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Blood coagulation components C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Coagulation as a process is interpreted as a mechanism for reducing excessive blood loss through the generation of a gel-like clot local to the site of injury. The process involves the activation, adhesion (see Integrins), degranulation and aggregation of platelets, as well as proteins circulating in the plasma. The coagulation cascade involves multiple proteins being converted to more active forms from less active precursors (for example, prothrombin [Factor II] is converted to thrombin [Factor IIa]), typically through proteolysis (see Proteases). Listed here are the components of the coagulation cascade targeted by agents in current clinical usage or at an advanced level of development.

Enzymes

3192
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coagulation factor II, thrombin / prothrombin C Show summary » More detailed page go icon to follow link

coagulation factor III, tissue factor Show summary »


Target Id 3192
Nomenclature coagulation factor III, tissue factor
Previous and unofficial names CD142 | coagulation factor III | thromboplastin
Genes F3 (Hs), F3 (Mm), F3 (Rn)
Ensembl ID ENSG00000117525 (Hs), ENSMUSG00000028128 (Mm), ENSRNOG00000011800 (Rn)
UniProtKB AC P13726 (Hs), P20352 (Mm)
Antibodies
tisotumab vedotin (Binding) [1]
Comment Factor 3 is the main physiological trigger for blood coagulation in response to vascular damage. The F3/factor VIIa complex catalyses the proteolytic activation of coagulation factors IX and X.

coagulation factor V C Show summary » More detailed page go icon to follow link

coagulation factor VIII C Show summary » More detailed page go icon to follow link

coagulation factor X C Show summary » More detailed page go icon to follow link

coagulation factor XI Show summary » More detailed page go icon to follow link

antithrombin, antithrombin III (serpin family C member 1) C Show summary » More detailed page go icon to follow link

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.