Cd2+   

GtoPdb Ligand ID: 2440

Synonyms: cadmium ion
Compound class: Inorganic
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
DMT1
Zinc transporter 14 5
Zinc transporter 8 4,12
Solute carrier family 41 member 1 6
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Cav1.3 N/A Channel blocker Antagonist - - 2x10-4 16
Conc range: 2x10-4 M [16]
Voltage: -60.0 mV
TRPP1 Hs Channel blocker - - - 1x10-4 15
Conc range: 1x10-4 M [15]
Voltage: 0.0 mV
TRPA1 Hs Activator Activation 5.8 pEC50 - 1,13
pEC50 5.8 (EC50 1.4x10-6 M) [1,13]
Description: Sodium and calcium imaging
Conditions: CHO cells expressing human TRPA1 and mouse dorsal root ganglion neurons
TRPA1 Mm Activator Activation 5.7 pEC50 - 1,13
pEC50 5.7 (EC50 2.1x10-6 M) [1,13]
Cav2.1 Oc Channel blocker - 6.0 – 6.3 pIC50 -
pIC50 6.0 – 6.3
Voltage: -80.0 – -60.0 mV
Cav2.3 Hs Channel blocker Antagonist 6.1 pIC50 - 17
pIC50 6.1 [17]
Voltage: -90.0 mV
Cav1.2 Oc Channel blocker - 5.7 – 6.0 pIC50 - 7
pIC50 5.7 – 6.0 [7]
Voltage: -80.0 mV
Hv1 Hs Channel blocker - ~5.0 pIC50 -
pIC50 ~5.0 (IC50 ~1x10-5 M)
Cav1.1 Rn Channel blocker Antagonist 4.3 pIC50 - 2
pIC50 4.3 [2]
Voltage: -80.0 mV
ClC-4 Hs Channel blocker - 4.2 pIC50 - 14
pIC50 4.2 (IC50 6.8x10-5 M) [14]
Navi2.1 Hs Channel blocker - 3.8 pIC50 -
pIC50 3.8 (IC50 1.5x10-4 M)
TPC1 Hs Channel blocker Inhibition 3.7 pIC50 - 3
pIC50 3.7 (IC50 1.8x10-4 M) [3]
CatSper1 Mm Channel blocker Inhibition 3.7 pIC50 - 10
pIC50 3.7 (IC50 2x10-4 M) [10]
Description: Whole cell patch clamp
CatSper2 Mm Channel blocker Inhibition 3.7 pIC50 - 9
pIC50 3.7 (IC50 2x10-4 M) [9]
Description: Whole cell patch clamp.
CatSper3 Mm Channel blocker Antagonist 3.7 pIC50 - 10
pIC50 3.7 (IC50 2x10-4 M) [10]
Description: Whole cell patch clamp electrophysiology.
CatSper4 Mm Channel blocker Antagonist 3.7 pIC50 - 10
pIC50 3.7 (IC50 2x10-4 M) [10]
Description: Whole cell patch clamp electrophysiology.
TRPC6 Mm Channel blocker Antagonist 3.6 pIC50 - 8
pIC50 3.6 (IC50 2.53x10-4 M) [8]
Voltage: -60.0 mV
Nav1.7 Hs Channel blocker Pore blocker 3.0 pIC50 - 11
pIC50 3.0 [11]
Voltage: -100.0 mV
ASIC2 Hs Channel blocker - ~3.0 pIC50 -
pIC50 ~3.0 (IC50 ~1x10-3 M)
TRPV6 Hs Channel blocker - - - -
Kv12.1 Mm Gating inhibitor - - - - 18
[18]
Description: 1 mM Cd2+ slows activation 5-fold and shifts V0.5 for activation by +35 mV
Conditions: Heterologous expression in Xenopus oocytes
ClC-1 Hs Channel blocker - - - -
ClC-2 Hs Channel blocker - - - -
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference