staurosporine

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx

Reference: 1-2
Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C gamma PKCγ/PKCg Hs Inhibitor Inhibition -3.2 1.5 1.0
calcium/calmodulin dependent protein kinase kinase 1 nd/CAMKK1 Hs Inhibitor Inhibition -3.1
ribosomal protein S6 kinase A3 Rsk2/RSK2 Hs Inhibitor Inhibition -1.3 0.0 0.0
TANK binding kinase 1 TBK1/TBK1 Hs Inhibitor Inhibition -0.5 1.5 0.5
serine/threonine kinase 4 MST1/MST1(STK4) Hs Inhibitor Inhibition -0.2 -0.5 1.0
microtubule affinity regulating kinase 4 nd/MARK4 Hs Inhibitor Inhibition 0.0
microtubule affinity regulating kinase 2 PAR-1Bα/MARK2(PAR-1Ba) Hs Inhibitor Inhibition 0.0 -1.0 0.0
ribosomal protein S6 kinase B1 p70S6K/p70S6K(RPS6KB1) Hs Inhibitor Inhibition 0.1 1.5 3.0
protein kinase N1 nd/PKN1(PRK1) Hs Inhibitor Inhibition 0.1
salt inducible kinase 2 nd/SIK2 Hs Inhibitor Inhibition 0.1
microtubule affinity regulating kinase 1 MARK1/MARK1 Hs Inhibitor Inhibition 0.2 -0.5 0.0
calcium/calmodulin dependent protein kinase kinase 2 nd/CAMKK2 Hs Inhibitor Inhibition 0.2
FGR proto-oncogene, Src family tyrosine kinase Fgr/FGR Hs Inhibitor Inhibition 0.3 0.5 1.0
serine/threonine kinase 10 LOK/LOK(STK10) Hs Inhibitor Inhibition 0.3 1.0 1.0
inhibitor of nuclear factor kappa B kinase subunit epsilon nd/IKKe(IKBKE) Hs Inhibitor Inhibition 0.3
cyclin dependent kinase 2 CDK2-cyclin A/CDK2-cyclin A Hs Inhibitor Inhibition 0.3 -1.0 0.0
protein kinase C eta PKCη/PKCeta Hs Inhibitor Inhibition 0.4 2.5 0.0
neurotrophic receptor tyrosine kinase 2 TrkB/TRKB Hs Inhibitor Inhibition 0.4 14.5 -6.0
mitogen-activated protein kinase kinase kinase kinase 2 GCK/GCK(MAP4K2) Hs Inhibitor Inhibition 0.5 -1.0 1.5
leukocyte receptor tyrosine kinase nd/TYK1(LTK) Hs Inhibitor Inhibition 0.5
mitogen-activated protein kinase kinase kinase kinase 5 nd/KHS(MAP4K5) Hs Inhibitor Inhibition 0.5
calcium/calmodulin-dependent protein kinase II alpha subunit nd/CAMK2a Hs Inhibitor Inhibition 0.5
BR serine/threonine kinase 1 BrSK1/BRSK1 Hs Inhibitor Inhibition 0.5 1.0 -0.5
ret proto-oncogene Ret/RET Hs Inhibitor Inhibition 0.6 3.5 6.0
Rho associated coiled-coil containing protein kinase 1 ROCK-I/ROCK1 Hs Inhibitor Inhibition 0.6 4.5 1.5
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 0.6 4.0 0.0
G protein-coupled receptor kinase 7 GRK7/GRK7 Hs Inhibitor Inhibition 0.7 0.5 2.5
Rho associated coiled-coil containing protein kinase 2 ROCK-II/ROCK2 Hs Inhibitor Inhibition 0.7 1.0 0.0
calcium/calmodulin-dependent protein kinase II gamma subunit CaMKIIγ/CAMK2g Hs Inhibitor Inhibition 0.7 0.5 -3.5
p21 (RAC1) activated kinase 2 PAK2/PAK2 Hs Inhibitor Inhibition 0.7 5.5 -0.5
Janus kinase 3 JAK3/JAK3 Hs Inhibitor Inhibition 0.7 0.0 0.5
microtubule affinity regulating kinase 3 nd/MARK3 Hs Inhibitor Inhibition 0.7
FER tyrosine kinase Fer/FER Hs Inhibitor Inhibition 0.8 2.0 0.5
protein kinase C epsilon PKCε/PKCepsilon Hs Inhibitor Inhibition 0.8 1.0 -0.5
neurotrophic receptor tyrosine kinase 1 TrkA/TRKA Hs Inhibitor Inhibition 0.8 0.0 0.0
dual specificity tyrosine phosphorylation regulated kinase 1B nd/DYRK1B Hs Inhibitor Inhibition 0.8
c-ros oncogene 1, receptor tyrosine kinase Ros/ROS(ROS1) Hs Inhibitor Inhibition 0.9 3.5 1.5
calcium/calmodulin dependent protein kinase ID CaMKIδ/CAMK1d Hs Inhibitor Inhibition 0.9 3.0 1.0
TAO kinase 1 TAO1/TAOK1 Hs Inhibitor Inhibition 0.9 0.0 0.5
ALK receptor tyrosine kinase ALK/ALK Hs Inhibitor Inhibition 0.9 0.0 0.5
leucine rich repeat kinase 2 nd/LRRK2 Hs Inhibitor Inhibition 1.0
maternal embryonic leucine zipper kinase MELK/MELK Hs Inhibitor Inhibition 1.0 1.0 -1.5
testis specific serine kinase 1B TSSK1/STK22D(TSSK1) Hs Inhibitor Inhibition 1.0 0.0 -1.0
protein kinase D2 PKD2/PKD2(PRKD2) Hs Inhibitor Inhibition 1.0 5.0 0.5
neurotrophic receptor tyrosine kinase 3 nd/TRKC Hs Inhibitor Inhibition 1.0
TAO kinase 2 TAO2/TAOK2(TAO1) Hs Inhibitor Inhibition 1.0 0.5 -0.5
protein kinase D3 nd/PKCnu(PRKD3) Hs Inhibitor Inhibition 1.0
cyclin dependent kinase 6 CDK6-cyclin D3/CDK6-cyclin D1 Hs Inhibitor Inhibition 1.0 40.5 8.5
serine/threonine kinase 3 MST2/MST2(STK3) Hs Inhibitor Inhibition 1.1 4.5 0.0
fms related receptor tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 1.1 -0.5 -0.5
mitogen-activated protein kinase kinase kinase 11 nd/MLK3(MAP3K11) Hs Inhibitor Inhibition 1.1
testis specific serine kinase 2 TSSK2/TSSK2 Hs Inhibitor Inhibition 1.2 -0.5 0.5
LYN proto-oncogene, Src family tyrosine kinase Lyn/LYN Hs Inhibitor Inhibition 1.2 0.5 0.0
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 1.2 0.5 -0.5
ribosomal protein S6 kinase A5 MSK1/MSK1(RPS6KA5) Hs Inhibitor Inhibition 1.2 0.5 -0.5
mitogen-activated protein kinase kinase kinase 2 nd/MEKK2 Hs Inhibitor Inhibition 1.2
checkpoint kinase 2 CHK2/CHK2 Hs Inhibitor Inhibition 1.3 3.0 0.5
cyclin dependent kinase 9 CDK9-cyclin T1/CDK9-cyclin T1 Hs Inhibitor Inhibition 1.4 1.0 1.0
phosphorylase kinase catalytic subunit gamma 1 nd/PHKg1 Hs Inhibitor Inhibition 1.4
protein kinase D1 PKCμ/PKCmu(PRKD1) Hs Inhibitor Inhibition 1.4 1.5 -1.5
SRC proto-oncogene, non-receptor tyrosine kinase cSrc/c-SRC Hs Inhibitor Inhibition 1.5 3.5 -1.0
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 1.5 0.5 0.5
p21 (RAC1) activated kinase 1 nd/PAK1 Hs Inhibitor Inhibition 1.6
ribosomal protein S6 kinase A2 Rsk3/RSK3 Hs Inhibitor Inhibition 1.6 1.0 0.0
BLK proto-oncogene, Src family tyrosine kinase Blk/BLK Hs Inhibitor Inhibition 1.6 -0.5 0.5
calcium/calmodulin-dependent protein kinase II beta subunit CaMKIIβ/CAMK2b Hs Inhibitor Inhibition 1.6 -1.0 1.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 1.6 0.5 1.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 1.6 4.0 0.5
misshapen like kinase 1 MINK/MINK(MINK1) Hs Inhibitor Inhibition 1.6 0.5 0.5
checkpoint kinase 1 CHK1/CHK1 Hs Inhibitor Inhibition 1.6 -1.0 -0.5
CDC42 binding protein kinase alpha MRCKα/MRCKa(CDC42BPA) Hs Inhibitor Inhibition 1.7 1.5 0.0
ribosomal protein S6 kinase A6 Rsk4/RSK4 Hs Inhibitor Inhibition 1.7 2.0 1.0
fibroblast growth factor receptor 1 FGFR1/FGFR1 Hs Inhibitor Inhibition 1.7 0.5 -0.5
Insulin receptor-related receptor IRR/IRR(INSRR) Hs Inhibitor Inhibition 1.7 1.5 1.0
STE20 like kinase nd/SLK(STK2) Hs Inhibitor Inhibition 1.8
unc-51 like kinase 3 ULK3/ULK3 Hs Inhibitor Inhibition 1.8 -1.0 0.5
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 1.8 0.5 0.0
LCK proto-oncogene, Src family tyrosine kinase Lck/LCK Hs Inhibitor Inhibition 1.8 -0.5 4.5
cyclin dependent kinase 5 CDK5-p35/CDK5-p35 Hs Inhibitor Inhibition 1.9 0.5 -0.5
Janus kinase 2 JAK2/JAK2 Hs Inhibitor Inhibition 1.9 0.0 -1.5
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 1.9
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 1.9
death associated protein kinase 3 ZIPK/ZIPK(DAPK3) Hs Inhibitor Inhibition 1.9 1.5 -1.0
protein kinase, cAMP-dependent, catalytic, alpha subunit PKA/PKA Hs Inhibitor Inhibition 1.9 0.5 2.5
CDC42 binding protein kinase beta MRCKβ/MRCKb(CDC42BPB) Hs Inhibitor Inhibition 2.0 -0.5 0.0
TAO kinase 3 TAO3/TAOK3(JIK) Hs Inhibitor Inhibition 2.1 -0.5 0.0
Janus kinase 1 nd/JAK1 Hs Inhibitor Inhibition 2.1
platelet derived growth factor receptor alpha PDGFRα/PDGFRa Hs Inhibitor Inhibition 2.1 5.5 0.5
calcium/calmodulin dependent protein kinase I CaMKI/CAMK1a Hs Inhibitor Inhibition 2.2 1.5 2.5
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 2.2 -1.5 0.0
myosin light chain kinase MLCK/MLCK(MYLK) Hs Inhibitor Inhibition 2.2 0.0 0.5
platelet derived growth factor receptor beta PDGFRβ/PDGFRb Hs Inhibitor Inhibition 2.3 3.0 1.0
p21 (RAC1) activated kinase 5 PAK5/PAK5 Hs Inhibitor Inhibition 2.3 1.0 0.5
p21 (RAC1) activated kinase 3 PAK3/PAK3 Hs Inhibitor Inhibition 2.4 1.5 4.0
aurora kinase A Aurora-A/Aurora A Hs Inhibitor Inhibition 2.4 -5.5 -2.0
MER proto-oncogene, tyrosine kinase Mer/c-MER Hs Inhibitor Inhibition 2.6 2.0 0.5
cyclin dependent kinase 1 nd/CDK1-cyclin A Hs Inhibitor Inhibition 2.7
unc-51 like autophagy activating kinase 2 ULK2/ULK2 Hs Inhibitor Inhibition 2.7 1.0 0.0
protein tyrosine kinase 2 beta Pyk2/PYK2 Hs Inhibitor Inhibition 2.7 1.5 0.5
myosin IIIB nd/MYO3b Hs Inhibitor Inhibition 2.8
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 2.8 0.5 1.0
protein kinase C theta PKCθ/PKCtheta Hs Inhibitor Inhibition 2.8 1.0 0.5
tousled like kinase 2 TLK2/TLK2 Hs Inhibitor Inhibition 2.8 0.5 0.5
IL2 inducible T cell kinase Itk/ITK Hs Inhibitor Inhibition 2.9 2.5 0.5
protein kinase C beta PKCβII/PKCb2 Hs Inhibitor Inhibition 3.0 3.5 2.0
protein kinase N2 PRK2/PKN2(PRK2) Hs Inhibitor Inhibition 3.0 1.0 1.5
AKT serine/threonine kinase 3 PKBγ/AKT3 Hs Inhibitor Inhibition 3.0 0.0 0.5
protein kinase, cAMP-dependent, catalytic, gamma subunit nd/PKAcg Hs Inhibitor Inhibition 3.0
Insulin receptor IR/IR Hs Inhibitor Inhibition 3.1 19.5 3.0
calcium/calmodulin-dependent protein kinase II delta subunit CaMKIIδ/CAMK2d Hs Inhibitor Inhibition 3.1 0.5 0.0
serine/threonine kinase 17a DRAK1/DRAK1(STK17A) Hs Inhibitor Inhibition 3.1 1.0 -0.5
fibroblast growth factor receptor 2 FGFR2/FGFR2 Hs Inhibitor Inhibition 3.2 1.0 0.0
serine/threonine kinase 25 nd/STK25(YSK1) Hs Inhibitor Inhibition 3.2
unc-51 like autophagy activating kinase 1 nd/ULK1 Hs Inhibitor Inhibition 3.3
mitogen-activated protein kinase kinase kinase 10 nd/MLK2(MAP3K10) Hs Inhibitor Inhibition 3.3
Protein kinase G (PKG) 1 PKG1β/PKG1b Hs Inhibitor Inhibition 3.3 1.0 0.5
HCK proto-oncogene, Src family tyrosine kinase Hck/HCK Hs Inhibitor Inhibition 3.3 1.5 2.0
phosphorylase kinase catalytic subunit gamma 2 PhKγ2/PHKg2 Hs Inhibitor Inhibition 3.4 3.5 1.0
protein kinase X-linked PrKX/PRKX Hs Inhibitor Inhibition 3.5 0.0 0.0
ribosomal protein S6 kinase A1 Rsk1/RSK1 Hs Inhibitor Inhibition 3.5 3.5 1.0
interleukin 1 receptor associated kinase 4 IRAK4/IRAK4 Hs Inhibitor Inhibition 3.5 1.0 0.5
BR serine/threonine kinase 2 BrSK2/BRSK2 Hs Inhibitor Inhibition 3.5 0.0 -1.0
FYN proto-oncogene, Src family tyrosine kinase Fyn/FYN Hs Inhibitor Inhibition 3.6 -0.5 -1.0
death associated protein kinase 1 DAPK1/DAPK1 Hs Inhibitor Inhibition 3.6 6.0 0.5
fibroblast growth factor receptor 3 FGFR3/FGFR3 Hs Inhibitor Inhibition 3.7 2.0 -0.5
CDC like kinase 2 CLK2/CLK2 Hs Inhibitor Inhibition 3.7 1.0 1.0
PAS domain containing serine/threonine kinase PASK/PASK Hs Inhibitor Inhibition 3.7 4.5 -1.5
discoidin domain receptor tyrosine kinase 2 DDR2/DDR2 Hs Inhibitor Inhibition 3.8 4.0 0.0
mitogen-activated protein kinase kinase 1 MEK1/MEK1 Hs Inhibitor Inhibition 3.8 3.0 0.0
NIMA related kinase 1 nd/NEK1 Hs Inhibitor Inhibition 4.0
protein kinase C beta PKCβI/PKCb1 Hs Inhibitor Inhibition 4.1 1.0 1.0
FES proto-oncogene, tyrosine kinase Fes/FES Hs Inhibitor Inhibition 4.1 0.0 0.0
death associated protein kinase 2 DAPK2/DAPK2 Hs Inhibitor Inhibition 4.1 2.5 0.0
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 4.3 0.5 -0.5
protein tyrosine kinase 2 FAK/FAK(PTK2) Hs Inhibitor Inhibition 4.3 5.5 -0.5
fms related receptor tyrosine kinase 4 Flt4/FLT4 Hs Inhibitor Inhibition 4.3 -0.5 0.0
glycogen synthase kinase 3 beta GSK3β/GSK3b Hs Inhibitor Inhibition 4.4 7.5 4.5
3-phosphoinositide dependent protein kinase 1 PDK1/PDK1(PDPK1) Hs Inhibitor Inhibition 4.4 0.5 0.0
serine/threonine-protein kinase MST4 nd/MSTR4 Hs Inhibitor Inhibition 4.4
kinase insert domain receptor KDR/KDR(VEGFR2) Hs Inhibitor Inhibition 4.5 1.5 0.5
YES proto-oncogene 1, Src family tyrosine kinase Tes/YES(YES1) Hs Inhibitor Inhibition 4.5 1.0 -0.5
dual specificity tyrosine phosphorylation regulated kinase 1A nd/DYRK1(DYRK1A) Hs Inhibitor Inhibition 4.6
protein kinase C iota PKCι/PKCiota Hs Inhibitor Inhibition 4.6 56.5 9.0
p21 (RAC1) activated kinase 6 PAK6/PAK6 Hs Inhibitor Inhibition 4.7 -1.0 -1.0
ribosomal protein S6 kinase B2 nd/p70S6Kb(RPS6KB2) Hs Inhibitor Inhibition 4.7
calcium/calmodulin dependent protein kinase IG nd/CAMK1g Hs Inhibitor Inhibition 4.7
spleen associated tyrosine kinase Syk/SYK Hs Inhibitor Inhibition 4.7 1.0 0.5
mitogen-activated protein kinase kinase kinase 5 ASK1/ASK1(MAP3K5) Hs Inhibitor Inhibition 4.7 1.5 -1.0
DM1 protein kinase DMPK/DMPK Hs Inhibitor Inhibition 4.8 13.5 7.0
pregnancy up-regulated nonubiquitous CaM kinase nd/CAMK1b Hs Inhibitor Inhibition 4.8
p21 (RAC1) activated kinase 4 PAK4/PAK4 Hs Inhibitor Inhibition 4.9 0.0 0.0
MAPK interacting serine/threonine kinase 2 Mnk2/MNK2 Hs Inhibitor Inhibition 5.0 9.5 4.0
Protein kinase G (PKG) 1 PKG1α/PKG1a Hs Inhibitor Inhibition 5.0 3.0 3.0
cyclin dependent kinase 4 nd/CDK4/cyclin D1 Hs Inhibitor Inhibition 5.0
aurora kinase C Aurora-C/Aurora C Hs Inhibitor Inhibition 5.2 3.0 1.0
ABL proto-oncogene 2, non-receptor tyrosine kinase Arg/ABL2(ARG) Hs Inhibitor Inhibition 5.3 3.5 -1.0
mitogen-activated protein kinase kinase kinase 3 nd/MEKK3 Hs Inhibitor Inhibition 5.4
zeta chain of T cell receptor associated protein kinase 70 ZAP-70/ZAP70 Hs Inhibitor Inhibition 5.4 5.5 0.0
AKT serine/threonine kinase 2 PKBβ/AKT2 Hs Inhibitor Inhibition 5.5 5.0 1.5
fyn related Src family tyrosine kinase PTK5/FRK(PTK5) Hs Inhibitor Inhibition 5.5 1.5 0.0
LIM domain kinase 1 LIMK1/LIMK1 Hs Inhibitor Inhibition 5.5 1.5 1.5
EPH receptor A6 nd/EPHA6 Hs Inhibitor Inhibition 5.6
protein kinase C delta PKCδ/PKCd Hs Inhibitor Inhibition 5.6 0.5 0.5
LYN proto-oncogene, Src family tyrosine kinase nd/LYN B Hs Inhibitor Inhibition 5.7
glycogen synthase kinase 3 alpha GSK3α/GSK3a Hs Inhibitor Inhibition 5.8 1.0 -1.5
BMX non-receptor tyrosine kinase Bmx/BMX(ETK) Hs Inhibitor Inhibition 6.2 2.5 1.5
CDC like kinase 4 nd/CLK4 Hs Inhibitor Inhibition 6.6
EPH receptor A4 EphA4/EPHA4 Hs Inhibitor Inhibition 6.7 17.0 1.0
ribosomal protein S6 kinase A4 MSK2/MSK2(RPS6KA4) Hs Inhibitor Inhibition 6.7 0.5 -0.5
histone H3 associated protein kinase Haspin/Haspin Hs Inhibitor Inhibition 6.9 1.0 2.5
mitogen-activated protein kinase kinase kinase 9 MLK1/MLK19MAP3K90 Hs Inhibitor Inhibition 7.1 0.0 0.5
Protein kinase G (PKG) 2 nd/PKG2(PRKG2) Hs Inhibitor Inhibition 7.1
TYRO3 protein tyrosine kinase Rse/TYRO3(SKY) Hs Inhibitor Inhibition 7.3 1.5 -0.5
TXK tyrosine kinase Txk/TXK Hs Inhibitor Inhibition 7.3 22.5 4.0
G protein-coupled receptor kinase 6 GRK6/GRK6 Hs Inhibitor Inhibition 7.4 16.0 0.5
AKT serine/threonine kinase 1 PKBα/AKT1 Hs Inhibitor Inhibition 7.5 10.5 3.0
interleukin 1 receptor associated kinase 1 IRAK1/IRAK1 Hs Inhibitor Inhibition 7.5 5.5 -0.5
myosin light chain kinase 2 nd/MLCK2(MYLK2) Hs Inhibitor Inhibition 7.6
Bruton tyrosine kinase BTK/BTK Hs Inhibitor Inhibition 7.8 2.5 -1.0
serum/glucocorticoid regulated kinase 2 SGK2/SGK2 Hs Inhibitor Inhibition 7.8 13.5 3.0
fms related receptor tyrosine kinase 1 Flt1/FLT1(VEGFR1) Hs Inhibitor Inhibition 7.9 0.0 -0.5
mitogen-activated protein kinase kinase kinase 7 TAK1/TAK1 Hs Inhibitor Inhibition 8.0 12.0 -0.5
C-terminal Src kinase CSK/CSK Hs Inhibitor Inhibition 8.0 29.0 3.5
serine/threonine kinase 39 nd/STK39(STLK3) Hs Inhibitor Inhibition 8.0
cyclin dependent kinase 3 CDK3-cyclin E/CDK3-cyclin E Hs Inhibitor Inhibition 8.2 1.5 2.0
mitogen-activated protein kinase kinase 2 nd/MEK2 Hs Inhibitor Inhibition 8.4
cyclin dependent kinase 2 CDK2/cyclin E Hs Inhibitor Inhibition 8.5
serum/glucocorticoid regulated kinase 1 SGK/SGK1 Hs Inhibitor Inhibition 8.6 5.5 1.0
KIT proto-oncogene, receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 8.7 9.5 1.0
cyclin dependent kinase 9 nd/CDK9 cyclin K Hs Inhibitor Inhibition 9.2
EPH receptor A5 EphA5/EPHA5 Hs Inhibitor Inhibition 9.3 8.0 1.5
Serine/threonine kinase 38 nd/STK38(NDR1) Hs Inhibitor Inhibition 10.0
cyclin dependent kinase 1 CDK1-cyclin B/CDK1-cyclin B Hs Inhibitor Inhibition 10.2 0.5 -0.5
Pim-2 proto-oncogene, serine/threonine kinase Pim-2/PIM2 Hs Inhibitor Inhibition 10.4 7.0 0.0
serine/threonine kinase 33 STK33/STK33 Hs Inhibitor Inhibition 10.7 1.0 -1.0
doublecortin like kinase 2 DCAMKL2/DCAMKL2 Hs Inhibitor Inhibition 11.0 5.5 2.5
EPH receptor A7 EphA7/EPHA7 Hs Inhibitor Inhibition 11.5 20.5 2.0
cyclin dependent kinase 6 nd/CDK6-cyclin D3 Hs Inhibitor Inhibition 11.7
CDC like kinase 1 nd/CLK1 Hs Inhibitor Inhibition 11.9
EPH receptor B1 EphB1/EPHB1 Hs Inhibitor Inhibition 12.0 18.5 -0.5
muscle associated receptor tyrosine kinase MuSK/MUSK Hs Inhibitor Inhibition 12.2 -1.0 0.5
AXL receptor tyrosine kinase Axl/AXL Hs Inhibitor Inhibition 13.3 3.0 0.0
EPH receptor A3 EphA3/EPHA3 Hs Inhibitor Inhibition 14.0 2.5 0.5
oxidative stress responsive kinase 1 nd/OSR1(OXSR1) Hs Inhibitor Inhibition 14.2
Insulin-like growth factor I receptor IGF-1R/IGF1R Hs Inhibitor Inhibition 14.8 92.5 6.5
mitogen-activated protein kinase kinase 6 MKK6/MKK6 Hs Inhibitor Inhibition 15.2 1.0 -1.5
cyclin dependent kinase 4 nd/CDK4/cyclin D3 Hs Inhibitor Inhibition 16.0
SRSF protein kinase 1 SRPK1/SRPK1 Hs Inhibitor Inhibition 17.8 9.0 -3.5
serine/threonine kinase 11 LKB1/LKB1 Hs Inhibitor Inhibition 18.7 77.0 20.0
dual serine/threonine and tyrosine protein kinase nd/RIPK5 Hs Inhibitor Inhibition 18.7
MAPK interacting serine/threonine kinase 1 nd/MNK1 Hs Inhibitor Inhibition 20.3
NUAK family, SNF1-like kinase, 2 nd/SNARK(NUAK2) Hs Inhibitor Inhibition 20.4
G protein-coupled receptor kinase 4 nd/GRK4 Hs Inhibitor Inhibition 20.5
nemo like kinase NLK/NLK Hs Inhibitor Inhibition 20.5 28.0 8.0
G protein-coupled receptor kinase 5 GRK5/GRK5 Hs Inhibitor Inhibition 20.8 8.0 1.0
EPH receptor A2 EphA2/EPHA2 Hs Inhibitor Inhibition 21.3 25.0 2.0
protein kinase C zeta PKCζ/PKCzeta Hs Inhibitor Inhibition 22.0 18.5 5.0
TEK receptor tyrosine kinase Tie2/TIE2(TEK) Hs Inhibitor Inhibition 22.0 2.0 -2.0
ABL proto-oncogene 1, non-receptor tyrosine kinase Abl/ABL1 Hs Inhibitor Inhibition 23.0 19.5 1.5
serum/glucocorticoid regulated kinase family member 3 SGK3/SGK3 Hs Inhibitor Inhibition 23.5 41.0 6.5
EPH receptor A8 EphA8/EPHA8 Hs Inhibitor Inhibition 25.7 29.5 9.0
NIMA related kinase 9 nd/NEK9 Hs Inhibitor Inhibition 27.2
EPH receptor B2 EphB2/EPHB2 Hs Inhibitor Inhibition 27.6 21.5 0.0
PDZ binding kinase nd/PBK(TOPK) Hs Inhibitor Inhibition 27.8
EPH receptor A1 EphA1/EPHA1 Hs Inhibitor Inhibition 31.0 3.0 -2.0
dual specificity tyrosine phosphorylation regulated kinase 3 nd/DYRK3 Hs Inhibitor Inhibition 31.3
epidermal growth factor receptor EGFR/EGFR Hs Inhibitor Inhibition 32.5 52.5 17.0
protein tyrosine kinase 6 BRK/BRK Hs Inhibitor Inhibition 32.6 40.0 6.5
MET proto-oncogene, receptor tyrosine kinase Met/c-MET Hs Inhibitor Inhibition 32.7 4.0 1.0
calcium/calmodulin dependent protein kinase IV CaMKIV/CAMK4 Hs Inhibitor Inhibition 34.8 2.5 0.5
erb-b2 receptor tyrosine kinase 2 nd/ERBB2(HER2) Hs Inhibitor Inhibition 35.9
TTK protein kinase nd/TTK Hs Inhibitor Inhibition 36.3
polo like kinase 1 Plk1/PLK1 Hs Inhibitor Inhibition 36.9 48.5 6.5
NIMA related kinase 11 NEK11/NEK11 Hs Inhibitor Inhibition 37.0 43.0 7.5
EPH receptor B4 EphB4/EPHB4 Hs Inhibitor Inhibition 37.6 70.0 14.0
polo like kinase 3 Plk3/PLK3 Hs Inhibitor Inhibition 37.8 86.0 46.5
component of inhibitor of nuclear factor kappa B kinase complex IKKα/IKKA(CHUK) Hs Inhibitor Inhibition 40.3 5.5 1.0
MAPK activated protein kinase 2 MAPKAP-K2/MAPKAPK2 Hs Inhibitor Inhibition 40.4 8.0 -3.0
SRSF protein kinase 2 SRPK2/SRPK2 Hs Inhibitor Inhibition 40.9 54.0 12.0
cyclin dependent kinase 7 CDK7-cyclin H-MAT1/CDK7-cyclin H Hs Inhibitor Inhibition 43.8 4.0 0.5
macrophage stimulating 1 receptor Ron/RON(MSTR1) Hs Inhibitor Inhibition 44.7 14.0 2.0
MAPK activated protein kinase 5 PRAK/MAPKAPK5(PRAK) Hs Inhibitor Inhibition 46.0 21.5 -0.5
NIMA related kinase 4 nd/NEK4 Hs Inhibitor Inhibition 46.8
receptor interacting serine/threonine kinase 2 RIPK2/RIPK2 Hs Inhibitor Inhibition 47.0 43.0 14.5
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 47.2 49.0 15.0
serine/threonine kinase 16 nd/STK16 Hs Inhibitor Inhibition 48.4
erb-b2 receptor tyrosine kinase 4 ErbB4/ERBB4(HER4) Hs Inhibitor Inhibition 48.8 57.0 14.5
beta adrenergic receptor kinase 2 nd/GRK3 Hs Inhibitor Inhibition 50.3
inhibitor of nuclear factor kappa B kinase subunit beta IKKβ/IKKb(IKBKB) Hs Inhibitor Inhibition 53.4 38.5 12.0
homeodomain interacting protein kinase 4 nd/HIPK1 Hs Inhibitor Inhibition 55.3
beta adrenergic receptor kinase 1 nd/GRK2 Hs Inhibitor Inhibition 56.8
casein kinase 2, alpha prime polypeptide subunit CK2α2/CK2a2 Hs Inhibitor Inhibition 66.6 84.0 76.0
dual specificity tyrosine phosphorylation regulated kinase 2 DYRK2/DYRK2 Hs Inhibitor Inhibition 69.9 64.5 18.0
WEE1 G2 checkpoint kinase nd/WEE1 Hs Inhibitor Inhibition 73.1
WNK lysine deficient protein kinase 3 WNK3/WNK3 Hs Inhibitor Inhibition 73.6 83.5 40.0
megakaryocyte-associated tyrosine kinase nd/CTK(MATK) Hs Inhibitor Inhibition 75.0
EPH receptor B3 EphB3/EPHB3 Hs Inhibitor Inhibition 75.2 97.0 119.5
casein kinase 1 gamma 2 CK1γ2/CK1g2 Hs Inhibitor Inhibition 75.7 81.5 40.5
casein kinase 1 epsilon nd/CK1epsilon Hs Inhibitor Inhibition 78.2
SRSF protein kinase 3 MSSK1/MSSK1(STK23) Hs Inhibitor Inhibition 79.6 90.0 45.5
casein kinase 1 alpha 1 nd/CK1a1 Hs Inhibitor Inhibition 79.7
NIMA related kinase 2 NEK2/NEK2 Hs Inhibitor Inhibition 79.9 63.5 29.5
activin A receptor type IL nd/ALK1(ACVRL1) Hs Inhibitor Inhibition 83.7
VRK serine/threonine kinase 1 nd/VRK1 Hs Inhibitor Inhibition 84.1
homeodomain interacting protein kinase 2 HIPK2/HIPK2 Hs Inhibitor Inhibition 84.7 49.5 11.5
MAPK activated protein kinase 3 MAPKAP-K3/MAPKAPK3 Hs Inhibitor Inhibition 85.1 97.0 44.5
CDC like kinase 3 CLK3/CLK3 Hs Inhibitor Inhibition 86.0 55.0 9.5
mitogen-activated protein kinase 13 SAPK4/P38d(MAPK13) Hs Inhibitor Inhibition 86.6 21.5 3.5
casein kinase 2, alpha 1 polypeptide subunit CK2/CK2a Hs Inhibitor Inhibition 87.9 85.5 90.0
NIMA related kinase 6 NEK6/NEK6 Hs Inhibitor Inhibition 88.6 92.0 88.0
tec protein tyrosine kinase nd/TEC Hs Inhibitor Inhibition 91.1
casein kinase 1 delta CK1δ/CK1d Hs Inhibitor Inhibition 91.2 81.5 49.0
casein kinase 1 gamma 1 CK1γ1/CK1g1 Hs Inhibitor Inhibition 91.4 101.5 55.0
activin A receptor type 1 nd/ALK2(ACVR1) Hs Inhibitor Inhibition 91.9
NIMA related kinase 3 NEK3/NEK3 Hs Inhibitor Inhibition 91.9 94.0 74.0
WNK lysine deficient protein kinase 2 WNK2/WNK2 Hs Inhibitor Inhibition 93.1 87.5 33.5
polo like kinase 2 Snk/PLK2 Hs Inhibitor Inhibition 94.8 66.5 30.5
NIMA related kinase 7 NEK7/NEK7 Hs Inhibitor Inhibition 95.8 106.0 113.0
casein kinase 1 gamma 3 CK1γ3/CK1g3 Hs Inhibitor Inhibition 96.1 93.0 55.0
dual specificity tyrosine phosphorylation regulated kinase 4 nd/DYRK4 Hs Inhibitor Inhibition 96.2
homeodomain interacting protein kinase 1 HIPK1/HIPK1 Hs Inhibitor Inhibition 96.5 90.5 57.0
mitogen-activated protein kinase 3 MAPK1/ERK1 Hs Inhibitor Inhibition 97.2 64.0 16.0
mitogen-activated protein kinase 1 MAPK2/ERK2(MAPK1) Hs Inhibitor Inhibition 97.4 71.5 38.5
ZAK sterile alpha motif and leucine zipper containing kinase AZK nd/ZAK(MLTK) Hs Inhibitor Inhibition 98.3
mitogen-activated protein kinase 11 SAPK2b/P38b(MAPK11) Hs Inhibitor Inhibition 98.8 101.0 91.0
mitogen-activated protein kinase 9 JNK2α2/JNK2 Hs Inhibitor Inhibition 100.0 59.5 27.0
homeodomain interacting protein kinase 3 HIPK3/HIPK3 Hs Inhibitor Inhibition 100.7 78.0 30.5
mitogen-activated protein kinase 14 SAPK2a/P38a(MAPK14) Hs Inhibitor Inhibition 101.0 85.0 81.5
mitogen-activated protein kinase 8 JNK1α1/JNK1 Hs Inhibitor Inhibition 102.5 56.0 12.0
mitogen-activated protein kinase kinase kinase 8 nd/COT1(MAP3K8) Hs Inhibitor Inhibition 106.0
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites nd/SRMS Hs Inhibitor Inhibition 111.0
B-Raf proto-oncogene, serine/threonine kinase nd/BRAF Hs Inhibitor Inhibition 112.8
transforming growth factor beta receptor 1 TGFBR1/ALK5(TGFBR1) Hs Inhibitor Inhibition 114.2 83.0 31.0
mitogen-activated protein kinase 12 SAPK3/P38g Hs Inhibitor Inhibition 116.7 35.0 8.0
mitogen-activated protein kinase kinase kinase 14 nd/NIK(MAP3K14) Hs Inhibitor Inhibition 117.2
activin A receptor type 1B nd/ALK4(ACVR1B) Hs Inhibitor Inhibition 117.3 59.5 12.5
Raf-1 proto-oncogene, serine/threonine kinase c-RAF/RAF1 Hs Inhibitor Inhibition 119.5 98.0 89.5
mitogen-activated protein kinase 10 JNK3/JNK3 Hs Inhibitor Inhibition 123.2 15.5 3.0
transforming growth factor beta receptor 2 nd/TGFBR2 Hs Inhibitor Inhibition 132.6
A-Raf proto-oncogene, serine/threonine kinase nd/ARAF Hs Inhibitor Inhibition 134.4
protein kinase AMP-activated catalytic subunit alpha 2 AMPKα2/nd Hs Inhibitor Inhibition -2.5 1.0
LCK proto-oncogene, Src family tyrosine kinase Lck activated Hs Inhibitor Inhibition -1.5 0.0
protein kinase AMP-activated catalytic subunit alpha 1 AMPKα1/nd Hs Inhibitor Inhibition -0.5 0.0
HCK proto-oncogene, Src family tyrosine kinase Hck (activated)/nd Hs Inhibitor Inhibition 1.0 3.0
salt inducible kinase 1 SIK/nd Hs Inhibitor Inhibition 1.0 0.0
cyclin dependent kinase 2 CDK2/cyclinE Hs Inhibitor Inhibition 1.0 -0.5
Insulin receptor IR (activated)/nd Hs Inhibitor Inhibition 5.5 0.5
mitogen-activated protein kinase kinase 7 MKK7β/nd Hs Inhibitor Inhibition 11.0 1.5
Insulin-like growth factor I receptor IGF-1R (activated)/nd Hs Inhibitor Inhibition 14.5 4.0
tec protein tyrosine kinase Tec (activated)/nd Hs Inhibitor Inhibition 17.0 2.5
eukaryotic elongation factor 2 kinase eEF-2K/nd Hs Inhibitor Inhibition 85.0 119.0
mechanistic target of rapamycin kinase mTOR/nd Hs Inhibitor Inhibition 95.5 88.5
mechanistic target of rapamycin kinase mTOR-FKBP12/nd Hs Inhibitor Inhibition 103.0 84.0
VRK serine/threonine kinase 2 VRK2/nd Hs Inhibitor Inhibition 103.5 87.5

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]

2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]