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Synonyms: AZ-14117230 | compound 2 [PMID: 31786184] | EED PROTAC 1 [1]
Compound class:
Synthetic organic
Comment: AZ14117230 is a proteolysis-targeting chimera (PROTAC) molecule that targets the embryonic ectoderm development (EED) protein for degradation by promoting ternary complex formation with the VHL E3 ubiquitin ligase [1]. A second EED PROTAC (AZ14118579, compound 3) is also reported in the Hsu et al. article [1]. EED is a subunit of the PRC2 complex (alongside EZH2 and SUZ12) that promotes tumourigenesis by driving aberrant hypermethylation of H3K27.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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