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Plasmodium falciparum

Species ID:103
Name:Plasmodium falciparum
Associated with:34 targets
123 ligands
Description
P. falciparum (Pf) is one of five protozoan parasite species of the genus Plasmodium that cause malaria in humans. Pf is responsible for the majority of malaria related deaths and is the most prevalent species in sub-Saharan Africa.

Interactions

Interactions
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Target Ligand Sp. Action Value Parameter Reference
Plasmodium falciparum dihydroorotate dehydrogenase DSM265 PfNF54 - 7.5 pIC50 75
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [75]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM265 Pf Inhibition 7.5 pIC50 46
pIC50 7.5 (IC50 3x10-8 M) [46]
Description: Steady-state kinetic analysis.
Plasmodium falciparum dihydroorotate dehydrogenase DSM421 Pf3D7 - 7.4 – 7.8 pEC50 76
pEC50 7.8 (EC50 1.4x10-8 M) SYBR Green incorporation (72h assay) [76]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pEC50 7.4 (EC50 4.3x10-8 M) SYBR Green incorporation (48h assay) [76]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM421 Pf Inhibition 7.3 pIC50 76
pIC50 7.3 (IC50 5.3x10-8 M) [76]
Description: Steady-state kinetic analysis of recombinant enzyme inhibition.
Plasmodium falciparum dihydroorotate dehydrogenase DSM502 Pf3D7 - 7.8 pEC50 46
pEC50 7.8 (EC50 1.4x10-8 M) SYBR Green I [46]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM502 Pf Inhibition 7.7 pIC50 46
pIC50 7.7 (IC50 2x10-8 M) [46]
Description: Steady-state kinetic analysis.
Plasmodium falciparum dihydroorotate dehydrogenase DSM502 PfDd2 - 7.8 pEC50 46
pEC50 7.8 (EC50 1.6x10-8 M) SYBR Green I [46]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase BRD9185 Pf Inhibition 7.9 pIC50 56
pIC50 7.9 (IC50 1.2x10-8 M) [56]
Plasmodium falciparum dihydroorotate dehydrogenase BRD9185 PfDd2 - 7.8 pEC50 56
pEC50 7.8 (EC50 1.6x10-8 M) SYBR Green I assay [56]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM705 Pf3D7 - 7.9 pEC50 70
pEC50 7.9 (EC50 1.2x10-8 M) SYBR Green I assay (72h) [70]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM705 Pf Inhibition 7.0 pIC50 70
pIC50 7.0 (IC50 9.5x10-8 M) [70]
Description: Steady-state kinetic analysis.
Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit BRD3444 Pf3D7 - 6.2 pEC50 43
pEC50 6.2 (EC50 6.63x10-7 M) [43]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (IV–V) gametocyte assay
Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit BRD3444 Pf Inhibition 7.3 pIC50 43
pIC50 7.3 (IC50 4.6x10-8 M) [43]
Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit BRD3444 PfDd2 - 8.1 pEC50 43
pEC50 8.1 (EC50 9x10-9 M) SYBR Green I assay [43]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit BRD7929 Pf3D7 - 6.8 pEC50 43
pEC50 6.8 (EC50 1.6x10-7 M) [43]
Description: Parasite late stage (IV–V) gametocyte assay
Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit BRD7929 Pf Inhibition 7.6 pIC50 43
pIC50 7.6 (IC50 2.3x10-8 M) [43]
Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit BRD7929 PfDd2 - 8.1 pEC50 43
pEC50 8.1 (EC50 9x10-9 M) SYBR Green I assay [43]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase compound 34c [PMID: 24641010] Pf3D7 - 6.5 pEC50 80
pEC50 6.5 (EC50 3.02x10-7 M) [3H]-hypoxanthine incorporation [80]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase compound 34c [PMID: 24641010] Pf3D7 Inhibition 8.1 pKi 80
pKi 8.1 (Ki 8x10-9 M) [80]
Description: Enzyme inhibition assay
Plasmodium falciparum N-myristoyltransferase compound 34c [PMID: 24641010] PfNF54 - 6.6 pEC50 80
pEC50 6.6 (EC50 2.32x10-7 M) [3H]-hypoxanthine incorporation [80]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase compound 34c [PMID: 24641010] PfK1 - 6.5 pEC50 80
pEC50 6.5 (EC50 3.39x10-7 M) [3H]-hypoxanthine incorporation [80]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase compound 34c [PMID: 24641010] PfDd2 - 6.0 pEC50 80
pEC50 6.0 (EC50 9.16x10-7 M) [3H]-hypoxanthine incorporation [80]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase DDD85646 Pf - 6.6 pEC50 105
pEC50 6.6 (EC50 2.5x10-7 M) SYBR Green assay [105]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase IMP-1002 Pf3D7 - 7.5 pEC50 89
pEC50 7.5 (EC50 3.4x10-8 M) SYBR Green incorporation [89]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-myristoyltransferase IMP-1002 PfDd2 - 7.7 pEC50 89
pEC50 7.7 (EC50 2.04x10-8 M) SYBR Green incorporation [89]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin Pf3D7 - 9.1 pIC50 84
pIC50 9.1 (IC50 7x10-10 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfNF54 - - - 97
Giemsa-stained blood film counts: dose-dependent, inhibition of stage V gametocyte development [97]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (III–V) gametocyte assay
Oocyst count: significantly reduced count observed with the addition of cipargamin when compared to control feeds [97]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Giemsa-stained blood film counts: dose-dependent, significant inhibition of stage II gametocyte development [97]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite early stage (I–II) gametocyte assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfNF54 - 9.3 pIC50 84
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfV1/S - 8.9 pIC50 84
pIC50 8.9 (IC50 1.4x10-9 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfK1 - 9.2 pIC50 84
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfD6 - 9.0 pIC50 84
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin Pf7G8 - 8.9 pIC50 84
pIC50 8.9 (IC50 1.2x10-9 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfW2 - 9.1 pIC50 84
pIC50 9.1 (IC50 9x10-10 M) [3H]-hypoxanthine incorporation assay [84]
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfTM90C2A - 9.3 pIC50 84
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation assay [84]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase cipargamin PfTM91C235 - 9.1 pIC50 84
pIC50 9.1 (IC50 9x10-10 M) [3H]-hypoxanthine incorporation assay [84]
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase (+)-SJ733 Pf3D7 - 7.5 pEC50 39
pEC50 7.5 (EC50 3x10-8 M) SYBR Green I assay [39]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase (+)-SJ733 PfV1/S - 7.2 pEC50 39
pEC50 7.2 (EC50 6x10-8 M) SYBR Green I assay [39]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase (+)-SJ733 PfK1 - 7.4 pEC50 39
pEC50 7.4 (EC50 4x10-8 M) SYBR Green I assay [39]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase (+)-SJ733 PfDd2 - 7.7 pEC50 39
pEC50 7.7 (EC50 2x10-8 M) SYBR Green I assay [39]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 Pf3D7 - 7.7 pEC50 96
pEC50 7.7 (EC50 1.8x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfNF54 - 7.1 – 7.4 pEC50 96
pEC50 7.4 (EC50 3.9x10-8 M) inhibition of gamete formation from mature Stage V male gametocytes [96]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite dual gamete formation assay (DGFA)
pEC50 7.1 (EC50 7.4x10-8 M) inhibition of gamete formation from mature Stage V female gametocytes [96]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite dual gamete formation assay (DGFA)
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfV1/S - 7.4 pEC50 96
pEC50 7.4 (EC50 3.8x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfTM90C2A - 7.8 pEC50 96
pEC50 7.8 (EC50 1.4x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfDd2 - 7.7 pEC50 96
pEC50 7.7 (EC50 2.2x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfHB3 - 7.5 pEC50 96
pEC50 7.5 (EC50 3.2x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfFCR3 - 7.7 pEC50 96
pEC50 7.7 (EC50 1.9x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase PA21A092 PfTM90C2B - 7.9 pEC50 96
pEC50 7.9 (EC50 1.3x10-8 M) [3H]-hypoxanthine incorporation [96]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase GSK030 Pf - 7.3 pIC50 17
pIC50 7.3 (IC50 5.2x10-8 M) [3H]-hypoxanthine incorporation [17]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase MMV1803022 Pf3D7 - 6.3 pIC50 94
pIC50 6.3 (IC50 4.6x10-7 M) SYBR Green I assay [94]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase MMV897698 Pf3D7 - 6.4 pIC50 95
pIC50 6.4 (IC50 3.8x10-7 M) SYBR Green I assay [95]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase compound 1a [WO2021204952A1] Pf3D7 - 7.7 pEC50 25
pEC50 7.7 (EC50 1.9x10-8 M) SYBR Green assay [25]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase compound 1a [WO2021204952A1] PfNF54 - - - 25
Relative oocyst intensities, determined using transgenic reporter strain P. falciparum NF54-HGL, show that compound 1a has transmission-blocking potential [25]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Plasmodium falciparum phosphatidylinositol 4-kinase beta MMV048 PfNF54 - 6.6 – 7.6 pIC50 71
pIC50 7.6 (IC50 2.8x10-8 M) [3H]-hypoxanthine incorporation assay [71]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 6.8 (IC50 1.4x10-7 M) Parasite late stage (IV-V) gametocyte assay using luciferase reporter line [71]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
pIC50 6.7 (IC50 2.14x10-7 M) Parasite early stage (I-III) gametocyte assay using luciferase reporter line [71]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
pIC50 6.6 (IC50 2.85x10-7 M) Parasite late stage (IV-V) gametocyte assay: parasitic lactate dehydrogenase (pLDH) assay [71]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta MMV048 Pf - 6.9 pIC50 71
pIC50 6.9 (IC50 1.11x10-7 M) Indirect SMFA [71]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Plasmodium falciparum phosphatidylinositol 4-kinase beta MMV048 Pf Binding 6.5 – 7.0 pKd 71
pKd 7.0 (Kd 1x10-7 M) [71]
pKd 6.5 (Kd 3x10-7 M) [71]
Plasmodium falciparum phosphatidylinositol 4-kinase beta compound 55 [PMID: 29889526] PfNF54 - 7.2 pIC50 42
pIC50 7.2 (IC50 6.3x10-8 M) Parasite lactate dehydrogenase (pLDH ) assay [42]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta compound 55 [PMID: 29889526] PfK1 - 7.0 pIC50 42
pIC50 7.0 (IC50 1.02x10-7 M) Parasite lactate dehydrogenase (pLDH ) assay [42]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta MMV024101 PfNF54 - 6.3 pIC50 42
pIC50 6.3 (IC50 5.43x10-7 M) Parasite lactate dehydrogenase (pLDH ) assay [42]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 PfNF54 - 8.3 pIC50 6
pIC50 8.3 (IC50 5.4x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 PfV1/S - 8.4 pIC50 6
pIC50 8.4 (IC50 4.2x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 Pf - 6.9 – 7.2 pIC50 6
pIC50 7.2 (IC50 6.6x10-8 M) Parasite late stage (IV-V) gametocyte assay using luciferase reporter line [6]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
pIC50 7.1 (IC50 8x10-8 M) Reports on the functional viability of male and female mature stage V gametocytes [6]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite dual gamete formation assay (DGFA)
pIC50 7.0 (IC50 9.6x10-8 M) [6]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
pIC50 6.9 (IC50 1.34x10-7 M) Parasite early stage (I-III) gametocyte assay using luciferase reporter line [6]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 PfK1 - 8.3 pIC50 6
pIC50 8.3 (IC50 4.7x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 PfD6 - 8.3 pIC50 6
pIC50 8.3 (IC50 5.2x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 Pf7G8 - 8.4 pIC50 6
pIC50 8.4 (IC50 4.1x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 PfDd2 - 8.2 pIC50 6
pIC50 8.2 (IC50 5.7x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 PfHB3 - 8.4 pIC50 6
pIC50 8.4 (IC50 3.7x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta CHMFL-PI4K-127 Pf3D7 - 7.6 pEC50 53
pEC50 7.6 (EC50 2.51x10-8 M) SYBR Green I assay [53]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta CHMFL-PI4K-127 Pf Inhibition 9.1 pIC50 53
pIC50 9.1 (IC50 9x10-10 M) [53]
Plasmodium falciparum phosphatidylinositol 4-kinase beta CHMFL-PI4K-127 PfDd2 - 7.5 pEC50 53
pEC50 7.5 (EC50 3.03x10-8 M) SYBR Green I assay [53]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta NCATS-SM3710 PfNF54 - 9.4 pEC50 47
pEC50 9.4 (EC50 3.8x10-10 M) Viability measured using MitoProbe DiIC1(5) staining and flow cytometry [47]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta NCATS-SM3710 Pf - 8.2 pEC50 47
pEC50 8.2 (EC50 5.77x10-9 M) Viability measured using MitoProbe DiIC1(5) staining and flow cytometry [47]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (IV–V) gametocyte assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta NCATS-SM3710 Pf Inhibition 8.7 pIC50 47
pIC50 8.7 (IC50 2x10-9 M) [47]
Plasmodium falciparum phosphatidylinositol 4-kinase beta KDU691 PfNF54 - 6.7 pIC50 57
pIC50 6.7 (IC50 2.2x10-7 M) Parasite lactate dehydrogenase (pLDH) assay [57]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (III–V) gametocyte assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta KDU691 Pf - 7.5 pIC50 57
pIC50 7.5 (IC50 2.99x10-8 M) SYBR Green assay [57]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum elongation factor 2 M5717 Pf3D7 - 9.0 pEC50 4
pEC50 9.0 (EC50 1x10-9 M) [3H]-hypoxanthine incorporation assay [4]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum elongation factor 2 M5717 PfNF54 - 8.0 – 8.9 pEC50 4
pEC50 8.9 (EC50 1.2x10-9 M) Female gamete formation [4]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite gamete formation assay
pEC50 8.7 (EC50 1.8x10-9 M) Indirect SMFA [4]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
pEC50 8.7 (EC50 1.8x10-9 M) Male gamete formation [4]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite gamete formation assay
pEC50 8.0 (EC50 1x10-8 M) Direct SMFA [4]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase fosmidomycin PfDd2 - 6.5 pIC50 40
pIC50 6.5 (IC50 2.9x10-7 M) [3H]-hypoxanthine incorporation assay [40]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase fosmidomycin PfHB3 - 6.5 pIC50 40
pIC50 6.5 (IC50 3.5x10-7 M) [3H]-hypoxanthine incorporation assay [40]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase fosmidomycin PfA2 - 6.4 pIC50 40
pIC50 6.4 (IC50 3.7x10-7 M) [3H]-hypoxanthine incorporation assay [40]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfNF54 - 7.8 pIC50 16
pIC50 7.8 (IC50 1.7x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfV1/S - <4.0 – 5.0 pIC50 16,110
pIC50 <5.0 (IC50 >1x10-5 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 <4.0 (IC50 >1x10-4 M) [3H]-hypoxanthine incorporation assay using quadruple mutant P. falciparum (V1/S) [110]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfK1 - <5.0 pIC50 16
pIC50 <5.0 (IC50 >1x10-5 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfD6 - 8.3 pIC50 16
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine Pf7G8 - 5.2 pIC50 16
pIC50 5.2 (IC50 6.689x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfW2 - <5.0 pIC50 16
pIC50 <5.0 (IC50 >1x10-5 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfTM90C2A - 5.1 pIC50 16
pIC50 5.1 (IC50 8.231x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfTM4 - 7.2 pIC50 110
pIC50 7.2 (IC50 5.8x10-8 M) [3H]-hypoxanthine incorporation assay using wild-type P. falciparum (TM4) [110]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase P218 PfNF54 - 8.4 pIC50 77
pIC50 8.4 (IC50 4x10-9 M) Induction of male gamete activation (exflagellation) following 48 hour exposure of mature gametocytes to P218 [77]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite exflagellation assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase P218 PfV1/S - 7.3 pIC50 110
pIC50 7.3 (IC50 5.6x10-8 M) [3H]-hypoxanthine incorporation [110]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase P218 Pf - >7.9 pEC50 83
pEC50 >7.9 (EC50 <1.2x10-8 M) Primary human hepatocyte assay to assess inhibition of hepatic schizonts (prophylactic activity) [83]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase P218 PfTM4 - 8.3 pIC50 110
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [110]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfNF54 - 8.4 pIC50 16
pIC50 8.4 (IC50 4.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfV1/S - <5.0 pIC50 16
pIC50 <5.0 (IC50 >1x10-5 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfK1 - 6.3 pIC50 16
pIC50 6.3 (IC50 4.45x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfD6 - 8.8 pIC50 16
pIC50 8.8 (IC50 1.7x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil Pf7G8 - 6.4 pIC50 16
pIC50 6.4 (IC50 3.657x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfW2 - 6.0 pIC50 16
pIC50 6.0 (IC50 1.002x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfTM90C2A - 5.4 pIC50 16
pIC50 5.4 (IC50 4.262x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cGMP-dependent protein kinase ML10 Pf3D7 - 8.7 pEC50 2
pEC50 8.7 (EC50 2.1x10-9 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cGMP-dependent protein kinase ML10 Pf3D7 Inhibition 9.8 pIC50 2
pIC50 9.8 (IC50 1.6x10-10 M) [2]
Description: microfluidic mobility shift assay
Plasmodium falciparum cGMP-dependent protein kinase MMV030084 Pf3D7 - 7.0 pIC50 98
pIC50 7.0 (IC50 1.09x10-7 M) 72 hour growth inhibition assay [98]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cGMP-dependent protein kinase MMV030084 PfNF54 - 6.8 pIC50 98
pIC50 6.8 (IC50 1.41x10-7 M) Dual Gamete Formation Assay (DGFA): male gamete exflagellation was inhibited in the presence of MMV030084, but not when the compound was washed out prior to gamete formation. Activity against female gametes was not clearly identified [98]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite exflagellation assay
Plasmodium falciparum cGMP-dependent protein kinase MMV030084 Pf Inhibition 9.4 pIC50 98
pIC50 9.4 (IC50 4x10-10 M) [98]
Description: Kinase inhibition assay using recombinant PfPKG
Plasmodium falciparum cGMP-dependent protein kinase MMV030084 PfDd2 - 6.9 pIC50 98
pIC50 6.9 (IC50 1.2x10-7 M) 72 hour growth inhibition assay [98]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase halofuginone Pf3D7 - 9.1 pEC50 27
pEC50 9.1 (EC50 8.6x10-10 M) SYBR Green assay [27]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase halofuginone PfDd2 - 9.1 pEC50 27
pEC50 9.1 (EC50 8.1x10-10 M) SYBR Green assay [27]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase compound 1 [PMID: 33929818] Pf3D7 - 8.0 pIC50 67
pIC50 8.0 (IC50 1x10-8 M) DAPI incorporation assay (72h) [67]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase compound 1 [PMID: 33929818] PfNF54 - 7.7 pIC50 67
pIC50 7.7 (IC50 1.8x10-8 M) [3H]-hypoxanthine incorporation assay (72h) [67]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase compound 1 [PMID: 33929818] PfK1 - 7.7 pIC50 67
pIC50 7.7 (IC50 2x10-8 M) [3H]-hypoxanthine incorporation assay (72h) [67]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase compound 1 [PMID: 33929818] Pf7G8 - 7.7 pIC50 67
pIC50 7.7 (IC50 1.8x10-8 M) [3H]-hypoxanthine incorporation assay (72h) [67]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase compound 1 [PMID: 33929818] PfDd2 - 7.6 pIC50 67
pIC50 7.6 (IC50 2.4x10-8 M) [3H]-hypoxanthine incorporation assay (72h) [67]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum prolyl-tRNA synthetase compound 1 [PMID: 33929818] PfTM90C2B - 7.8 pIC50 67
pIC50 7.8 (IC50 1.7x10-8 M) [3H]-hypoxanthine incorporation assay (72h) [67]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum threonyl-tRNA synthetase borrelidin Pf3D7 - 8.9 – 9.0 pIC50 63
pIC50 9.0 (IC50 9.7x10-10 M) Parasite lactate dehydrogenase (pLDH ) assay following 96 hours in culture [63]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 8.9 (IC50 1.24x10-9 M) Parasite lactate dehydrogenase (pLDH ) assay following 48 hours in culture [63]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum threonyl-tRNA synthetase borrelidin PfK1 - 8.7 pIC50 69
pIC50 8.7 (IC50 1.9x10-9 M) Parasite lactate dehydrogenase (pLDH ) assay. [69]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum threonyl-tRNA synthetase borrelidin PfFCR3 - 8.7 pIC50 69
pIC50 8.7 (IC50 1.8x10-9 M) Parasite lactate dehydrogenase (pLDH ) assay [69]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum lysyl-tRNA synthetase cladosporin Pf3D7 - 7.3 pIC50 29
pIC50 7.3 (IC50 4.54x10-8 M) SYBR Green assay [29]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum lysyl-tRNA synthetase cladosporin PfNF54 - 7.1 pIC50 29
pIC50 7.1 (IC50 8.79x10-8 M) SYBR Green assay [29]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum lysyl-tRNA synthetase cladosporin PfK1 - 7.1 pIC50 29
pIC50 7.1 (IC50 8.01x10-8 M) SYBR Green assay [29]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum lysyl-tRNA synthetase cladosporin PfD6 - 7.1 pIC50 29
pIC50 7.1 (IC50 7.21x10-8 M) SYBR Green assay [29]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum lysyl-tRNA synthetase compound 5 [PMID: 30894487] Pf3D7 - 6.6 pEC50 3
pEC50 6.6 (EC50 2.7x10-7 M) SYBRgreen I [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum lysyl-tRNA synthetase compound 5 [PMID: 30894487] PfNF54 - <5.0 – 6.4 pEC50 3
pEC50 6.4 (EC50 3.9x10-7 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pEC50 <6.0 (EC50 >1x10-6 M) [3]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite gamete formation assay
pEC50 5.0 (EC50 9.9x10-6 M) Saponin-lysis Sexual Stage Assay (SaLSSA) [3]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite stage V gametocyte assay
Plasmodium falciparum lysyl-tRNA synthetase compound 5 [PMID: 30894487] PfK1 - 6.3 pEC50 3
pEC50 6.3 (EC50 5.1x10-7 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MMV008138 Pf Inhibition 8.1 pIC50 106
pIC50 8.1 (IC50 7x10-9 M) [106]
Description: Enzymatic activity measured using a pyrophosphate release assay
Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MMV008138 PfW2 - 7.0 pEC50 106
pEC50 7.0 (EC50 1.1x10-7 M) [106]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MMV008138 PfDd2 - 6.6 pIC50 108
pIC50 6.6 (IC50 2.5x10-7 M) SYBR green assay [108]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine Pf3D7 - 7.1 pIC50 102
pIC50 7.1 (IC50 7.3x10-8 M) [3H]-hypoxanthine incorporation [102]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine PfK1 - 6.7 pIC50 102
pIC50 6.7 (IC50 2.23x10-7 M) [3H]-hypoxanthine incorporation [102]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine PfDd2 - 5.4 pIC50 102
pIC50 5.4 (IC50 3.97x10-6 M) [3H]-hypoxanthine incorporation [102]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine PfHB3 - 8.4 pIC50 102
pIC50 8.4 (IC50 4x10-9 M) [3H]-hypoxanthine incorporation [102]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase dapsone Pf Inhibition 5.2 pKi 111
pKi 5.2 (Ki 6x10-6 M) [111]
Description: Enzyme inhibition assay.
Plasmodium falciparum hexose transporter TCMDC-125163 Pf3D7 - 5.8 pEC50 68
pEC50 5.8 (EC50 1.4x10-6 M) SYBR Green I assay [68]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hexose transporter TCMDC-125163 PfK1 - 6.0 pEC50 68
pEC50 6.0 (EC50 9.7x10-7 M) SYBR Green I assay [68]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hexose transporter HTI-1 Pf3D7 - 6.4 pEC50 38
pEC50 6.4 (EC50 3.77x10-7 M) SYBR Green I assay [38]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hexose transporter HTI-1 PfDd2 - 6.4 pEC50 38
pEC50 6.4 (EC50 3.98x10-7 M) SYBR Green I assay [38]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum plasmepsin X compound 49c [PMID: 29074775] PfNF54 - 6.3 – 9.2 pIC50 10
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation following 72 h incubation [10]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 <6.3 (IC50 >5x10-7 M) [3H]-hypoxanthine incorporation following 24 h incubation [10]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum plasmepsin X WM382 Pf3D7 - 9.2 pEC50 23
pEC50 9.2 (EC50 6x10-10 M) Results are for R-WM382 [23]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum plasmepsin X WM382 Pf - - - 23
Oocyst count: potent inhibition of oocyst development [23]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Plasmodium falciparum plasmepsin X WM382 Pf Inhibition 10.5 pKi 23
pKi 10.5 (Ki 3.5x10-11 M) [23]
Description: Peptide cleavage assay using recombinant PMX
Plasmodium falciparum plasmepsin X WM382 PfK1 - 9.2 pEC50 23
pEC50 9.2 (EC50 6.5x10-10 M) [23]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum plasmepsin X WM382 PfDd2 - 9.6 pEC50 23
pEC50 9.6 (EC50 2.6x10-10 M) [23]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum plasmepsin X compound 14a [WO2021155612A1] Pf - 9.7 pEC50 14
pEC50 9.7 (EC50 2x10-10 M) Parasite lactate dehydrogenase (pLDH ) assay following 72 hours in culture [14]
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 panobinostat Pf3D7 - 6.0 – 8.0 pIC50 22,92
pIC50 8.0 (IC50 1x10-8 M) [3H]-hypoxanthine incorporation [22]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 6.0 (IC50 9.35x10-7 M) AlamarBlue viability assay [92]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum histone deacetylase 1 panobinostat PfDd2 - 6.8 – 7.5 pIC50 22,92
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [22]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 6.8 (IC50 1.48x10-7 M) AlamarBlue viability assay [92]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum histone deacetylase 1 panobinostat PfHB3 - 6.9 pIC50 92
pIC50 6.9 (IC50 1.18x10-7 M) AlamarBlue viability assay [92]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum histone deacetylase 1 quisinostat Pf3D7 - 8.3 pEC50 33
pEC50 8.3 (EC50 5.2x10-9 M) SYBR Green I assay (72 hours) [33]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 quisinostat PfDd2 - 8.1 pEC50 33
pEC50 8.1 (EC50 7.1x10-9 M) SYBR Green I assay (72 hours) [33]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 compound 1u [PMID: 30245402] Pf3D7 - 8.4 pIC50 18
pIC50 8.4 (IC50 4x10-9 M) [3H]-hypoxanthine incorporation [18]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 compound 1u [PMID: 30245402] PfDd2 - 9.0 pIC50 18
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation [18]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 compound 2h [PMID: 30664827] Pf3D7 - 8.3 pIC50 55
pIC50 8.3 (IC50 5.2x10-9 M) [3H]-hypoxanthine incorporation [55]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 FNDR-20123 Pf3D7 - 7.4 pIC50 78
pIC50 7.4 (IC50 4.1x10-8 M) SYBR Green assay [78]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 FNDR-20123 PfNF54 - 7.6 pIC50 78
pIC50 7.6 (IC50 2.527x10-8 M) [78]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 FNDR-20123 Pf - 6.7 pIC50 78
pIC50 6.7 (IC50 1.9x10-7 M) Activity against male gametocytes. IC50 values of 190 nM for male and  > 5 µM for female gametocytes [78]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite dual gamete formation assay (DGFA)
Plasmodium falciparum histone deacetylase 1 FNDR-20123 PfK1 - 7.7 pIC50 78
pIC50 7.7 (IC50 1.905x10-8 M) [78]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 FNDR-20123 Pf7G8 - 7.8 pIC50 78
pIC50 7.8 (IC50 1.436x10-8 M) [78]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 FNDR-20123 PfDd2 - 7.8 pIC50 78
pIC50 7.8 (IC50 1.75x10-8 M) [78]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 FNDR-20123 PfTM90C2B - 7.9 pIC50 78
pIC50 7.9 (IC50 1.326x10-8 M) [78]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 JX21108 Pf3D7 - 8.4 pEC50 33
pEC50 8.4 (EC50 3.6x10-9 M) SYBR Green I assay (72 hours) [33]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 JX21108 PfNF54 - 7.4 – 8.2 pEC50 33
pEC50 8.2 (EC50 5.9x10-9 M) Parasite late stage (IV) gametocyte assay using luciferase reporter line [33]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
pEC50 7.4 (EC50 3.88x10-8 M) Parasite early stage (II) gametocyte assay using luciferase reporter line [33]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum histone deacetylase 1 JX21108 PfDd2 - 8.4 pEC50 33
pEC50 8.4 (EC50 4x10-9 M) SYBR Green I assay (72 hours) [33]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 JX35 Pf3D7 - 8.9 pIC50 101
pIC50 8.9 (IC50 1.26x10-9 M) SYBR Green I assay (72h) [101]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone deacetylase 1 JX35 PfNF54 - 7.8 – 7.9 pIC50 101
pIC50 7.9 (IC50 1.242x10-8 M) [101]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (V) gametocyte assay
pIC50 7.8 (IC50 1.583x10-8 M) [101]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite early stage (II) gametocyte assay
Plasmodium falciparum histone deacetylase 1 JX35 PfDd2 - 8.8 pIC50 101
pIC50 8.8 (IC50 1.61x10-9 M) SYBR Green I assay (72h) [101]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum GPI-anchored wall transfer protein 1 compound VII [WO2021149692A1] Pf3D7 - 7.5 pIC50 31
pIC50 7.5 (IC50 3x10-8 M) Parasite lactate dehydrogenase (pLDH ) assay following 72 hours in culture [31]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum GPI-anchored wall transfer protein 1 compound VII [WO2021149692A1] PfK1 - 7.4 pIC50 31
pIC50 7.4 (IC50 4.1x10-8 M) Parasite lactate dehydrogenase (pLDH ) assay following 72 hours in culture [31]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 AN3661 Pf3D7 - 7.3 pIC50 91
pIC50 7.3 (IC50 5.2x10-8 M) [3H]-hypoxanthine incorporation [91]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 AN3661 PfK1 - 7.7 pIC50 91
pIC50 7.7 (IC50 2x10-8 M) [3H]-hypoxanthine incorporation [91]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 AN3661 PfDd2 - 7.4 pIC50 91
pIC50 7.4 (IC50 3.9x10-8 M) [3H]-hypoxanthine incorporation [91]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 AN3661 PfHB3 - 7.3 pIC50 91
pIC50 7.3 (IC50 5.6x10-8 M) [3H]-hypoxanthine incorporation [91]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 AN3661 PfFCR3 - 7.5 pIC50 91
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [91]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum purine nucleoside phosphorylase quinine Pf - 6.9 pKi 19
pKi 6.9 (Ki 1.38x10-7 M) [19]
Plasmodium falciparum purine nucleoside phosphorylase mefloquine Pf - 5.2 pKi 19
pKi 5.2 (Ki 5.9x10-6 M) [19]
Plasmodium falciparum purine nucleoside phosphorylase forodesine Pf - 7.5 pIC50 45
pIC50 7.5 (IC50 3.5x10-8 M) Tran35S incorporation [45]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum purine nucleoside phosphorylase forodesine Pf - 9.2 pKi 44
pKi 9.2 (Ki 6x10-10 M) [44]
Plasmodium falciparum V-type proton ATPase subunit D sutidiazine PfNF54 - 8.1 pIC50 26
pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [26]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum V-type proton ATPase subunit D sutidiazine PfK1 - 7.8 pIC50 26
pIC50 7.8 (IC50 1.5x10-8 M) SYBR Green assay [26]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum heme detoxification protein Lys01 PfK1 - 7.3 pIC50 85
pIC50 7.3 (IC50 4.5x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [85]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum heme detoxification protein Lys01 PfFCR3 - 7.7 pIC50 85
pIC50 7.7 (IC50 2x10-8 M) Parasite lactate dehydrogenase (pLDH) assay [85]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone PfNF54 - 9.2 pIC50 16
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone PfV1/S - 8.9 pIC50 16
pIC50 8.9 (IC50 1.4x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone PfK1 - 9.0 pIC50 16
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone PfD6 - 10.0 pIC50 16
pIC50 10.0 (IC50 1x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone Pf7G8 - 9.5 pIC50 16
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone PfW2 - 9.7 pIC50 16
pIC50 9.7 (IC50 2x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b atovaquone PfTM90C2A - 9.3 pIC50 16
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b ELQ-300 PfNF54 - - - 61
Giemsa-stained blood film counts: treated gametocytes did not develop past stage III, even at 0.1 μM, the lowest dose tested [61]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite early stage (I–III) gametocyte assay
Plasmodium falciparum cytochrome b ELQ-300 PfNF54 - 7.1 pIC50 61
pIC50 7.1 (IC50 7.19x10-8 M) High-content fluorescence-based image analysis of gametocyte viability throughout a period of 72 hours [61]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (IV–V) gametocyte assay
Plasmodium falciparum cytochrome b ELQ-300 PfD6 - 8.5 – 8.7 pIC50 61
pIC50 8.7 (IC50 2.2x10-9 M) SYBR green method, measured at 72h [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 8.5 (IC50 3.06x10-9 M) [3H]-hypoxanthine incorporation [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b ELQ-300 PfW2 - 8.6 – 8.7 pIC50 61
pIC50 8.7 (IC50 1.8x10-9 M) SYBR green method, measured at 72h [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 8.6 (IC50 2.27x10-9 M) [3H]-hypoxanthine incorporation [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b ELQ-300 PfTM91C235 - 8.4 pIC50 61
pIC50 8.4 (IC50 4.34x10-9 M) [3H]-hypoxanthine incorporation [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b ELQ-300 PfDd2 - 8.6 pIC50 61
pIC50 8.6 (IC50 2.5x10-9 M) SYBR green method, measured at 72h [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b ELQ-300 PfTM90C2B - 8.6 – 8.8 pIC50 61
pIC50 8.8 (IC50 1.7x10-9 M) SYBR green method, measured at 72h [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 8.6 (IC50 2.84x10-9 M) [3H]-hypoxanthine incorporation [61]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b compound 11c [PMID: 30613327] Pf3D7 - 7.5 pIC50 30
pIC50 7.5 (IC50 3.3x10-8 M) SYBR Green I method, measured at 48h [30]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b compound 11c [PMID: 30613327] Pf Inhibition 9.1 pIC50 30
pIC50 9.1 (IC50 7.5x10-10 M) [30]
Plasmodium falciparum cytochrome b compound 11c [PMID: 30613327] PfW2 - 7.8 pIC50 30
pIC50 7.8 (IC50 1.5x10-8 M) SYBR Green I method, measured at 48h [30]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b compound 11c [PMID: 30613327] PfTM90C2B - 6.3 pIC50 30
pIC50 6.3 (IC50 5x10-7 M) SYBR Green I method, measured at 48h [30]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cytochrome b compound 27 [PMID: 32945666] Pf3D7 - 7.2 pEC50 20
pEC50 7.2 (EC50 7x10-8 M) SYBR Green I assay [20]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proteasome subunit beta type-5 bortezomib Pf3D7 - 7.5 pIC50 82
pIC50 7.5 (IC50 3.1x10-8 M) [3H]-hypoxanthine incorporation [82]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proteasome subunit beta type-5 bortezomib Pf Inhibition 7.3 pIC50 107
pIC50 7.3 (IC50 5.3x10-8 M) Fluorogenic peptide assay used to assess purified Pf20S proteasome activity [107]
Plasmodium falciparum proteasome subunit beta type-5 bortezomib PfW2 - 7.4 pIC50 82
pIC50 7.4 (IC50 4.3x10-8 M) [3H]-hypoxanthine incorporation [82]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proteasome subunit beta type-5 bortezomib PfDd2 - 7.4 pIC50 82
pIC50 7.4 (IC50 3.7x10-8 M) [3H]-hypoxanthine incorporation [82]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proteasome subunit beta type-5 bortezomib PfHB3 - 7.5 pIC50 82
pIC50 7.5 (IC50 3.1x10-8 M) [3H]-hypoxanthine incorporation [82]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proteasome subunit beta type-5 WLL-vs Pf - 8.2 pEC50 109
pEC50 8.2 (EC50 6x10-9 M) [109]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proteasome subunit beta type-5 WLL-vs Pf Inhibition 6.1 pIC50 52
pIC50 6.1 (IC50 8x10-7 M) [52]
Plasmodium falciparum proteasome subunit beta type-5 analog 18 [PMID: 28696697] PfNF54 - 6.9 pIC50 49
pIC50 6.9 (IC50 1.3x10-7 M) [49]
Description: Parasite late stage (V) gametocyte assay
Plasmodium falciparum proteasome subunit beta type-5 analog 18 [PMID: 28696697] PfDd2 - 8.5 pIC50 49
pIC50 8.5 (IC50 3.27x10-9 M) SYBR Green I assay (72h) [49]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum cyclin-dependent-like kinase CLK3 TCMDC-135051 Pf3D7 - 6.5 pEC50 1
pEC50 6.5 (EC50 3.2x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum cyclin-dependent-like kinase CLK3 TCMDC-135051 PfDd2 - 6.9 pEC50 1
pEC50 6.9 (EC50 1.13x10-7 M) [1]
Plasmodium falciparum plasmepsin V WEHI-842 Pf3D7 - 6.4 pEC50 28
pEC50 6.4 (EC50 4x10-7 M) [28]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum plasmepsin V WEHI-842 PfNF54 - - - 37
Oocyst count: WEHI-842 demonstrates a dose-dependent inhibitory effect on transmission fitness [37]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Plasmodium falciparum plasmepsin V WEHI-842 PfNF54 - 7.4 pEC50 37
pEC50 7.4 (EC50 4x10-8 M) Giemsa-stained blood film counts: no stage II-V gametocytes were observed [37]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte assay
Plasmodium falciparum plasmepsin V WEHI-842 Pf Inhibition 9.7 pIC50 28
pIC50 9.7 (IC50 2x10-10 M) [28]
Plasmodium falciparum Niemann-Pick type C1-related protein MMV009108 Pf3D7 - 6.3 pEC50 34
pEC50 6.3 (EC50 4.54x10-7 M) [34]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum tryptophanyl-tRNA synthetase indolmycin Pf3D7 - 5.8 pIC50 72
pIC50 5.8 (IC50 1.7x10-6 M) SYBR Green susceptibility assay determined 96 hrs after drug treatment [72]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum isoleucyl-tRNA synthetase mupirocin Pf3D7 - 7.2 pIC50 35
pIC50 7.2 (IC50 5.74x10-8 M) [35]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase MMV019313 PfW2 - 6.6 pEC50 24
pEC50 6.6 (EC50 2.7x10-7 M) [24]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase MMV019313 PfDd2 - 6.7 pEC50 24
pEC50 6.7 (EC50 1.8x10-7 M) [24]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase AIM-1290 Pf Inhibition 5.7 pIC50 41
pIC50 5.7 (IC50 1.94x10-6 M) PfGGPPS enzymatic activity [41]
Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase AIM-1290 Pf - 7.1 pIC50 41
pIC50 7.1 (IC50 7.4x10-8 M) [41]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum acetyl-CoA synthetase MMV689258 Pf - 8.3 pIC50 87
pIC50 8.3 (IC50 5x10-9 M) [87]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum acetyl-CoA synthetase MMV693183 PfNF54 - 8.1 – 8.6 pIC50 88
pIC50 8.6 (IC50 2.4x10-9 M) SYBR Green incorporation (72h assay) [88]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 8.1 (IC50 8x10-9 M) [88]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte viability assay
Plasmodium falciparum acetyl-CoA synthetase MMV693183 Pf - 8.6 pIC50 15
pIC50 8.6 (IC50 2.5x10-9 M) SYBR Green assay [15]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum subtilisin-like protease 1 compound 3j [PMID: 33975947] Pf3D7 - 6.6 pEC50 54
pEC50 6.6 (EC50 2.6x10-7 M) SYBR Green I assay [54]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum subtilisin-like protease 1 compound 3j [PMID: 33975947] Pf3D7 - 8.2 pIC50 54
pIC50 8.2 (IC50 5.7x10-9 M) [54]
Plasmodium falciparum histone acetyltransferase GCN5 SGC-CBP30 PfDd2 - 5.5 pIC50 9
pIC50 5.5 (IC50 3.16x10-6 M) [3H]-hypoxanthine incorporation assay (72 h with synchronous parasites) [9]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum histone acetyltransferase GCN5 L-45 Pf Inhibition 6.6 pKd 58
pKd 6.6 (Kd 2.8x10-7 M) [58]
Description: Isothermal titration calorimetry.
Plasmodium falciparum adenylyl cyclase beta KH7 Pf Inhibition 5.3 pIC50 86
pIC50 5.3 (IC50 5x10-6 M) [86]
Unknown MOA mefloquine PfNF54 - 8.0 pIC50 16
pIC50 8.0 (IC50 1.07x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfV1/S - 8.2 pIC50 16
pIC50 8.2 (IC50 5.7x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfK1 - 8.4 pIC50 16
pIC50 8.4 (IC50 3.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfD6 - 8.1 pIC50 16
pIC50 8.1 (IC50 8.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine Pf7G8 - 8.5 pIC50 16
pIC50 8.5 (IC50 3x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfW2 - 8.4 pIC50 16
pIC50 8.4 (IC50 4.4x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfTM90C2A - 7.8 pIC50 16
pIC50 7.8 (IC50 1.45x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA luteolin Pf3D7 - 5.0 pIC50 51
pIC50 5.0 (IC50 1.1x10-5 M) [3H]-hypoxanthine incorporation [51]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA luteolin Pf7G8 - 4.9 pIC50 51
pIC50 4.9 (IC50 1.2x10-5 M) [3H]-hypoxanthine incorporation [51]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine PfNF54 - 7.9 pIC50 16
pIC50 7.9 (IC50 1.12x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine PfV1/S - 6.5 pIC50 16
pIC50 6.5 (IC50 3.04x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine PfK1 - 6.7 pIC50 16
pIC50 6.7 (IC50 1.98x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine PfD6 - 8.1 pIC50 16
pIC50 8.1 (IC50 8.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine Pf7G8 - 7.2 pIC50 16
pIC50 7.2 (IC50 7.03x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine PfW2 - 6.6 pIC50 16
pIC50 6.6 (IC50 2.683x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA chloroquine PfTM90C2A - 7.0 pIC50 16
pIC50 7.0 (IC50 1.058x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA doxycycline Pf3D7 - 6.3 – 7.3 pIC50 12
pIC50 7.3 (IC50 4.53x10-8 M) FACS analysis following 96 hours in culture (third-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
pIC50 6.3 (IC50 5.32x10-7 M) FACS analysis following 48 hours in culture (second-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA doxycycline PfW2 - 6.5 – 7.7 pIC50 12
pIC50 7.7 (IC50 2.11x10-8 M) FACS analysis following 96 hours in culture (third-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
pIC50 6.5 (IC50 3.3x10-7 M) FACS analysis following 48 hours in culture (second-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA azithromycin Pf3D7 - 5.1 – 7.3 pIC50 12
pIC50 7.3 (IC50 5.27x10-8 M) FACS analysis following 96 hours in culture (third-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
pIC50 5.1 (IC50 8.67x10-6 M) FACS analysis following 48 hours in culture (second-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA azithromycin PfW2 - 5.8 – 7.5 pIC50 12
pIC50 7.5 (IC50 3.1x10-8 M) FACS analysis following 96 hours in culture (third-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
pIC50 5.8 (IC50 1.46x10-6 M) FACS analysis following 48 hours in culture (second-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA hydroxychloroquine PfNF54 - 7.8 pIC50 16
pIC50 7.8 (IC50 1.63x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA hydroxychloroquine PfV1/S - 5.8 pIC50 16
pIC50 5.8 (IC50 1.735x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA hydroxychloroquine PfK1 - 6.0 pIC50 16
pIC50 6.0 (IC50 9.62x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA hydroxychloroquine PfD6 - 7.8 pIC50 16
pIC50 7.8 (IC50 1.5x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA hydroxychloroquine Pf7G8 - 6.4 pIC50 16
pIC50 6.4 (IC50 4.227x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA hydroxychloroquine PfW2 - 5.9 pIC50 16
pIC50 5.9 (IC50 1.277x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA hydroxychloroquine PfTM90C2A - 6.3 pIC50 16
pIC50 6.3 (IC50 5.652x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SQ-109 PfNF54 - 7.0 pIC50 81
pIC50 7.0 (IC50 1.05x10-7 M) [81]
Description: Parasite late stage (IV–V) gametocyte assay
Unknown MOA SQ-109 Pf - - - 81
≥80% inhibition of male gamete exflagellation following 48hour exposure of mature gametocytes to 2µM SQ-109 [81]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite exflagellation assay
Unknown MOA OSM-S-38 Pf3D7 - 7.1 – 8.4 pIC50 104
pIC50 8.4 (IC50 4x10-9 M) [104]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite late stage (IV–V) gametocyte assay
pIC50 7.1 (IC50 7.9x10-8 M) [104]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA tafenoquine PfD6 - 5.8 pIC50 99
pIC50 5.8 (IC50 1.47x10-6 M) [3H]-hypoxanthine incorporation [99]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA tafenoquine PfW2 - 6.7 pIC50 99
pIC50 6.7 (IC50 2.17x10-7 M) [3H]-hypoxanthine incorporation [99]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide Pf3D7 - 8.1 pIC50 48
pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfNF54 - - - 48
Giemsa-stained blood film counts: potent inhibiton of gametocyte maturation at concentrations as low as 50 nM [48]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite gametocyte maturation assay
Oocyst count: >90% reduction of oocyst numbers at a concentration of 500 nM [48]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Unknown MOA ganaplacide PfNF54 - 7.8 pIC50 48
pIC50 7.8 (IC50 1.64x10-8 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfK1 - 8.1 pIC50 48
pIC50 8.1 (IC50 7.3x10-9 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfD6 - 8.0 pIC50 48
pIC50 8.0 (IC50 1.02x10-8 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide Pf7G8 - 8.2 pIC50 48
pIC50 8.2 (IC50 6x10-9 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfW2 - 8.1 pIC50 48
pIC50 8.1 (IC50 7.7x10-9 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfTM91C235 - 7.9 pIC50 48
pIC50 7.9 (IC50 1.14x10-8 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfDd2 - 8.1 pIC50 48
pIC50 8.1 (IC50 7.1x10-9 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfHB3 - 7.8 pIC50 48
pIC50 7.8 (IC50 1.66x10-8 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ganaplacide PfFCR3 - 8.1 pIC50 48
pIC50 8.1 (IC50 8.4x10-9 M) SYBR Green assay [48]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfNF54 - 5.9 pIC50 16
pIC50 5.9 (IC50 1.191x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfV1/S - 6.3 pIC50 16
pIC50 6.3 (IC50 5.427x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfK1 - 6.3 pIC50 16
pIC50 6.3 (IC50 5.57x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfD6 - 5.8 pIC50 16
pIC50 5.8 (IC50 1.518x10-6 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine Pf7G8 - 6.4 pIC50 16
pIC50 6.4 (IC50 4.413x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfW2 - 6.2 pIC50 16
pIC50 6.2 (IC50 6.757x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfTM90C2A - 6.2 pIC50 16
pIC50 6.2 (IC50 6.297x10-7 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfNF54 - 8.2 pIC50 16
pIC50 8.2 (IC50 5.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfV1/S - 9.2 pIC50 16
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfK1 - 8.3 pIC50 16
pIC50 8.3 (IC50 5.4x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfD6 - 9.1 pIC50 16
pIC50 9.1 (IC50 8x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin Pf7G8 - 8.5 pIC50 16
pIC50 8.5 (IC50 3x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfW2 - 8.1 pIC50 16
pIC50 8.1 (IC50 7.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfTM90C2A - 7.8 pIC50 16
pIC50 7.8 (IC50 1.51x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfNF54 - 8.5 pIC50 16
pIC50 8.5 (IC50 3.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfV1/S - 8.5 pIC50 16
pIC50 8.5 (IC50 2.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfK1 - 8.7 pIC50 16
pIC50 8.7 (IC50 2.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfD6 - 8.5 pIC50 16
pIC50 8.5 (IC50 3.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether Pf7G8 - 8.9 pIC50 16
pIC50 8.9 (IC50 1.4x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfW2 - 8.5 pIC50 16
pIC50 8.5 (IC50 3.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfTM90C2A - 8.3 pIC50 16
pIC50 8.3 (IC50 5.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfNF54 - 8.5 pIC50 16
pIC50 8.5 (IC50 3.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfV1/S - 8.5 pIC50 16
pIC50 8.5 (IC50 3.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfK1 - 8.6 pIC50 16
pIC50 8.6 (IC50 2.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfD6 - 8.3 pIC50 16
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate Pf7G8 - 8.7 pIC50 16
pIC50 8.7 (IC50 2.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfW2 - 8.5 pIC50 16
pIC50 8.5 (IC50 2.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfTM90C2A - 8.4 pIC50 16
pIC50 8.4 (IC50 4.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfNF54 - 9.0 pIC50 16
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfV1/S - 9.0 pIC50 16
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfK1 - 9.1 pIC50 16
pIC50 9.1 (IC50 8x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfD6 - 8.8 pIC50 16
pIC50 8.8 (IC50 1.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol Pf7G8 - 9.1 pIC50 16
pIC50 9.1 (IC50 7x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfW2 - 8.9 pIC50 16
pIC50 8.9 (IC50 1.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfTM90C2A - 9.0 pIC50 16
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemotil PfD6 - 8.8 pIC50 90
pIC50 8.8 (IC50 1.73x10-9 M) [3H]-hypoxanthine incorporation [90]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemotil PfW2 - 8.8 pIC50 90
pIC50 8.8 (IC50 1.57x10-9 M) [3H]-hypoxanthine incorporation [90]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfNF54 - 8.6 pIC50 16
pIC50 8.6 (IC50 2.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfV1/S - 8.9 pIC50 16
pIC50 8.9 (IC50 1.3x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfK1 - 9.0 pIC50 16
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfD6 - 8.4 pIC50 16
pIC50 8.4 (IC50 4.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine Pf7G8 - 8.9 pIC50 16
pIC50 8.9 (IC50 1.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfW2 - 8.8 pIC50 16
pIC50 8.8 (IC50 1.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfTM90C2A - 8.2 pIC50 16
pIC50 8.2 (IC50 5.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artefenomel PfNF54 - 8.7 pIC50 7
pIC50 8.7 (IC50 1.9x10-9 M) [3H]-hypoxanthine incorporation [7]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artefenomel Pf - - - 16
>60% inhibition of exflagellation following 24hour exposure of mature gametocytes to 10µM artefenomel [16]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite exflagellation assay
Unknown MOA artefenomel PfK1 - 8.8 pIC50 7
pIC50 8.8 (IC50 1.6x10-9 M) [3H]-hypoxanthine incorporation [7]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ferroquine Pf - 9.4 pIC50 5
pIC50 9.4 (IC50 3.7x10-10 M) [3H]-hypoxanthine incorporation. Strain SGE2 (Zaire) designated as chloroquine sensitive. [5]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfNF54 - 8.4 pIC50 16
pIC50 8.4 (IC50 3.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfV1/S - 8.0 pIC50 16
pIC50 8.0 (IC50 9.4x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfK1 - 8.1 pIC50 16
pIC50 8.1 (IC50 7.7x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfD6 - 8.3 pIC50 16
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine Pf7G8 - 8.0 pIC50 16
pIC50 8.0 (IC50 9.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfW2 - 8.0 pIC50 16
pIC50 8.0 (IC50 1.08x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfTM90C2A - 8.2 pIC50 16
pIC50 8.2 (IC50 5.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfNF54 - 9.1 pIC50 16
pIC50 9.1 (IC50 9x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfV1/S - 9.5 pIC50 16
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfK1 - 9.7 pIC50 16
pIC50 9.7 (IC50 2x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfD6 - 9.1 pIC50 16
pIC50 9.1 (IC50 7x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine Pf7G8 - 9.7 pIC50 16
pIC50 9.7 (IC50 2x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfW2 - 9.5 pIC50 16
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfTM90C2A - 9.0 pIC50 16
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfNF54 - 8.2 – 9.4 pIC50 50
pIC50 9.4 (IC50 4x10-10 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 8.2 (IC50 5.89x10-9 M) male gamete formation from the gametocyte stage [50]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite dual gamete formation assay (DGFA)
Conditions: ACT-451840 had no effect on the functional viability of female gametocytes up to a concentration of 20 μM.
Unknown MOA ACT-451840 PfV1/S - 9.5 pIC50 50
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 Pf - 7.5 pIC50 50
pIC50 7.5 (IC50 3x10-8 M) Indirect mode: dose-dependent inhibition of oocyst development in the mosquito was observed. Direct mode: no activity at concentrations up to 1 μM [50]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Unknown MOA ACT-451840 PfK1 - 9.5 pIC50 50
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfD6 - 9.3 pIC50 50
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 Pf7G8 - 9.5 pIC50 50
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfW2 - 9.7 pIC50 50
pIC50 9.7 (IC50 2x10-10 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfTM90C2A - 9.0 pIC50 50
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation [50]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfNF54 - 8.1 pIC50 16
pIC50 8.1 (IC50 8.3x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfV1/S - 8.0 pIC50 16
pIC50 8.0 (IC50 1.05x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfK1 - 8.1 pIC50 16
pIC50 8.1 (IC50 9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfD6 - 8.1 pIC50 16
pIC50 8.1 (IC50 8.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine Pf7G8 - 8.1 pIC50 16
pIC50 8.1 (IC50 8.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfW2 - 8.0 pIC50 16
pIC50 8.0 (IC50 9.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfTM90C2A - 8.1 pIC50 16
pIC50 8.1 (IC50 7.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 Pf3D7 - 7.4 pIC50 112
pIC50 7.4 (IC50 4.3x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfNF54 - 7.4 pIC50 112
pIC50 7.4 (IC50 3.6x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfV1/S - 7.2 pIC50 112
pIC50 7.2 (IC50 6.3x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfK1 - 7.2 pIC50 112
pIC50 7.2 (IC50 6.2x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfD6 - 7.2 pIC50 112
pIC50 7.2 (IC50 6.2x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 Pf7G8 - 7.5 pIC50 112
pIC50 7.5 (IC50 3.5x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfW2 - 7.5 pIC50 112
pIC50 7.5 (IC50 3.26x10-8 M) FACS analysis (YOYO-1 staining) [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfTM90C2A - 7.2 pIC50 112
pIC50 7.2 (IC50 6.4x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfDd2 - 7.3 pIC50 112
pIC50 7.3 (IC50 5.3x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AN13762 PfHB3 - 7.1 pIC50 112
pIC50 7.1 (IC50 8x10-8 M) [3H]-hypoxanthine incorporation [112]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine PfNF54 - 8.3 pIC50 16
pIC50 8.3 (IC50 4.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine PfV1/S - 8.2 pIC50 16
pIC50 8.2 (IC50 6.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine PfK1 - 8.2 pIC50 16
pIC50 8.2 (IC50 6.7x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine PfD6 - 8.4 pIC50 16
pIC50 8.4 (IC50 4.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine Pf7G8 - 8.2 pIC50 16
pIC50 8.2 (IC50 5.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine PfW2 - 8.0 pIC50 16
pIC50 8.0 (IC50 9.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA pyronaridine PfTM90C2A - 8.3 pIC50 16
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mepacrine PfNF54 - 8.1 pIC50 21
pIC50 8.1 (IC50 8.3x10-9 M) [3H]-hypoxanthine incorporation [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mepacrine PfK1 - 7.4 pIC50 21
pIC50 7.4 (IC50 3.99x10-8 M) [3H]-hypoxanthine incorporation [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 Pf3D7 - 8.1 pIC50 73
pIC50 8.1 (IC50 8x10-9 M) [73]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 PfNF54 - 8.7 pIC50 73
pIC50 8.7 (IC50 2x10-9 M) [73]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 PfK1 - 8.3 pIC50 73
pIC50 8.3 (IC50 5x10-9 M) [73]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 Pf7G8 - 8.0 pIC50 73
pIC50 8.0 (IC50 1x10-8 M) [73]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 PfDd2 - 8.5 pIC50 73
pIC50 8.5 (IC50 3x10-9 M) [73]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 PfFCR3 - 8.2 pIC50 73
pIC50 8.2 (IC50 6x10-9 M) [73]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 PfNF54 - 8.3 pIC50 16
pIC50 8.3 (IC50 5.3x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 PfV1/S - 7.5 pIC50 16
pIC50 7.5 (IC50 3.2x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 PfK1 - 7.7 pIC50 16
pIC50 7.7 (IC50 2x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 PfD6 - 8.1 pIC50 16
pIC50 8.1 (IC50 7.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 Pf7G8 - 7.8 pIC50 16
pIC50 7.8 (IC50 1.47x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 PfW2 - 7.6 pIC50 16
pIC50 7.6 (IC50 2.7x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA AQ-13 PfTM90C2A - 8.0 pIC50 16
pIC50 8.0 (IC50 1.08x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA tebuquine PfK1 - 7.7 pIC50 66
pIC50 7.7 (IC50 2.08x10-8 M) [3H]-hypoxanthine incorporation [66]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA tebuquine PfHB3 - 9.1 pIC50 66
pIC50 9.1 (IC50 9x10-10 M) [3H]-hypoxanthine incorporation [66]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA JPC-3210 PfD6 - 8.1 pIC50 8
pIC50 8.1 (IC50 9x10-9 M) [8]
Unknown MOA JPC-3210 Pf7G8 - 8.1 pIC50 8
pIC50 8.1 (IC50 7x10-9 M) [8]
Unknown MOA JPC-3210 PfTM91C235 - 7.8 pIC50 8
pIC50 7.8 (IC50 1.7x10-8 M) [8]
Unknown MOA naphthoquine PfNF54 - 8.5 pIC50 16
pIC50 8.5 (IC50 3.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA naphthoquine PfV1/S - 8.6 pIC50 16
pIC50 8.6 (IC50 2.8x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA naphthoquine PfK1 - 8.4 pIC50 16
pIC50 8.4 (IC50 4.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA naphthoquine PfD6 - 8.5 pIC50 16
pIC50 8.5 (IC50 3x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA naphthoquine Pf7G8 - 8.7 pIC50 16
pIC50 8.7 (IC50 2.1x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA naphthoquine PfW2 - 8.3 pIC50 16
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA naphthoquine PfTM90C2A - 8.3 pIC50 16
pIC50 8.3 (IC50 5.2x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA arteflene PfNF54 - 7.3 – 7.3 pIC50 36
pIC50 7.3 (IC50 4.42x10-8 M) [3H]-hypoxanthine incorporation, measured after 48 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 7.3 (IC50 4.6x10-8 M) [3H]-hypoxanthine incorporation, measured after 72 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA arteflene PfK1 - 7.5 – 7.5 pIC50 36
pIC50 7.5 (IC50 3.1x10-8 M) [3H]-hypoxanthine incorporation, measured after 48 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 7.5 (IC50 3.24x10-8 M) [3H]-hypoxanthine incorporation, measured after 72 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA arteflene PfW2 - 7.5 – 7.7 pIC50 36
pIC50 7.7 (IC50 2.11x10-8 M) [3H]-hypoxanthine incorporation, measured after 48 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 7.5 (IC50 3.25x10-8 M) [3H]-hypoxanthine incorporation, measured after 72 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA arteflene PfHB3 - 7.4 – 7.5 pIC50 36
pIC50 7.5 (IC50 3.15x10-8 M) [3H]-hypoxanthine incorporation, measured after 48 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 7.4 (IC50 4.36x10-8 M) [3H]-hypoxanthine incorporation, measured after 72 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA arteflene PfFCR3 - 7.6 – 7.7 pIC50 36
pIC50 7.7 (IC50 2.23x10-8 M) [3H]-hypoxanthine incorporation, measured after 72 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 7.6 (IC50 2.27x10-8 M) [3H]-hypoxanthine incorporation, measured after 48 hours in culture [36]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA albitiazolium Pf3D7 - 8.6 pIC50 100
pIC50 8.6 (IC50 2.3x10-9 M) [100]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA MK-4815 Pf3D7 - 7.5 pIC50 79
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [79]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MK-4815 PfNF54 - 7.4 pIC50 79
pIC50 7.4 (IC50 3.8x10-8 M) [3H]-hypoxanthine incorporation [79]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MK-4815 PfV1/S - 8.1 pIC50 79
pIC50 8.1 (IC50 7x10-9 M) [3H]-hypoxanthine incorporation [79]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MK-4815 PfK1 - 8.4 pIC50 79
pIC50 8.4 (IC50 4x10-9 M) [3H]-hypoxanthine incorporation [79]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MK-4815 PfDd2 - 7.4 pIC50 79
pIC50 7.4 (IC50 4x10-8 M) [3H]-hypoxanthine incorporation [79]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MK-4815 PfFCR3 - 8.0 pIC50 79
pIC50 8.0 (IC50 1x10-8 M) [3H]-hypoxanthine incorporation [79]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 Pf3D7 - 7.9 pIC50 65
pIC50 7.9 (IC50 1.12x10-8 M) [3H]-hypoxanthine incorporation [65]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 PfNF54 - 8.3 pIC50 16
pIC50 8.3 (IC50 5.4x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 PfV1/S - 7.8 pIC50 16
pIC50 7.8 (IC50 1.6x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 Pf - - - 16
Total inhibition of exflagellation following 24hour exposure of mature gametocytes to 10µM GSK369796 [16]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Parasite exflagellation assay
Unknown MOA GSK369796 PfK1 - 7.9 pIC50 16,65
pIC50 7.9 (IC50 1.33x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pIC50 7.9 (IC50 1.32x10-8 M) [3H]-hypoxanthine incorporation [65]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 PfD6 - 8.2 pIC50 16
pIC50 8.2 (IC50 6.5x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 Pf7G8 - 8.4 pIC50 16
pIC50 8.4 (IC50 3.9x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 PfW2 - 8.0 pIC50 16
pIC50 8.0 (IC50 1.01x10-8 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 PfTM90C2A - 8.2 pIC50 16
pIC50 8.2 (IC50 6x10-9 M) [3H]-hypoxanthine incorporation [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA GSK369796 PfHB3 - 7.9 pIC50 65
pIC50 7.9 (IC50 1.26x10-8 M) [3H]-hypoxanthine incorporation [65]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 Pf3D7 - 8.3 pIC50 64
pIC50 8.3 (IC50 5.1x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 PfNF54 - 8.3 pIC50 64
pIC50 8.3 (IC50 5.2x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 PfV1/S - 8.4 pIC50 64
pIC50 8.4 (IC50 4.2x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 Pf - 7.8 pIC50 64
pIC50 7.8 (IC50 1.45x10-8 M) determined by the reduction in oocyst mean intensity. A corresponding ~60 and 90% transmission blocking activity (defined as the percentage of mosquitoes with no observed oocysts) was determined at 100nM and 1µM, respectively [64]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
Description: Standard membrane feeding assay (SMFA)
Unknown MOA E209 PfK1 - 8.4 pIC50 64
pIC50 8.4 (IC50 4.2x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 PfD6 - 8.1 pIC50 64
pIC50 8.1 (IC50 8.5x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 Pf7G8 - 8.5 pIC50 64
pIC50 8.5 (IC50 2.9x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 PfDd2 - 8.1 pIC50 64
pIC50 8.1 (IC50 7.7x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 PfHB3 - 8.4 pIC50 64
pIC50 8.4 (IC50 4.2x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA E209 PfTM90C2B - 8.1 pIC50 64
pIC50 8.1 (IC50 7.3x10-9 M) [3H]-hypoxanthine incorporation [64]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA clindamycin Pf3D7 - 4.0 – 8.1 pIC50 12
pIC50 8.1 (IC50 8.81x10-9 M) FACS analysis following 96 hours in culture (third-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
pIC50 <4.0 (IC50 >1x10-4 M) FACS analysis following 48 hours in culture (second-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA clindamycin PfW2 - 4.0 – 8.5 pIC50 12
pIC50 8.5 (IC50 3.12x10-9 M) FACS analysis following 96 hours in culture (third-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
pIC50 <4.0 (IC50 >1x10-4 M) FACS analysis following 48 hours in culture (second-generation rings) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA BCH070 Pf3D7 - 5.6 pIC50 11
pIC50 5.6 (IC50 2.7x10-6 M) SYBR Green I fluorescence [11]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA BCH070 PfDd2 - 6.1 pIC50 11
pIC50 6.1 (IC50 8x10-7 M) [11]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA compound 28 [PMID: 31188540] Pf3D7 - 8.1 pEC50 62
pEC50 8.1 (EC50 7x10-9 M) [62]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 3 [PMID: 32258933] PfNF54 - 7.2 pIC50 59
pIC50 7.2 (IC50 6.2x10-8 M) Lactate dehydrogenase (pLDH) assay [59]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 3 [PMID: 32258933] PfK1 - 7.3 pIC50 59
pIC50 7.3 (IC50 5.4x10-8 M) Lactate dehydrogenase (pLDH) assay [59]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA methnaridine Pf3D7 - 8.2 pIC50 103
pIC50 8.2 (IC50 6.6x10-9 M) SYBR Green I assay [103]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA methnaridine PfDd2 - 8.3 pIC50 103
pIC50 8.3 (IC50 5.6x10-9 M) SYBR Green I assay [103]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 24 [PMID: 32959656] Pf3D7 - 6.3 – 7.8 pEC50 32
pEC50 7.8 (EC50 1.68x10-8 M) SYBR Green I assay [32]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pEC50 6.4 (EC50 3.936x10-7 M) [32]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite late stage (IV–V) gametocyte assay
pEC50 6.3 (EC50 4.715x10-7 M) [32]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
Description: Parasite early stage (II–III) gametocyte assay
Unknown MOA compound 24 [PMID: 32959656] PfDd2 - 8.0 pEC50 32
pEC50 8.0 (EC50 1.09x10-8 M) SYBR Green I assay [32]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] Pf3D7 - 8.2 pIC50 74
pIC50 8.2 (IC50 6x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] PfV1/S - 8.3 pIC50 74
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] PfK1 - 8.3 pIC50 74
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] Pf7G8 - 8.5 pIC50 74
pIC50 8.5 (IC50 3x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] PfW2 - 8.1 pIC50 74
pIC50 8.1 (IC50 7x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] PfDd2 - 8.2 pIC50 74
pIC50 8.2 (IC50 6x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 2 [PMID: 33085774] PfFCR3 - 8.3 pIC50 74
pIC50 8.3 (IC50 5x10-9 M) [3H]-hypoxanthine incorporation [74]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MMV688533 Pf3D7 - 8.7 pIC50 60
pIC50 8.7 (IC50 1.9x10-9 M) SYBR Green I assay (72h) [60]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MMV688533 PfK1 - 7.7 pIC50 60
pIC50 7.7 (IC50 1.9x10-8 M) SYBR Green I assay (72h) [60]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MMV688533 PfDd2 - 8.5 pIC50 60
pIC50 8.5 (IC50 3x10-9 M) SYBR Green I assay (72h) [60]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA MMV688533 PfFC27 - 8.0 pIC50 60
pIC50 8.0 (IC50 9.7x10-9 M) SYBR Green I assay (72h) [60]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA INE963 Pf3D7 - 8.2 – 8.5 pEC50 93
pEC50 8.5 (EC50 3x10-9 M) [3H]-hypoxanthine incorporation [93]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pEC50 8.2 (EC50 6x10-9 M) SYBR green assay [93]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA compound 4 [WO2022008639A1] Pf3D7 - 8.4 pIC50 13
pIC50 8.4 (IC50 4x10-9 M) SYBER Green assay (72h) [13]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay

References

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