G protein-coupled receptors
Download the list of all GPCR targets in CSV format 
| Calcitonin receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
adrenomedullin 2/intermedin {Sp: Human} amylin {Sp: Human} , amylin {Sp: Mouse, Rat} calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} |
CT receptor |
CALCR |
Calcr |
Calcr |
Calcitonin and amylin are the principal endogenous agonists. |
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat} amylin {Sp: Human} , amylin {Sp: Mouse, Rat} calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} |
AMY1 receptor | Amylin, α-CGRP, and β-CGRP are the most potent endogenous agonists | |||
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat} amylin {Sp: Human} , amylin {Sp: Mouse, Rat} calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} |
AMY2 receptor | Amylin is the most potent endogenous agonist | |||
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
adrenomedullin 2/intermedin {Sp: Human} amylin {Sp: Human} , amylin {Sp: Mouse, Rat} calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} |
AMY3 receptor | Amylin is the principal endogenous agonist | |||
| Calcitonin receptors | adrenomedullin, CGRP | calcitonin receptor-like receptor |
CALCRL |
Calcrl |
Calcrl |
Functional receptor is a dimer of 7TM and RAMP; ligand depends on RAMP |
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
,
adrenomedullin
{Sp: Mouse}
,
adrenomedullin
{Sp: Rat}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} α-CGRP-(8-37) (rat) |
CGRP receptor | α-CGRP and β-CGRP are the principal endogenous agonists | |||
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
,
adrenomedullin
{Sp: Mouse}
,
adrenomedullin
{Sp: Rat}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} |
AM1 receptor | Adrenomedullin and adrenomedullin 2/intermedin are the most likely physiological agonists. | |||
| Calcitonin receptors |
adrenomedullin
{Sp: Human}
,
adrenomedullin
{Sp: Mouse}
,
adrenomedullin
{Sp: Rat}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat} α-CGRP {Sp: Human} β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse} α-CGRP {Sp: Mouse, Rat} β-CGRP {Sp: Rat} α-CGRP-(8-37) (rat) |
AM2 receptor | Adrenomedullin and adrenomedullin 2/intermedin are the most potent endogenous agonists | |||
| Corticotropin-releasing factor receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Corticotropin-releasing factor receptors |
corticotrophin-releasing hormone
{Sp: Human, Mouse, Rat}
urocortin 2 {Sp: Human} urocortin 1 {Sp: Human} , urocortin 1 {Sp: Mouse, Rat} |
CRF1 receptor |
CRHR1 |
Crhr1 |
Crhr1 |
|
| Corticotropin-releasing factor receptors |
corticotrophin-releasing hormone
{Sp: Human, Mouse, Rat}
urocortin 1 {Sp: Human} urocortin 2 {Sp: Human} urocortin 3 {Sp: Human} urocortin 2 {Sp: Mouse} urocortin 1 {Sp: Mouse, Rat} urocortin 3 {Sp: Mouse, Rat} urocortin 2 {Sp: Rat} |
CRF2 receptor |
CRHR2 |
Crhr2 |
Crhr2 |
|
| Glucagon receptor family | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Glucagon receptor family |
GHRH
{Sp: Human}
,
GHRH
{Sp: Mouse}
,
GHRH
{Sp: Rat}
|
GHRH receptor |
GHRHR |
Ghrhr |
Ghrhr |
|
| Glucagon receptor family |
gastric inhibitory polypeptide
{Sp: Human}
,
gastric inhibitory polypeptide
{Sp: Mouse}
,
gastric inhibitory polypeptide
{Sp: Rat}
|
GIP receptor |
GIPR |
Gipr |
Gipr |
|
| Glucagon receptor family |
glucagon
{Sp: Human, Mouse, Rat}
glucagon-like peptide 1-(7-37) {Sp: Human, Mouse, Rat} glucagon-like peptide 1-(7-36) amide {Sp: Human, Mouse, Rat} |
GLP-1 receptor |
GLP1R |
Glp1r |
Glp1r |
|
| Glucagon receptor family |
glucagon-like peptide 2
{Sp: Human}
glucagon-like peptide 2-(3-33) {Sp: Human} glucagon-like peptide 2 {Sp: Mouse} glucagon-like peptide 2-(3-33) {Sp: Mouse} glucagon-like peptide 2-(2-33) {Sp: Rat} glucagon-like peptide 2 {Sp: Rat} glucagon-like peptide 2-(3-33) {Sp: Rat} |
GLP-2 receptor |
GLP2R |
Glp2r |
Glp2r |
|
| Glucagon receptor family |
glucagon
{Sp: Human, Mouse, Rat}
|
glucagon receptor |
GCGR |
Gcgr |
Gcgr |
|
| Glucagon receptor family |
secretin
{Sp: Human}
,
secretin
{Sp: Mouse}
,
secretin
{Sp: Rat}
VIP {Sp: Human, Mouse, Rat} |
secretin receptor |
SCTR |
Sctr |
Sctr |
|
| Parathyroid hormone receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Parathyroid hormone receptors |
PTH
{Sp: Human}
,
PTH
{Sp: Mouse}
,
PTH
{Sp: Rat}
PTHrP-(1-36) {Sp: Human} PTHrP {Sp: Human} TIP39 {Sp: Human, Bovine} |
PTH1 receptor |
PTH1R |
Pth1r |
Pth1r |
Other endogenous fragments of parathyroid hormone-related protein precursor are PTHrP-(107-139) (human)/PTHrP-(107-139) (mouse)/PTHrP-(107-139) (rat) and PTHrP-(38-94). |
| Parathyroid hormone receptors |
PTH
{Sp: Human}
,
PTH
{Sp: Mouse}
,
PTH
{Sp: Rat}
PTHrP-(1-36) {Sp: Human} PTHrP-(1-34) (human) TIP39 {Sp: Human, Bovine} , TIP39 {Sp: Mouse, Rat} |
PTH2 receptor |
PTH2R |
Pth2r |
Pth2r |
PTH is a weak partial agonist in rat. PTHrP has very low efficacy. Other endogenous fragments of parathyroid hormone-related protein precursor are PTHrP-(107-139) (human)/PTHrP-(107-139) (mouse)/PTHrP-(107-139) (rat) and PTHrP-(38-94). |
| VIP and PACAP receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| VIP and PACAP receptors |
PACAP-38
{Sp: Human, Mouse, Rat}
PACAP-27 {Sp: Human, Mouse, Rat, Sheep} PHI {Sp: Mouse, Rat} PHM {Sp: Human} PHV {Sp: Human} , PHV {Sp: Rat} VIP {Sp: Human, Mouse, Rat} |
PAC1 receptor |
ADCYAP1R1 |
Adcyap1r1 |
Adcyap1r1 |
PACAP-27 and PACAP-38 are the principal endogenous agonists |
| VIP and PACAP receptors |
GHRH
{Sp: Human}
,
GHRH
{Sp: Mouse}
,
GHRH
{Sp: Rat}
PACAP-38 {Sp: Human, Mouse, Rat} PACAP-27 {Sp: Human, Mouse, Rat, Sheep} PHI {Sp: Mouse, Rat} PHM {Sp: Human} PHV {Sp: Rat} secretin {Sp: Human} , secretin {Sp: Mouse} , secretin {Sp: Rat} VIP {Sp: Human, Mouse, Rat} |
VPAC1 receptor |
VIPR1 |
Vipr1 |
Vipr1 |
VIP, PACAP-27 and PACAP-38 are the principal endogenous agonists |
| VIP and PACAP receptors |
GHRH
{Sp: Human}
,
GHRH
{Sp: Mouse}
,
GHRH
{Sp: Rat}
PACAP-38 {Sp: Human, Mouse, Rat} PACAP-27 {Sp: Human, Mouse, Rat, Sheep} PHI {Sp: Mouse, Rat} PHV {Sp: Rat} secretin {Sp: Human} , secretin {Sp: Mouse} , secretin {Sp: Rat} VIP {Sp: Human, Mouse, Rat} |
VPAC2 receptor |
VIPR2 |
Vipr2 |
Vipr2 |
VIP, PACAP-38 and PACAP-27 are the principal endogenous agonists |
