Ca2+   Click here for help

GtoPdb Ligand ID: 707

Synonyms: calcium ion
Compound class: Inorganic
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Natural/Endogenous Targets
Target
5-HT3A
CaCC
CaS receptor
Cx23
Cx25
Cx26
Cx30
Cx30.2
Cx30.3
Cx31
Cx31.1
Cx31.9
Cx32
Cx36
Cx37
Cx40
Cx40.1
Cx43
Cx45
Cx46
Cx47
Cx50
Cx59
Cx62
IP3R1
IP3R2
IP3R3
Cofactor in Enzyme Reactions
Enzyme Reference
thyroid peroxidase
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CaS receptor Ligand is endogenous in the given species Mm Agonist Full agonist 2.5 pKd - 35
pKd 2.5 [35]
CaS receptor Ligand is endogenous in the given species Rn Agonist Full agonist 2.5 pKd - 36
pKd 2.5 [36]
CaS receptor Ligand is endogenous in the given species Hs Agonist Full agonist 2.4 pKd - 28
pKd 2.4 [28]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT3A Ligand is endogenous in the given species Hs Allosteric modulator Negative - - 1x10-4 - 1x10-2 3,27
Conc range: 1x10-4 - 1x10-2 M Decreased single channel conductance, increased channel activation rate, increased deactivation rate, increased desensitization rate, decrease in agonist apparent affinity. [3,27]
5-HT3A Ligand is endogenous in the given species Mm Allosteric modulator Negative - - 1x10-4 - 1x10-2 9,16,29
Conc range: 1x10-4 - 1x10-2 M Decreased single channel conductance, increased channel activation rate, increased deactivation rate, increased desensitization rate, decrease in agonist apparent affinity. [9,16,29]
TRPP2 Hs Activator (Intracellular Ca2+) Agonist - - 5x10-3 5
Conc range: 5x10-3 M [5]
Voltage: -150.0 – 100.0 mV
Conc range: 5x10-3 M [5]
Voltage: -60.0 – -50.0 mV
RyR2 Ligand is endogenous in the given species Hs Antagonist (cytosolic Ca2+) Antagonist - - > 1x10-3
Conc range: > 1x10-3 M
RyR3 Ligand is endogenous in the given species Hs Antagonist (cytosolic Ca2+) Antagonist - - > 1x10-3
Conc range: > 1x10-3 M
IP3R1 Ligand is endogenous in the given species Hs Activator (cytosolic Ca2+) - - - < 7.5x10-4
Conc range: < 7.5x10-4 M
RyR1 Ligand is endogenous in the given species Hs Antagonist (cytosolic Ca2+) Antagonist - - > 1x10-4
Conc range: > 1x10-4 M
KNa1.1 Ligand is endogenous in the given species Rn Gating inhibitor Antagonist - - 0x100 - 3x10-6 20
Conc range: 0x100 - 3x10-6 M [20]
KCa3.1 Hs Activator Agonist 6.1 – 7.0 pEC50 - 10,17,21,26,37
pEC50 6.1 – 7.0 [10,17,21,26,37]
Voltage: -120.0 – 60.0 mV
KCa2.1 Ligand is endogenous in the given species Hs Activator Agonist 6.2 – 6.5 pEC50 - 22,43
pEC50 6.2 – 6.5 (EC50 6x10-7 – 3x10-7 M) [22,43]
Voltage: -80.0 mV
KCa2.2 Ligand is endogenous in the given species Hs Activator Agonist 6.2 – 6.5 pEC50 - 7,34,43
pEC50 6.2 – 6.5 [7,34,43]
KCa2.2 Ligand is endogenous in the given species Rn Activator Agonist 6.1 – 6.4 pEC50 - 13,22
pEC50 6.1 – 6.4 [13,22]
KCa2.3 Hs Activator Agonist 6.0 – 6.5 pEC50 - 15,42-43
pEC50 6.0 – 6.5 [15,42-43]
KCa2.3 Ligand is endogenous in the given species Rn Activator Agonist 6.2 pEC50 - 1
pEC50 6.2 [1]
TRPC5 Ligand is endogenous in the given species Hs Activator (intracellular Ca2+) - 6.2 pEC50 -
pEC50 6.2 (EC50 6.35x10-7 M) at negative potentials
TRPC5 Mm Activator Activation 6.0 pEC50 - 2,11
pEC50 6.0 Internal calcium [2,11]
TRPP1 Hs Activator (Intracellular Ca2+) - 6.0 pEC50 1x10-7 - 1x10-3 23
pEC50 6.0 Conc range: 1x10-7 - 1x10-3 M [23]
Voltage: -5.0 mV
TRPM5 Ligand is endogenous in the given species Mm Activator (intracellular Ca2+) Agonist 4.5 – 6.2 pEC50 - 14,25,41
pEC50 4.5 – 6.2 (EC50 3x10-5 – 7x10-7 M) [14,25,41]
Voltage: -80.0 – 80.0 mV
TRPM4 Ligand is endogenous in the given species Hs Activator (intracellular Ca2+) Agonist 3.9 – 6.3 pEC50 - 30-32,38
pEC50 3.9 – 6.3 (EC50 1.4x10-4 – 5x10-7 M) [30-32,38]
Voltage: -100.0 – 100.0 mV
KNa1.1 Mm Gating inhibitor Antagonist 6.5 pIC50 - 33
pIC50 6.5 [33]
TRPM6 Ligand is endogenous in the given species Hs Channel blocker - 5.3 – 5.3 pIC50 -
pIC50 5.3 – 5.3 (IC50 5.4x10-6 – 4.8x10-6 M) inward current mediated by monovalent cations is blocked
ZAC Hs Antagonist Antagonist 2.0 pIC50 - 40
pIC50 2.0 [40]
TRPC2 Ligand is endogenous in the given species N/A Activator (Intracellular Ca2+) - - - -
TRPM2 Ligand is endogenous in the given species Hs Activator (intracellular Ca2+) - - - -
perhaps via calmodulin
CaCC Ligand is endogenous in the given species Hs Activator (intracellular Ca2+) - - - -
Cx23 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx25 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx26 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx30 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx30.2 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx30.3 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx31 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx31.1 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx31.9 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx32 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx36 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx37 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx40 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx40.1 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx43 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx45 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx46 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx47 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx50 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx59 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
Cx62 Ligand is endogenous in the given species Hs Inhibitor (extracellular Ca2+) - - - -
blocked by raising external Ca2+
IP3R2 Ligand is endogenous in the given species Hs Activator (cytosolic Ca2+) - - - -
nM range
IP3R3 Ligand is endogenous in the given species Hs Activator (cytosolic Ca2+) - - - -
nM range
RyR1 Ligand is endogenous in the given species Hs Activator (luminal Ca2+) - - - -
endogenous
endogenous; μM range
RyR2 Ligand is endogenous in the given species Hs Activator (luminal Ca2+) - - - -
endogenous
endogenous; μM range
RyR3 Ligand is endogenous in the given species Hs Activator (cytosolic Ca2+) - - - -
endogenous; μM range
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields