Compound class:
Synthetic organic
Comment: KT-333 is a VHL-based STAT3 PROTAC degrader. STAT3 is a transcriptional regulator whose activity has been associated with the development of cancers, and to inflammatory and autoimmune diseases. The structure of the molecule presented here was obtained from Drug Hunter (April 2024). This chemical structure is closely related to STAT3 degrader I-241 in Kymera patent US11485750B1 which has additional specified stereo centers [1]. We await formal disclosure of KT-333's structure in peer-reviewed literature (May 2024).
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