VEGF receptor tyrosine kinase inhibitor II

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx

Reference: 1-2
Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 18.4 1.0 0.0
fms related receptor tyrosine kinase 1 Flt1/FLT1(VEGFR1) Hs Inhibitor Inhibition 24.8 0.0 2.0
kinase insert domain receptor KDR/KDR(VEGFR2) Hs Inhibitor Inhibition 28.2 3.0 4.0
KIT proto-oncogene, receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 33.6 17.0 -1.0
fms related receptor tyrosine kinase 4 Flt4/FLT4 Hs Inhibitor Inhibition 44.8 0.0 0.0
platelet derived growth factor receptor beta PDGFRβ/PDGFRb Hs Inhibitor Inhibition 45.0 46.0 4.0
ret proto-oncogene Ret/RET Hs Inhibitor Inhibition 58.9 53.0 6.0
Raf-1 proto-oncogene, serine/threonine kinase c-RAF/RAF1 Hs Inhibitor Inhibition 62.6 41.0 9.0
fyn related Src family tyrosine kinase PTK5/FRK(PTK5) Hs Inhibitor Inhibition 62.8 19.0 1.0
protein tyrosine kinase 6 BRK/BRK Hs Inhibitor Inhibition 63.6 21.0 1.0
erb-b2 receptor tyrosine kinase 4 ErbB4/ERBB4(HER4) Hs Inhibitor Inhibition 71.3 95.0 111.0
LYN proto-oncogene, Src family tyrosine kinase Lyn/LYN Hs Inhibitor Inhibition 75.1 30.0 2.0
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 77.7 100.0 37.0
MER proto-oncogene, tyrosine kinase Mer/c-MER Hs Inhibitor Inhibition 79.0 101.0 99.0
p21 (RAC1) activated kinase 5 PAK5/PAK5 Hs Inhibitor Inhibition 79.4 117.0 128.0
CDC42 binding protein kinase beta MRCKβ/MRCKb(CDC42BPB) Hs Inhibitor Inhibition 79.9 89.0 90.0
glycogen synthase kinase 3 alpha GSK3α/GSK3a Hs Inhibitor Inhibition 80.1 118.0 130.0
FER tyrosine kinase Fer/FER Hs Inhibitor Inhibition 80.4 131.0 101.0
platelet derived growth factor receptor alpha PDGFRα/PDGFRa Hs Inhibitor Inhibition 81.3 39.0 7.0
serine/threonine kinase 10 LOK/LOK(STK10) Hs Inhibitor Inhibition 81.8 82.0 64.0
cyclin dependent kinase 9 CDK9-cyclin T1/CDK9-cyclin T1 Hs Inhibitor Inhibition 81.9 118.0 83.0
myosin IIIB nd/MYO3b Hs Inhibitor Inhibition 82.0
EPH receptor A5 EphA5/EPHA5 Hs Inhibitor Inhibition 82.1 90.0 78.0
MAPK interacting serine/threonine kinase 2 Mnk2/MNK2 Hs Inhibitor Inhibition 82.3 112.0 96.0
receptor interacting serine/threonine kinase 2 RIPK2/RIPK2 Hs Inhibitor Inhibition 82.9 104.0 78.0
LIM domain kinase 1 LIMK1/LIMK1 Hs Inhibitor Inhibition 83.4 113.0 85.0
fibroblast growth factor receptor 1 FGFR1/FGFR1 Hs Inhibitor Inhibition 83.7 75.0 10.0
FGR proto-oncogene, Src family tyrosine kinase Fgr/FGR Hs Inhibitor Inhibition 83.8 90.0 88.0
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 84.1 105.0 78.0
aurora kinase A Aurora-A/Aurora A Hs Inhibitor Inhibition 84.4 39.0 18.0
protein kinase C delta PKCδ/PKCd Hs Inhibitor Inhibition 84.7 106.0 114.0
unc-51 like kinase 3 ULK3/ULK3 Hs Inhibitor Inhibition 84.7 114.0 91.0
EPH receptor B2 EphB2/EPHB2 Hs Inhibitor Inhibition 84.7 114.0 97.0
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 84.9 107.0 111.0
SRSF protein kinase 2 SRPK2/SRPK2 Hs Inhibitor Inhibition 85.1 98.0 95.0
NIMA related kinase 4 nd/NEK4 Hs Inhibitor Inhibition 85.8
ZAK sterile alpha motif and leucine zipper containing kinase AZK nd/ZAK(MLTK) Hs Inhibitor Inhibition 86.0
testis specific serine kinase 2 TSSK2/TSSK2 Hs Inhibitor Inhibition 86.3 87.0 116.0
serine/threonine kinase 33 STK33/STK33 Hs Inhibitor Inhibition 86.4 89.0 101.0
cyclin dependent kinase 6 nd/CDK6-cyclin D3 Hs Inhibitor Inhibition 86.5
STE20 like kinase nd/SLK(STK2) Hs Inhibitor Inhibition 86.6
Protein kinase G (PKG) 1 PKG1α/PKG1a Hs Inhibitor Inhibition 86.8 100.0 94.0
unc-51 like autophagy activating kinase 1 nd/ULK1 Hs Inhibitor Inhibition 86.9
nemo like kinase NLK/NLK Hs Inhibitor Inhibition 87.2 100.0 93.0
cyclin dependent kinase 3 CDK3-cyclin E/CDK3-cyclin E Hs Inhibitor Inhibition 87.4 109.0 98.0
protein kinase, cAMP-dependent, catalytic, gamma subunit nd/PKAcg Hs Inhibitor Inhibition 87.4
EPH receptor A8 EphA8/EPHA8 Hs Inhibitor Inhibition 87.6 92.0 98.0
Janus kinase 3 JAK3/JAK3 Hs Inhibitor Inhibition 87.8 101.0 114.0
Insulin receptor IR/IR Hs Inhibitor Inhibition 88.0 100.0 79.0
casein kinase 1 alpha 1 nd/CK1a1 Hs Inhibitor Inhibition 88.1
casein kinase 1 gamma 2 CK1γ2/CK1g2 Hs Inhibitor Inhibition 88.3 88.0 87.0
TANK binding kinase 1 TBK1/TBK1 Hs Inhibitor Inhibition 88.4 103.0 90.0
NIMA related kinase 2 NEK2/NEK2 Hs Inhibitor Inhibition 88.4 86.0 115.0
PDZ binding kinase nd/PBK(TOPK) Hs Inhibitor Inhibition 88.5
MAPK activated protein kinase 5 PRAK/MAPKAPK5(PRAK) Hs Inhibitor Inhibition 88.7 60.0 51.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 88.7
SRC proto-oncogene, non-receptor tyrosine kinase cSrc/c-SRC Hs Inhibitor Inhibition 88.8 78.0 88.0
discoidin domain receptor tyrosine kinase 2 DDR2/DDR2 Hs Inhibitor Inhibition 88.9 88.0 36.0
mitogen-activated protein kinase kinase kinase 9 MLK1/MLK19MAP3K90 Hs Inhibitor Inhibition 89.0 99.0 112.0
mitogen-activated protein kinase kinase kinase 11 nd/MLK3(MAP3K11) Hs Inhibitor Inhibition 89.0
calcium/calmodulin-dependent protein kinase II gamma subunit CaMKIIγ/CAMK2g Hs Inhibitor Inhibition 89.2 103.0 92.0
protein tyrosine kinase 2 beta Pyk2/PYK2 Hs Inhibitor Inhibition 89.3 128.0 74.0
glycogen synthase kinase 3 beta GSK3β/GSK3b Hs Inhibitor Inhibition 89.3 92.0 99.0
EPH receptor B4 EphB4/EPHB4 Hs Inhibitor Inhibition 89.6 117.0 131.0
EPH receptor A6 nd/EPHA6 Hs Inhibitor Inhibition 89.8
mitogen-activated protein kinase 10 JNK3/JNK3 Hs Inhibitor Inhibition 89.9 72.0 123.0
B-Raf proto-oncogene, serine/threonine kinase nd/BRAF Hs Inhibitor Inhibition 90.0
transforming growth factor beta receptor 2 nd/TGFBR2 Hs Inhibitor Inhibition 90.1
WEE1 G2 checkpoint kinase nd/WEE1 Hs Inhibitor Inhibition 90.1
ribosomal protein S6 kinase A4 MSK2/MSK2(RPS6KA4) Hs Inhibitor Inhibition 90.2 87.0 101.0
EPH receptor B1 EphB1/EPHB1 Hs Inhibitor Inhibition 90.2 112.0 104.0
cyclin dependent kinase 5 CDK5-p35/CDK5-p35 Hs Inhibitor Inhibition 90.4 99.0 104.0
BMX non-receptor tyrosine kinase Bmx/BMX(ETK) Hs Inhibitor Inhibition 90.5 99.0 102.0
macrophage stimulating 1 receptor Ron/RON(MSTR1) Hs Inhibitor Inhibition 90.5 103.0 86.0
NIMA related kinase 3 NEK3/NEK3 Hs Inhibitor Inhibition 90.5 106.0 115.0
CDC42 binding protein kinase alpha MRCKα/MRCKa(CDC42BPA) Hs Inhibitor Inhibition 90.5 104.0 107.0
protein kinase X-linked PrKX/PRKX Hs Inhibitor Inhibition 90.5 95.0 50.0
p21 (RAC1) activated kinase 4 PAK4/PAK4 Hs Inhibitor Inhibition 90.6 100.0 99.0
serine/threonine-protein kinase MST4 nd/MSTR4 Hs Inhibitor Inhibition 90.9
p21 (RAC1) activated kinase 2 PAK2/PAK2 Hs Inhibitor Inhibition 91.0 112.0 97.0
casein kinase 2, alpha 1 polypeptide subunit CK2/CK2a Hs Inhibitor Inhibition 91.1 105.0 102.0
epidermal growth factor receptor EGFR/EGFR Hs Inhibitor Inhibition 91.2 109.0 91.0
NIMA related kinase 9 nd/NEK9 Hs Inhibitor Inhibition 91.2
ribosomal protein S6 kinase A3 Rsk2/RSK2 Hs Inhibitor Inhibition 91.4 116.0 97.0
mitogen-activated protein kinase 11 SAPK2b/P38b(MAPK11) Hs Inhibitor Inhibition 91.4 91.0 84.0
A-Raf proto-oncogene, serine/threonine kinase nd/ARAF Hs Inhibitor Inhibition 91.4
MAPK activated protein kinase 3 MAPKAP-K3/MAPKAPK3 Hs Inhibitor Inhibition 91.4 96.0 94.0
fms related receptor tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 91.5 94.0 65.0
serine/threonine kinase 25 nd/STK25(YSK1) Hs Inhibitor Inhibition 91.6
CDC like kinase 2 CLK2/CLK2 Hs Inhibitor Inhibition 91.8 120.0 99.0
cyclin dependent kinase 1 nd/CDK1-cyclin A Hs Inhibitor Inhibition 91.8
Janus kinase 1 nd/JAK1 Hs Inhibitor Inhibition 91.8
ribosomal protein S6 kinase A1 Rsk1/RSK1 Hs Inhibitor Inhibition 92.0 129.0 85.0
protein kinase D3 nd/PKCnu(PRKD3) Hs Inhibitor Inhibition 92.1
EPH receptor A3 EphA3/EPHA3 Hs Inhibitor Inhibition 92.1 113.0 103.0
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 92.1
cyclin dependent kinase 2 CDK2-cyclin A/CDK2-cyclin A Hs Inhibitor Inhibition 92.2 126.0 86.0
MET proto-oncogene, receptor tyrosine kinase Met/c-MET Hs Inhibitor Inhibition 92.2 91.0 91.0
fibroblast growth factor receptor 3 FGFR3/FGFR3 Hs Inhibitor Inhibition 92.2 105.0 73.0
Protein kinase G (PKG) 1 PKG1β/PKG1b Hs Inhibitor Inhibition 92.3 114.0 112.0
maternal embryonic leucine zipper kinase MELK/MELK Hs Inhibitor Inhibition 92.3 75.0 86.0
TEK receptor tyrosine kinase Tie2/TIE2(TEK) Hs Inhibitor Inhibition 92.4 112.0 79.0
serum/glucocorticoid regulated kinase family member 3 SGK3/SGK3 Hs Inhibitor Inhibition 92.5 93.0 94.0
casein kinase 1 epsilon nd/CK1epsilon Hs Inhibitor Inhibition 92.5
ribosomal protein S6 kinase A5 MSK1/MSK1(RPS6KA5) Hs Inhibitor Inhibition 92.5 102.0 89.0
ribosomal protein S6 kinase B1 p70S6K/p70S6K(RPS6KB1) Hs Inhibitor Inhibition 92.5 135.0 111.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 92.6 72.0 77.0
homeodomain interacting protein kinase 1 HIPK1/HIPK1 Hs Inhibitor Inhibition 92.7 95.0 101.0
microtubule affinity regulating kinase 2 PAR-1Bα/MARK2(PAR-1Ba) Hs Inhibitor Inhibition 92.7 100.0 105.0
mitogen-activated protein kinase kinase kinase 2 nd/MEKK2 Hs Inhibitor Inhibition 92.8
WNK lysine deficient protein kinase 3 WNK3/WNK3 Hs Inhibitor Inhibition 92.9 97.0 97.0
homeodomain interacting protein kinase 2 HIPK2/HIPK2 Hs Inhibitor Inhibition 93.0 98.0 104.0
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 93.0 106.0 103.0
microtubule affinity regulating kinase 3 nd/MARK3 Hs Inhibitor Inhibition 93.1
protein kinase N2 PRK2/PKN2(PRK2) Hs Inhibitor Inhibition 93.2 91.0 125.0
protein kinase D1 PKCμ/PKCmu(PRKD1) Hs Inhibitor Inhibition 93.2 89.0 95.0
LCK proto-oncogene, Src family tyrosine kinase Lck/LCK Hs Inhibitor Inhibition 93.3 95.0 74.0
protein kinase C beta PKCβII/PKCb2 Hs Inhibitor Inhibition 93.3 102.0 107.0
ABL proto-oncogene 2, non-receptor tyrosine kinase Arg/ABL2(ARG) Hs Inhibitor Inhibition 93.4 110.0 84.0
cyclin dependent kinase 6 CDK6-cyclin D3/CDK6-cyclin D1 Hs Inhibitor Inhibition 93.4 102.0 102.0
aurora kinase C Aurora-C/Aurora C Hs Inhibitor Inhibition 93.4 105.0 70.0
calcium/calmodulin-dependent protein kinase II beta subunit CaMKIIβ/CAMK2b Hs Inhibitor Inhibition 93.4 99.0 83.0
serine/threonine kinase 11 LKB1/LKB1 Hs Inhibitor Inhibition 93.5 101.0 99.0
spleen associated tyrosine kinase Syk/SYK Hs Inhibitor Inhibition 93.6 126.0 97.0
LYN proto-oncogene, Src family tyrosine kinase nd/LYN B Hs Inhibitor Inhibition 93.7
Rho associated coiled-coil containing protein kinase 2 ROCK-II/ROCK2 Hs Inhibitor Inhibition 93.8 108.0 87.0
calcium/calmodulin dependent protein kinase kinase 2 nd/CAMKK2 Hs Inhibitor Inhibition 93.9
BR serine/threonine kinase 1 BrSK1/BRSK1 Hs Inhibitor Inhibition 94.0 86.0 126.0
death associated protein kinase 3 ZIPK/ZIPK(DAPK3) Hs Inhibitor Inhibition 94.0 97.0 111.0
TAO kinase 3 TAO3/TAOK3(JIK) Hs Inhibitor Inhibition 94.1 98.0 85.0
ribosomal protein S6 kinase A2 Rsk3/RSK3 Hs Inhibitor Inhibition 94.1 108.0 105.0
IL2 inducible T cell kinase Itk/ITK Hs Inhibitor Inhibition 94.1 109.0 108.0
serine/threonine kinase 16 nd/STK16 Hs Inhibitor Inhibition 94.1
phosphorylase kinase catalytic subunit gamma 1 nd/PHKg1 Hs Inhibitor Inhibition 94.2
cyclin dependent kinase 4 nd/CDK4/cyclin D3 Hs Inhibitor Inhibition 94.2
serine/threonine kinase 3 MST2/MST2(STK3) Hs Inhibitor Inhibition 94.2 89.0 85.0
cyclin dependent kinase 2 CDK2/cyclin E Hs Inhibitor Inhibition 94.3
checkpoint kinase 2 CHK2/CHK2 Hs Inhibitor Inhibition 94.5 91.0 89.0
serine/threonine kinase 17a DRAK1/DRAK1(STK17A) Hs Inhibitor Inhibition 94.7 99.0 99.0
microtubule affinity regulating kinase 1 MARK1/MARK1 Hs Inhibitor Inhibition 94.7 93.0 87.0
dual serine/threonine and tyrosine protein kinase nd/RIPK5 Hs Inhibitor Inhibition 94.7
mitogen-activated protein kinase 1 MAPK2/ERK2(MAPK1) Hs Inhibitor Inhibition 94.7 108.0 109.0
serine/threonine kinase 39 nd/STK39(STLK3) Hs Inhibitor Inhibition 94.7
salt inducible kinase 2 nd/SIK2 Hs Inhibitor Inhibition 94.8
pregnancy up-regulated nonubiquitous CaM kinase nd/CAMK1b Hs Inhibitor Inhibition 94.8
p21 (RAC1) activated kinase 1 nd/PAK1 Hs Inhibitor Inhibition 94.9
EPH receptor A7 EphA7/EPHA7 Hs Inhibitor Inhibition 95.0 98.0 89.0
cyclin dependent kinase 7 CDK7-cyclin H-MAT1/CDK7-cyclin H Hs Inhibitor Inhibition 95.1 87.0 124.0
AKT serine/threonine kinase 2 PKBβ/AKT2 Hs Inhibitor Inhibition 95.2 140.0 107.0
protein kinase N1 nd/PKN1(PRK1) Hs Inhibitor Inhibition 95.2
doublecortin like kinase 2 DCAMKL2/DCAMKL2 Hs Inhibitor Inhibition 95.2 74.0 113.0
calcium/calmodulin dependent protein kinase ID CaMKIδ/CAMK1d Hs Inhibitor Inhibition 95.3 132.0 116.0
3-phosphoinositide dependent protein kinase 1 PDK1/PDK1(PDPK1) Hs Inhibitor Inhibition 95.3 107.0 106.0
YES proto-oncogene 1, Src family tyrosine kinase Tes/YES(YES1) Hs Inhibitor Inhibition 95.3 117.0 75.0
histone H3 associated protein kinase Haspin/Haspin Hs Inhibitor Inhibition 95.5 135.0 97.0
neurotrophic receptor tyrosine kinase 1 TrkA/TRKA Hs Inhibitor Inhibition 95.5 85.0 80.0
p21 (RAC1) activated kinase 3 PAK3/PAK3 Hs Inhibitor Inhibition 95.5 99.0 101.0
cyclin dependent kinase 9 nd/CDK9 cyclin K Hs Inhibitor Inhibition 95.5
mitogen-activated protein kinase 13 SAPK4/P38d(MAPK13) Hs Inhibitor Inhibition 95.6 108.0 98.0
protein tyrosine kinase 2 FAK/FAK(PTK2) Hs Inhibitor Inhibition 95.7 143.0 73.0
fibroblast growth factor receptor 2 FGFR2/FGFR2 Hs Inhibitor Inhibition 95.7 96.0 47.0
mitogen-activated protein kinase kinase kinase kinase 5 nd/KHS(MAP4K5) Hs Inhibitor Inhibition 95.8
activin A receptor type 1B nd/ALK4(ACVR1B) Hs Inhibitor Inhibition 95.8 130.0 72.0
muscle associated receptor tyrosine kinase MuSK/MUSK Hs Inhibitor Inhibition 95.9 109.0 63.0
serum/glucocorticoid regulated kinase 1 SGK/SGK1 Hs Inhibitor Inhibition 96.0 107.0 128.0
NIMA related kinase 1 nd/NEK1 Hs Inhibitor Inhibition 96.0
Insulin-like growth factor I receptor IGF-1R/IGF1R Hs Inhibitor Inhibition 96.0 125.0 111.0
dual specificity tyrosine phosphorylation regulated kinase 2 DYRK2/DYRK2 Hs Inhibitor Inhibition 96.0 105.0 100.0
beta adrenergic receptor kinase 2 nd/GRK3 Hs Inhibitor Inhibition 96.1
Insulin receptor-related receptor IRR/IRR(INSRR) Hs Inhibitor Inhibition 96.1 110.0 61.0
protein kinase C eta PKCη/PKCeta Hs Inhibitor Inhibition 96.2 97.0 75.0
G protein-coupled receptor kinase 7 GRK7/GRK7 Hs Inhibitor Inhibition 96.2 109.0 94.0
mitogen-activated protein kinase kinase kinase 3 nd/MEKK3 Hs Inhibitor Inhibition 96.2
cyclin dependent kinase 1 CDK1-cyclin B/CDK1-cyclin B Hs Inhibitor Inhibition 96.3 104.0 90.0
checkpoint kinase 1 CHK1/CHK1 Hs Inhibitor Inhibition 96.4 89.0 110.0
Janus kinase 2 JAK2/JAK2 Hs Inhibitor Inhibition 96.5 129.0 74.0
EPH receptor A4 EphA4/EPHA4 Hs Inhibitor Inhibition 96.5 106.0 99.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 96.5 99.0 84.0
FES proto-oncogene, tyrosine kinase Fes/FES Hs Inhibitor Inhibition 96.6 115.0 87.0
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 96.7 104.0 101.0
mitogen-activated protein kinase kinase 1 MEK1/MEK1 Hs Inhibitor Inhibition 96.8 103.0 108.0
oxidative stress responsive kinase 1 nd/OSR1(OXSR1) Hs Inhibitor Inhibition 96.8
G protein-coupled receptor kinase 4 nd/GRK4 Hs Inhibitor Inhibition 96.8
misshapen like kinase 1 MINK/MINK(MINK1) Hs Inhibitor Inhibition 96.9 92.0 108.0
EPH receptor B3 EphB3/EPHB3 Hs Inhibitor Inhibition 96.9 113.0 125.0
neurotrophic receptor tyrosine kinase 3 nd/TRKC Hs Inhibitor Inhibition 97.0
FYN proto-oncogene, Src family tyrosine kinase Fyn/FYN Hs Inhibitor Inhibition 97.0 102.0 70.0
EPH receptor A1 EphA1/EPHA1 Hs Inhibitor Inhibition 97.0 89.0 102.0
protein kinase C epsilon PKCε/PKCepsilon Hs Inhibitor Inhibition 97.0 85.0 90.0
PAS domain containing serine/threonine kinase PASK/PASK Hs Inhibitor Inhibition 97.1 104.0 92.0
phosphorylase kinase catalytic subunit gamma 2 PhKγ2/PHKg2 Hs Inhibitor Inhibition 97.1 87.0 113.0
dual specificity tyrosine phosphorylation regulated kinase 1A nd/DYRK1(DYRK1A) Hs Inhibitor Inhibition 97.1
NIMA related kinase 6 NEK6/NEK6 Hs Inhibitor Inhibition 97.1 105.0 109.0
protein kinase, cAMP-dependent, catalytic, alpha subunit PKA/PKA Hs Inhibitor Inhibition 97.1 93.0 83.0
activin A receptor type 1 nd/ALK2(ACVR1) Hs Inhibitor Inhibition 97.2
tousled like kinase 2 TLK2/TLK2 Hs Inhibitor Inhibition 97.3 109.0 94.0
G protein-coupled receptor kinase 5 GRK5/GRK5 Hs Inhibitor Inhibition 97.3 112.0 103.0
mitogen-activated protein kinase kinase kinase kinase 2 GCK/GCK(MAP4K2) Hs Inhibitor Inhibition 97.3 92.0 58.0
mitogen-activated protein kinase 12 SAPK3/P38g Hs Inhibitor Inhibition 97.3 100.0 97.0
Serine/threonine kinase 38 nd/STK38(NDR1) Hs Inhibitor Inhibition 97.5
MAPK activated protein kinase 2 MAPKAP-K2/MAPKAPK2 Hs Inhibitor Inhibition 97.6 81.0 114.0
AKT serine/threonine kinase 1 PKBα/AKT1 Hs Inhibitor Inhibition 97.6 93.0 106.0
TXK tyrosine kinase Txk/TXK Hs Inhibitor Inhibition 97.7 88.0 78.0
AKT serine/threonine kinase 3 PKBγ/AKT3 Hs Inhibitor Inhibition 97.9 109.0 100.0
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites nd/SRMS Hs Inhibitor Inhibition 97.9
protein kinase D2 PKD2/PKD2(PRKD2) Hs Inhibitor Inhibition 98.0 99.0 110.0
protein kinase C beta PKCβI/PKCb1 Hs Inhibitor Inhibition 98.1 113.0 89.0
CDC like kinase 3 CLK3/CLK3 Hs Inhibitor Inhibition 98.1 83.0 119.0
AXL receptor tyrosine kinase Axl/AXL Hs Inhibitor Inhibition 98.1 86.0 82.0
casein kinase 1 delta CK1δ/CK1d Hs Inhibitor Inhibition 98.1 101.0 105.0
mitogen-activated protein kinase kinase kinase 7 TAK1/TAK1 Hs Inhibitor Inhibition 98.1 98.0 92.0
beta adrenergic receptor kinase 1 nd/GRK2 Hs Inhibitor Inhibition 98.2
casein kinase 2, alpha prime polypeptide subunit CK2α2/CK2a2 Hs Inhibitor Inhibition 98.3 123.0 96.0
death associated protein kinase 2 DAPK2/DAPK2 Hs Inhibitor Inhibition 98.4 85.0 119.0
Rho associated coiled-coil containing protein kinase 1 ROCK-I/ROCK1 Hs Inhibitor Inhibition 98.4 105.0 111.0
calcium/calmodulin dependent protein kinase kinase 1 nd/CAMKK1 Hs Inhibitor Inhibition 98.5
polo like kinase 3 Plk3/PLK3 Hs Inhibitor Inhibition 98.5 85.0 87.0
serine/threonine kinase 4 MST1/MST1(STK4) Hs Inhibitor Inhibition 98.7 93.0 112.0
erb-b2 receptor tyrosine kinase 2 nd/ERBB2(HER2) Hs Inhibitor Inhibition 98.7
protein kinase C iota PKCι/PKCiota Hs Inhibitor Inhibition 98.7 93.0 96.0
leucine rich repeat kinase 2 nd/LRRK2 Hs Inhibitor Inhibition 98.7
homeodomain interacting protein kinase 3 HIPK3/HIPK3 Hs Inhibitor Inhibition 98.7 100.0 109.0
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 98.9 84.0 102.0
activin A receptor type IL nd/ALK1(ACVRL1) Hs Inhibitor Inhibition 98.9
Bruton tyrosine kinase BTK/BTK Hs Inhibitor Inhibition 98.9 92.0 108.0
inhibitor of nuclear factor kappa B kinase subunit epsilon nd/IKKe(IKBKE) Hs Inhibitor Inhibition 98.9
Protein kinase G (PKG) 2 nd/PKG2(PRKG2) Hs Inhibitor Inhibition 99.1
polo like kinase 2 Snk/PLK2 Hs Inhibitor Inhibition 99.3 109.0 105.0
megakaryocyte-associated tyrosine kinase nd/CTK(MATK) Hs Inhibitor Inhibition 99.3
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 99.3 92.0 76.0
inhibitor of nuclear factor kappa B kinase subunit beta IKKβ/IKKb(IKBKB) Hs Inhibitor Inhibition 99.3 114.0 90.0
myosin light chain kinase 2 nd/MLCK2(MYLK2) Hs Inhibitor Inhibition 99.5
Pim-2 proto-oncogene, serine/threonine kinase Pim-2/PIM2 Hs Inhibitor Inhibition 99.5 132.0 124.0
ABL proto-oncogene 1, non-receptor tyrosine kinase Abl/ABL1 Hs Inhibitor Inhibition 99.7 81.0 52.0
calcium/calmodulin-dependent protein kinase II alpha subunit nd/CAMK2a Hs Inhibitor Inhibition 99.9
death associated protein kinase 1 DAPK1/DAPK1 Hs Inhibitor Inhibition 99.9 92.0 98.0
transforming growth factor beta receptor 1 TGFBR1/ALK5(TGFBR1) Hs Inhibitor Inhibition 100.0 92.0 106.0
SRSF protein kinase 3 MSSK1/MSSK1(STK23) Hs Inhibitor Inhibition 100.1 98.0 88.0
c-ros oncogene 1, receptor tyrosine kinase Ros/ROS(ROS1) Hs Inhibitor Inhibition 100.3 101.0 95.0
protein kinase C zeta PKCζ/PKCzeta Hs Inhibitor Inhibition 100.4 101.0 107.0
C-terminal Src kinase CSK/CSK Hs Inhibitor Inhibition 100.5 118.0 91.0
p21 (RAC1) activated kinase 6 PAK6/PAK6 Hs Inhibitor Inhibition 100.6 102.0 90.0
EPH receptor A2 EphA2/EPHA2 Hs Inhibitor Inhibition 100.6 84.0 81.0
WNK lysine deficient protein kinase 2 WNK2/WNK2 Hs Inhibitor Inhibition 100.6 112.0 91.0
calcium/calmodulin dependent protein kinase IV CaMKIV/CAMK4 Hs Inhibitor Inhibition 100.6 115.0 68.0
G protein-coupled receptor kinase 6 GRK6/GRK6 Hs Inhibitor Inhibition 100.8 103.0 91.0
calcium/calmodulin dependent protein kinase IG nd/CAMK1g Hs Inhibitor Inhibition 101.3
calcium/calmodulin-dependent protein kinase II delta subunit CaMKIIδ/CAMK2d Hs Inhibitor Inhibition 101.4 109.0 90.0
CDC like kinase 1 nd/CLK1 Hs Inhibitor Inhibition 101.5
BR serine/threonine kinase 2 BrSK2/BRSK2 Hs Inhibitor Inhibition 101.5 120.0 109.0
HCK proto-oncogene, Src family tyrosine kinase Hck/HCK Hs Inhibitor Inhibition 101.5 80.0 38.0
neurotrophic receptor tyrosine kinase 2 TrkB/TRKB Hs Inhibitor Inhibition 101.6 117.0 99.0
mitogen-activated protein kinase 9 JNK2α2/JNK2 Hs Inhibitor Inhibition 101.6 105.0 90.0
mitogen-activated protein kinase kinase 2 nd/MEK2 Hs Inhibitor Inhibition 101.7
protein kinase C gamma PKCγ/PKCg Hs Inhibitor Inhibition 101.7 110.0 108.0
mitogen-activated protein kinase 3 MAPK1/ERK1 Hs Inhibitor Inhibition 101.8 77.0 80.0
TTK protein kinase nd/TTK Hs Inhibitor Inhibition 101.9
TAO kinase 2 TAO2/TAOK2(TAO1) Hs Inhibitor Inhibition 102.0 101.0 61.0
BLK proto-oncogene, Src family tyrosine kinase Blk/BLK Hs Inhibitor Inhibition 102.3 115.0 94.0
NIMA related kinase 7 NEK7/NEK7 Hs Inhibitor Inhibition 102.6 94.0 120.0
polo like kinase 1 Plk1/PLK1 Hs Inhibitor Inhibition 102.8 110.0 79.0
testis specific serine kinase 1B TSSK1/STK22D(TSSK1) Hs Inhibitor Inhibition 102.8 98.0 90.0
homeodomain interacting protein kinase 4 nd/HIPK1 Hs Inhibitor Inhibition 103.0
serum/glucocorticoid regulated kinase 2 SGK2/SGK2 Hs Inhibitor Inhibition 103.1 88.0 72.0
calcium/calmodulin dependent protein kinase I CaMKI/CAMK1a Hs Inhibitor Inhibition 103.4 95.0 104.0
DM1 protein kinase DMPK/DMPK Hs Inhibitor Inhibition 103.4 89.0 120.0
zeta chain of T cell receptor associated protein kinase 70 ZAP-70/ZAP70 Hs Inhibitor Inhibition 103.4 113.0 142.0
ALK receptor tyrosine kinase ALK/ALK Hs Inhibitor Inhibition 103.5 91.0 123.0
dual specificity tyrosine phosphorylation regulated kinase 4 nd/DYRK4 Hs Inhibitor Inhibition 103.7
dual specificity tyrosine phosphorylation regulated kinase 3 nd/DYRK3 Hs Inhibitor Inhibition 103.8
cyclin dependent kinase 4 nd/CDK4/cyclin D1 Hs Inhibitor Inhibition 103.8
NIMA related kinase 11 NEK11/NEK11 Hs Inhibitor Inhibition 103.8 96.0 108.0
interleukin 1 receptor associated kinase 4 IRAK4/IRAK4 Hs Inhibitor Inhibition 103.9 95.0 92.0
mitogen-activated protein kinase kinase kinase 10 nd/MLK2(MAP3K10) Hs Inhibitor Inhibition 104.0
VRK serine/threonine kinase 1 nd/VRK1 Hs Inhibitor Inhibition 104.0
leukocyte receptor tyrosine kinase nd/TYK1(LTK) Hs Inhibitor Inhibition 104.1
unc-51 like autophagy activating kinase 2 ULK2/ULK2 Hs Inhibitor Inhibition 104.1 102.0 92.0
ribosomal protein S6 kinase A6 Rsk4/RSK4 Hs Inhibitor Inhibition 104.2 110.0 103.0
component of inhibitor of nuclear factor kappa B kinase complex IKKα/IKKA(CHUK) Hs Inhibitor Inhibition 104.3 97.0 103.0
mitogen-activated protein kinase kinase kinase 8 nd/COT1(MAP3K8) Hs Inhibitor Inhibition 104.6
myosin light chain kinase MLCK/MLCK(MYLK) Hs Inhibitor Inhibition 105.0 96.0 87.0
TYRO3 protein tyrosine kinase Rse/TYRO3(SKY) Hs Inhibitor Inhibition 105.0 95.0 98.0
casein kinase 1 gamma 3 CK1γ3/CK1g3 Hs Inhibitor Inhibition 105.1 82.0 87.0
mitogen-activated protein kinase kinase kinase 5 ASK1/ASK1(MAP3K5) Hs Inhibitor Inhibition 105.4 105.0 96.0
ribosomal protein S6 kinase B2 nd/p70S6Kb(RPS6KB2) Hs Inhibitor Inhibition 105.5
dual specificity tyrosine phosphorylation regulated kinase 1B nd/DYRK1B Hs Inhibitor Inhibition 106.2
CDC like kinase 4 nd/CLK4 Hs Inhibitor Inhibition 106.9
microtubule affinity regulating kinase 4 nd/MARK4 Hs Inhibitor Inhibition 107.4
mitogen-activated protein kinase 8 JNK1α1/JNK1 Hs Inhibitor Inhibition 109.2 120.0 129.0
SRSF protein kinase 1 SRPK1/SRPK1 Hs Inhibitor Inhibition 109.3 101.0 106.0
protein kinase C theta PKCθ/PKCtheta Hs Inhibitor Inhibition 109.5 100.0 111.0
TAO kinase 1 TAO1/TAOK1 Hs Inhibitor Inhibition 110.3 103.0 99.0
casein kinase 1 gamma 1 CK1γ1/CK1g1 Hs Inhibitor Inhibition 110.4 92.0 103.0
mitogen-activated protein kinase kinase kinase 14 nd/NIK(MAP3K14) Hs Inhibitor Inhibition 114.1
mitogen-activated protein kinase kinase 6 MKK6/MKK6 Hs Inhibitor Inhibition 116.7 78.0 83.0
interleukin 1 receptor associated kinase 1 IRAK1/IRAK1 Hs Inhibitor Inhibition 117.1 95.0 95.0
MAPK interacting serine/threonine kinase 1 nd/MNK1 Hs Inhibitor Inhibition 117.5
mitogen-activated protein kinase 14 SAPK2a/P38a(MAPK14) Hs Inhibitor Inhibition 128.4 84.0 66.0
tec protein tyrosine kinase nd/TEC Hs Inhibitor Inhibition 133.5
NUAK family, SNF1-like kinase, 2 nd/SNARK(NUAK2) Hs Inhibitor Inhibition 137.3
tec protein tyrosine kinase Tec (activated)/nd Hs Inhibitor Inhibition 82.0 85.0
LCK proto-oncogene, Src family tyrosine kinase Lck activated Hs Inhibitor Inhibition 83.0 49.0
protein kinase AMP-activated catalytic subunit alpha 1 AMPKα1/nd Hs Inhibitor Inhibition 87.0 78.0
eukaryotic elongation factor 2 kinase eEF-2K/nd Hs Inhibitor Inhibition 88.0 108.0
mechanistic target of rapamycin kinase mTOR-FKBP12/nd Hs Inhibitor Inhibition 88.0 69.0
protein kinase AMP-activated catalytic subunit alpha 2 AMPKα2/nd Hs Inhibitor Inhibition 93.0 72.0
HCK proto-oncogene, Src family tyrosine kinase Hck (activated)/nd Hs Inhibitor Inhibition 97.0 96.0
mechanistic target of rapamycin kinase mTOR/nd Hs Inhibitor Inhibition 98.0 94.0
cyclin dependent kinase 2 CDK2/cyclinE Hs Inhibitor Inhibition 101.0 96.0
Insulin receptor IR (activated)/nd Hs Inhibitor Inhibition 102.0 100.0
VRK serine/threonine kinase 2 VRK2/nd Hs Inhibitor Inhibition 108.0 94.0
Insulin-like growth factor I receptor IGF-1R (activated)/nd Hs Inhibitor Inhibition 109.0 96.0
mitogen-activated protein kinase kinase 7 MKK7β/nd Hs Inhibitor Inhibition 110.0 86.0
salt inducible kinase 1 SIK/nd Hs Inhibitor Inhibition 112.0 82.0

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]

2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]