Comment

Cell surface receptor for ectodysplasin A (a morphogen involved in the development of ectodermal tissues, including skin, hair, nails, teeth, and sweat glands).

Comments

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References

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1. Bremer E. (2013) Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy. ISRN Oncol, 2013: 371854. [PMID:23840967]

2. Brenner D, Blaser H, Mak TW. (2015) Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol, 15 (6): 362-74. [PMID:26008591]

3. Dhillon S. (2024) Aponermin: First Approval. Drugs, 84 (4): 459-466. [PMID:38441805]

4. Hanson GJ, Vuletich JL, Bedell LJ, Bono CP, Howard SC, Welpy JW, Woulfe SL, Zacheis ML. (1996) Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5. Bioorg Med Chem Lett, 6 (16): 1931–1936.

5. Jeon YH, Lee JY, Kim S. (2012) Chemical modulators working at pharmacological interface of target proteins. Bioorg Med Chem, 20 (6): 1893-901. [PMID:22227462]

6. Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM. (2006) Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J Neurosci, 26 (20): 5288-300. [PMID:16707781]

7. Sedger LM, McDermott MF. (2014) TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. Cytokine Growth Factor Rev, 25 (4): 453-72. [PMID:25169849]

8. Song Y, Margolles-Clark E, Bayer A, Buchwald P. (2014) Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction. Br J Pharmacol, 171 (21): 4955-69. [PMID:24930776]

9. Wang EC. (2012) On death receptor 3 and its ligands…. Immunology, 137 (1): 114-6. [PMID:22612445]

10. Webb GJ, Hirschfield GM, Lane PJ. (2016) OX40, OX40L and Autoimmunity: a Comprehensive Review. Clin Rev Allergy Immunol, 50 (3): 312-32. [PMID:26215166]

11. Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. (2000) Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science, 290 (5491): 523-7. [PMID:11039935]

12. Zhou T, Ichikawa K, Kimberley RP, Koopman WJ. (2001) An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof. Patent number: WO2001083560. Assignee: Uab Research Foundation. Priority date: 02/05/2000. Publication date: 08/11/2001.

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.