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Synonyms: compound 29 [PMID: 37523716] | SMD3040
Compound class:
Synthetic organic
Comment: SMD-3040 is an experimental SMARCA2 PROTAC degrader [1]. It uses a SMARCA2/4 bromodomain-binding ligand (SMARCA2/4 ligand 3 [1]) to recruit the target protein to the VHL E3 ligase to initiate its proteasomal degradation. Targeting SMARCA2 in SMARCA4 deficient tumours induces synthetic lethality in preclinical tumour models.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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